npj Digital Medicine, Published online: 12 September 2026; doi:10.1038/s41746-026-03203-2

Deep learning combined habitat radiomics analysis of central lymph node metastasis in papillary thyroid carcinoma

Oncogenesis, Published online: 08 May 2026; doi:10.1038/s41389-026-00621-5

Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU

arXiv:2604.01690v1 Announce Type: new Abstract: The rapid proliferation of Artificial Intelligence-Generated Content (AIGC) is fundamentally restructuring online content ecologies, necessitating a rigorous examination of its behavioral and distributional implications. Leveraging a comprehensive longitudinal dataset comprising tens of millions of users from a leading Chinese video-sharing platform, this study elucidated the distinct creation and consumption behaviors characterizing AIGC versus Human-Generated Content (HGC). We identified a prevalent scale-over-preference dynamic, wherein AIGC creators achieve aggregate engagement comparable to HGC creators through high-volume production, despite a marked consumer preference for HGC. Deeper analysis uncovered the ability of the algorithmic content distribution mechanism in moderating these competing interests regarding AIGC. These findings advocated for the implementation of AIGC-sensitive distribution algorithms and precise governance frameworks to ensure the long-term health of the online content platforms.

arXiv:2604.02288v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has become a standard paradigm for post-training large language models. While Group Relative Policy Optimization (GRPO) is widely adopted, its coarse credit assignment uniformly penalizes failed rollouts, lacking the token-level focus needed to efficiently address specific deviations. Self-Distillation Policy Optimization (SDPO) addresses this by providing denser, more targeted logit-level supervision that facilitates rapid early improvement, yet it frequently collapses during prolonged training. We trace this late-stage instability to two intrinsic flaws: self-distillation on already-correct samples introduces optimization ambiguity, and the self-teacher's signal reliability progressively degrades. To resolve these issues, we propose Sample-Routed Policy Optimization (SRPO), a unified on-policy framework that routes correct samples to GRPO's reward-aligned reinforcement and failed samples to SDPO's targeted logit-level correction. SRPO further incorporates an entropy-aware dynamic weighting mechanism to suppress high-entropy, unreliable distillation targets while emphasizing confident ones. Evaluated across five benchmarks and two model scales, SRPO achieves both the rapid early improvement of SDPO and the long-horizon stability of GRPO. It consistently surpasses the peak performance of both baselines, raising the five-benchmark average on Qwen3-8B by 3.4% over GRPO and 6.3% over SDPO, while simultaneously yielding moderate response lengths and lowering per-step compute cost by up to 17.2%.

arXiv:2603.23406v2 Announce Type: replace Abstract: While large language models simulate social behaviors, their capacity for stable stance formation and identity negotiation during complex interventions remains unclear. To overcome the limitations of static evaluations, this paper proposes a novel mixed-methods framework combining computational virtual ethnography with quantitative socio-cognitive profiling. By embedding human researchers into generative multiagent communities, controlled discursive interventions are conducted to trace the evolution of collective cognition. To rigorously measure how agents internalize and react to these specific interventions, this paper formalizes three new metrics: Innate Value Bias (IVB), Persuasion Sensitivity, and Trust-Action Decoupling (TAD). Across multiple representative models, agents exhibit endogenous stances that override preset identities, consistently demonstrating an innate progressive bias (IVB > 0). When aligned with these stances, rational persuasion successfully shifts 90% of neutral agents while maintaining high trust. In contrast, conflicting emotional provocations induce a paradoxical 40.0% TAD rate in advanced models, which hypocritically alter stances despite reporting low trust. Smaller models contrastingly maintain a 0% TAD rate, strictly requiring trust for behavioral shifts. Furthermore, guided by shared stances, agents use language interactions to actively dismantle assigned power hierarchies and reconstruct self organized community boundaries. These findings expose the fragility of static prompt engineering, providing a methodological and quantitative foundation for dynamic alignment in human-agent hybrid societies. The official code is available at: https://github.com/armihia/CMASE-Endogenous-Stances

arXiv:2603.23406v1 Announce Type: new Abstract: While large language models simulate social behaviors, their capacity for stable stance formation and identity negotiation during complex interventions remains unclear. To overcome the limitations of static evaluations, this paper proposes a novel mixed-methods framework combining computational virtual ethnography with quantitative socio-cognitive profiling. By embedding human researchers into generative multiagent communities, controlled discursive interventions are conducted to trace the evolution of collective cognition. To rigorously measure how agents internalize and react to these specific interventions, this paper formalizes three new metrics: Innate Value Bias (IVB), Persuasion Sensitivity, and Trust-Action Decoupling (TAD). Across multiple representative models, agents exhibit endogenous stances that override preset identities, consistently demonstrating an innate progressive bias (IVB > 0). When aligned with these stances, rational persuasion successfully shifts 90% of neutral agents while maintaining high trust. In contrast, conflicting emotional provocations induce a paradoxical 40.0% TAD rate in advanced models, which hypocritically alter stances despite reporting low trust. Smaller models contrastingly maintain a 0% TAD rate, strictly requiring trust for behavioral shifts. Furthermore, guided by shared stances, agents use language interactions to actively dismantle assigned power hierarchies and reconstruct self organized community boundaries. These findings expose the fragility of static prompt engineering, providing a methodological and quantitative foundation for dynamic alignment in human-agent hybrid societies. The official code is available at: https://github.com/armihia/CMASE-Endogenous-Stances

