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Inhalable carrier-free self-assembled leonurine-ursolic acid nanoaggregates ameliorate acute lung injury by suppressing TLR4/MyD88-NET axis

Mater Today Bio. 2026 Aug 18;40:103583. doi: 10.1016/j.mtbio.2026.103583. eCollection 2026 Oct.

ABSTRACT

TLR4 activation and the cascade of neutrophil extracellular trap (NET) formation exacerbate excessive inflammation and organ damage in the pathogenesis of acute lung injury (ALI), yet effective pharmacological interventions remain unavailable. Nanoaggregates derived from natural products offer promising avenue by leveraging synergistic anti-inflammatory effects. In this study, we surprisingly discovered that leonurine and ursolic acid spontaneously self-assemble into nanoparticles (LUNP) through non-covalent interactions, achieving a drug loading capacity of 100%. The LUNP platform exhibits superior biophysical properties, including enhanced mucus penetration, pH-responsive drug release, improved cellular uptake, and prolonged retention within inflamed lung tissue. Mechanistically, LUNP ameliorates ALI by dampening TLR4/MyD88/NF-κB-driven inflammatory activation, thereby remodeling the microenvironment to limit NOX4-PAD4-mediated NET formation. Notably, inhalational LUNP exhibits outstanding biosafety with minimal off-target distribution. Overall, this work introduces a synergistic self-assembled nanoplatform for precise pulmonary intervention in ALI, showcasing its ability to safely and effectively orchestrate the coordinated modulation of multiple pathological pathways. In summary, by inhibiting both TLR4 activation and NET formation, the synergistic LUNP platform offers an efficient, safe, and easily accessible therapeutic strategy for ALI, providing a promising solution for clinical translation.

PMID:42750707 | PMC:PMC13577835 | DOI:10.1016/j.mtbio.2026.103583

Advancing cancer detection and treatment using longitudinal routine clinical data

Liu et al. develop Oncoformer, a multimodal transformer that reads routine laboratory tests and chest X-rays already collected in everyday care. Across more than 3.6 million individuals, it detects cancer, infers tumor stage, and stratifies treatment response and recurrence risk, pointing toward risk-adapted cancer care built on data already in hand.
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  • Kernel-Managed Shared Memory for System-Wide Personalization Ryan Lum · Yongfeng Zhang
    arXiv:2609.10144v1 Announce Type: new Abstract: AI systems become more useful when they can adapt to the people using them, but in multi-agent systems, useful context learned by one agent often remains unavailable to others. We present kernel-managed shared memory, a system-level abstraction in which specialized agents write structured, tagged memories while the agent-system kernel, not individual agents, governs retrieval, privacy enforcement, and prompt injection. We implement and evaluate th
     

Kernel-Managed Shared Memory for System-Wide Personalization

arXiv:2609.10144v1 Announce Type: new Abstract: AI systems become more useful when they can adapt to the people using them, but in multi-agent systems, useful context learned by one agent often remains unavailable to others. We present kernel-managed shared memory, a system-level abstraction in which specialized agents write structured, tagged memories while the agent-system kernel, not individual agents, governs retrieval, privacy enforcement, and prompt injection. We implement and evaluate this design on AIOS and compare it against three alternatives across three assistant models (GPT-4o, Llama-3.1:8B, Qwen-2.5:7B) and 1,800 total trials. Against an unmanaged external memory backend (Mem0) using identical underlying storage, kernel-managed retrieval and injection improve personalization scores by 2.4-4.0 points on a 5-point scale (e.g., 1.05 to 4.69 profile usage on GPT-4o), with every comparison significant at p

VEN-VL: A Visual Ensemble MoE Framework for Effective and Efficient Multi-Modal Understanding

arXiv:2605.25952v1 Announce Type: cross Abstract: Despite the remarkable progress achieved by recent efficient methods in accelerating multimodal understanding, they still suffer from noticeable performance degradation. Their emphasis on the high compression ratio of a single visual clue and reliance on the heuristic pruning strategy with coarse attention alignment incurs a bottleneck on the information capacity and density of visual tokens. Addressing this limitation, we propose VEN-VL, a visual ensemble MoE framework for effective and efficient perception following the enrich then compact principle. Specifically, we first enrich the information capacity by unifying the visual representations of different perspectives, and then progressively compact it with adaptive routers in specialized visual experts to enhance the information density. Furthermore, we incorporate the reconstruction ability of vanilla structure via explicit visual supervision, facilitating crucial information preservation. Experimental results demonstrate our superiority in complex visual tasks with few information-condensed tokens, which effectively bridges the gap between performance and efficiency.

Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain

A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.

Generative AI in Action: Field Experimental Evidence from Alibaba's Customer Service Operations

arXiv:2603.29888v1 Announce Type: cross Abstract: In collaboration with Alibaba, this study leverages a large-scale field experiment to assess the impact of a generative AI assistant on worker performance in e-commerce after-sales service. Human agents providing digital chat support were randomly assigned with access to a gen AI assistant that offered two core functions: diagnosis of customer issues and solution proposals, presented as text messages. Agents retained discretion to adopt, modify, or disregard AI-generated messages. To evaluate gen AI's impact, we estimate both the intention-to-treat (ITT) effect of gen AI access and the local average treatment effect (LATE) of gen AI usage. Results show that gen AI significantly improved service speed, measured by issue identification time and chat duration. Gen AI also improved subjective service quality reflected in customer ratings and dissatisfaction rates, but it had no significant effect on objective service quality indicated by customer retrial rates. The performance improvements stemmed not only from automation but also from changes in the dynamics of agent-customer interactions: agent communication became more informative and efficient, while customers experienced reduced communication burdens. Low performers achieved the greatest improvements in both service speed and quality, narrowing the performance gap. In contrast, top-performing agents showed little improvement in service speed but experienced declines in both subjective and objective service quality. Evidence suggests that this decline results from increased multitasking tendency, proxied by longer shift-away times across concurrent chats, which slowed customer responses and raised abandonment and retrial rates. These findings suggest that gen AI reshapes work, demanding tailored deployment strategies.

Hierarchical Long Video Understanding with Audiovisual Entity Cohesion and Agentic Search

arXiv:2601.13719v2 Announce Type: replace-cross Abstract: Long video understanding presents significant challenges for vision-language models due to extremely long context windows. Existing solutions relying on naive chunking strategies with retrieval-augmented generation, typically suffer from information fragmentation and a loss of global coherence. We present HAVEN, a unified framework for long-video understanding that enables coherent and comprehensive reasoning by integrating audiovisual entity cohesion and hierarchical video indexing with agentic search. First, we preserve semantic consistency by integrating entity-level representations across visual and auditory streams, while organizing content into a structured hierarchy spanning global summary, scene, segment, and entity levels. Then we employ an agentic search mechanism to enable dynamic retrieval and reasoning across these layers, facilitating coherent narrative reconstruction and fine-grained entity tracking. Extensive experiments demonstrate that our method achieves good temporal coherence, entity consistency, and retrieval efficiency, establishing a new state-of-the-art with an overall accuracy of 84.1% on LVBench. Notably, it achieves outstanding performance in the challenging reasoning category, reaching 80.1%. These results highlight the effectiveness of structured, multimodal reasoning for comprehensive and context-consistent understanding of long-form videos.
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