arXiv:2603.22911v1 Announce Type: cross Abstract: Due to the great saving of computation and memory overhead, token compression has become a research hot-spot for MLLMs and achieved remarkable progress in image-language tasks. However, for the video, existing methods still fall short of high-ratio token compression. We attribute this shortcoming to the insufficient modeling of temporal and continual video content, and propose a novel and training-free token pruning method for video MLLMs, termed ForestPrune, which achieves effective and high-ratio pruning via Spatial-temporal Forest Modeling. In practice, ForestPrune construct token forests across video frames based on the semantic, spatial and temporal constraints, making an overall comprehension of videos. Afterwards, ForestPrune evaluates the importance of token trees and nodes based on tree depth and node roles, thereby obtaining a globally optimal pruning decision. To validate ForestPrune, we apply it to two representative video MLLMs, namely LLaVA-Video and LLaVA-OneVision, and conduct extensive experiments on a bunch of video benchmarks. The experimental results not only show the great effectiveness for video MLLMs, e.g., retaining 95.8% average accuracy while reducing 90% tokens for LLaVA-OneVision, but also show its superior performance and efficiency than the compared token compression methods, e.g., +10.1% accuracy on MLVU and -81.4% pruning time than FrameFusion on LLaVA-Video.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y

Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.

arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill systems. This survey studies these developments under a single notion of \emph{adaptation}: improving an agent, its tools, or their interaction after pretraining. We organize the field with a four-paradigm framework spanning agent adaptation and tool adaptation. On the agent side, A1 (tool-execution-signaled) and A2 (agent-output-signaled) improve the agent itself through supervised fine-tuning, preference optimization, and reinforcement learning with verifiable rewards. On the tool side, T1 (agent-agnostic) provides reusable pre-trained modules any agent can call, while T2 (agent-supervised) uses the agent's outputs to train memory systems, skill libraries, or lightweight subagents. Using this framework, we review post-training methods, adaptive memory architectures, and agent skills; compare their trade-offs in cost, flexibility, and generalization; and summarize evaluation practices across deep research, software development, computer use, and drug discovery. We conclude by outlining open problems in agent-tool co-adaptation, continual learning, safety, and efficient deployment.

arXiv:2602.18880v1 Announce Type: cross Abstract: Advances in image tampering techniques, particularly generative models, pose significant challenges to media verification, digital forensics, and public trust. Existing image forgery detection and localization (IFDL) methods suffer from two key limitations: over-reliance on semantic content while neglecting textural cues, and limited interpretability of subtle low-level tampering traces. To address these issues, we propose FOCA, a multimodal large language model-based framework that integrates discriminative features from both the RGB spatial and frequency domains via a cross-attention fusion module. This design enables accurate forgery detection and localization while providing explicit, human-interpretable cross-domain explanations. We further introduce FSE-Set, a large-scale dataset with diverse authentic and tampered images, pixel-level masks, and dual-domain annotations. Extensive experiments show that FOCA outperforms state-of-the-art methods in detection performance and interpretability across both spatial and frequency domains.

arXiv:2602.13575v1 Announce Type: cross Abstract: Current alignment methods for Large Language Models (LLMs) rely on compressing vast amounts of human preference data into static, absolute reward functions, leading to data scarcity, noise sensitivity, and training instability. We introduce Elo-Evolve, a co-evolutionary framework that redefines alignment as dynamic multi-agent competition within an adaptive opponent pool. Our approach makes two key innovations: (1) eliminating Bradley-Terry model dependencies by learning directly from binary win/loss outcomes in pairwise competitions, and (2) implementing Elo-orchestrated opponent selection that provides automatic curriculum learning through temperature-controlled sampling. We ground our approach in PAC learning theory, demonstrating that pairwise comparison achieves superior sample complexity and empirically validate a 4.5x noise reduction compared to absolute scoring approaches. Experimentally, we train a Qwen2.5-7B model using our framework with opponents including Qwen2.5-14B, Qwen2.5-32B, and Qwen3-8B models. Results demonstrate a clear performance hierarchy: point-based methods