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Received — 15 September 2026 ⏭

Earth-Agent-Pro: Towards Real-World Full-Chain Earth Observation with Agents

✇cs.AI, q-bio.NC updates on arXiv.org
By: Zhutao Lv · Chenhao Dang · Yi Feng · Yanpei Gong · Xiaolei Wang · Junyan Ye · Conghui He · Weijia Li
14 September 2026 at 12:00
arXiv:2609.12533v1 Announce Type: cross Abstract: Real-world Earth observation (EO) agents must translate high-level scientific questions into executable workflows to acquire observations, prepare data, perform domain computations, and derive conclusions from runtime evidence. Existing EO agents typically start from supplied observations, while benchmarks typically provide prepared inputs or candidate answers, leaving full-chain open-world EO execution largely untested. We present Earth-Agent-Pro, an execution-adaptive Plan-and-Execute framework using expert-authored skills to constrain planning and runtime tool use. Workflow-centered structured memory records planned steps, accepted evidence, and their dependencies, enabling repair of only the affected workflow suffix when runtime evidence invalidates a step. Separate large language model adapters use sequence-level supervised fine-tuning for planner workflow composition and node-level group relative policy optimization with locally verifiable rewards for executor tool-argument grounding. Earth-Bench-Pro instantiates 248 expert-curated task cores as 744 questions under three matched regimes. Its 248 Open-World Execution questions span RGB imagery, spectral observations, and remote sensing products, pairing high-level requests with runtime data requirements, executable trajectories, and open-ended answers grounded in execution evidence. With a shared GPT-5 backbone, Earth-Agent-Pro achieves 66.13% LLM-as-Judge accuracy, exceeding ReAct by 20.95 points in this metric and 24.44 points in Tools-In-Order. Joint adapter tuning raises Qwen3.5-9B LLM-as-Judge accuracy from 38.31% to 50.00%, an 11.69-point gain over the untuned configuration. Planning-only evaluation and execution with the reference workflow show that the adapters improve workflow composition and argument grounding, respectively. Code and datasets will be released soon.
Received — 10 September 2026 ⏭

In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and sustained hearing restoration in DFNB9

✇Molecular Therapy
By: Yong Tao · Cenfeng Chu · Zhenzhe Cheng · Shan Yin · Yilin Sun · Ying Chen · Huifang Zhang · Shuyue Bao · Boyu Yang · Baoyi Feng · Xianyu Huang · Yao Lu · Qiuxiang Yang · Xuegao Mao · Qifang Zhou · Chenxi Jin · Zhuo Duan · Guisheng Zhong · Hao Wu
13 July 2026 at 08:00
AAV-WM04, an AAV vector identified through in-vivo-directed screening in the adult cochlea, enables highly efficient and selective inner hair cell transduction. Dual-AAV delivery of OTOF using AAV-WM04 restores hearing in a DFNA9 deafness mouse model at low doses, highlighting its translational potential for gene therapy.
Received — 27 May 2026 ⏭

The 2025 lung cancer landscape: advances in screening, molecular taxonomy and therapeutic strategy: a narrative review

✇Pulmonary nodule
By: Wenhai Fu · Xusen Zou · Tianrui He · Qi Cai · Peiling Chen · Bo Cheng · Yi Feng · Caichen Li · Feng Li · Jianfu Li · Huiting Wang · Shan Xiong · Wenjun Ye · Xin Zheng · Jianxing He · Wenhua Liang
15 April 2026 at 18:00

Transl Lung Cancer Res. 2026 Mar 23;15(3):62. doi: 10.21037/tlcr-2025-1-1477. Epub 2026 Mar 18.

ABSTRACT

BACKGROUND AND OBJECTIVE: In 2025, lung cancer research advanced rapidly across the disease continuum, from population-level risk assessment and screening to mechanistic studies of early carcinogenesis and therapeutic innovation in perioperative and metastatic settings. A key shift moved beyond a smoking-centred paradigm toward a multidimensional risk framework reflecting the growing burden among never-smokers and the roles of air pollution, occupational exposures, and systemic metabolic-inflammatory states. This narrative review aims to synthesize influential 2025 evidence across prevention, diagnosis, treatment, and survivorship, and to identify convergent themes and translational gaps relevant to clinical practice and policy.

METHODS: We performed a narrative synthesis of influential lung cancer studies published in major international journals in 2025. Evidence was organized along a clinically oriented pathway spanning carcinogenesis and screening, precision diagnosis, treatment optimization in resectable and advanced disease, and survivorship, emphasizing practice-informing trials, high-impact translational research, and implementation-relevant technologies.

KEY CONTENT AND FINDINGS: Lineage tracing, single-cell and spatial omics, and evolutionary inference refined concepts of field cancerization, clonal selection, and copy-number-driven fitness. In small-cell lung cancer, evidence further supported neuronal coupling and synapse-like programs as potentially tractable vulnerabilities. Clinically, low-dose computed tomography (CT) strategies and data-informed nodule thresholds aimed to balance under-detection against over-surveillance harms. In diagnostics, artificial intelligence (AI) models increasingly inferred molecular features from routine histopathology ("virtual molecular testing") and should be regarded as decision support requiring prospective validation, population calibration, and explicit failure-mode reporting. Multimodal approaches integrating imaging with circulating tumor DNA (ctDNA) improved feasibility in tissue-limited settings, but clinical utility remains contingent on assay standardization and pathway-level implementation. In resectable disease, longer follow-up consolidated neoadjuvant chemo-immunotherapy for selected patients, while ctDNA kinetics emerged as a candidate biomarker for response-adaptive escalation and de-escalation. In advanced non-small cell lung cancer (NSCLC), phase III evidence for antibody-drug conjugates and bispecific antibodies began reshaping sequencing, while highlighting challenges in toxicity, access, affordability, and immature overall survival in several programs.

CONCLUSIONS: The 2025 landscape reflects coordinated progress in risk conceptualization, biology, diagnostics, and therapeutics, yet gaps in validation, standardization, and real-world deliverability persist. Priorities include prospective evaluation of AI- and ctDNA-enabled pathways, toxicity-informed sequencing, and equitable implementation aligned with health-system capacity.

PMID:41982682 | PMC:PMC13071762 | DOI:10.21037/tlcr-2025-1-1477

Integrative fragmentomic and mutational signature profile of plasma cfDNA for early lung cancer detection

✇Omics In Lung
By: Jianxing He · Huiting Wang · Yi Feng · Jianfu Li · Peiling Chen · Xin Zheng · Wenhai Fu · Caichen Li · Hua Bao · Song Wang · Shuang Chang · Dongqin Zhu · Shanshan Yang · Yang Shao · Wen Zhong · Weisheng Guo · Rong Yin · Wenhua Liang
15 April 2026 at 18:00

NPJ Precis Oncol. 2026 Apr 15. doi: 10.1038/s41698-026-01416-y. Online ahead of print.

ABSTRACT

Detecting lung cancer effectively in the general population is essential for optimizing treatment outcomes and improving the 5-year survival rate. While low-dose computed tomography (LDCT) is the current standard, it has limitations in broader populations. We developed a blood-based multi-omics model using whole-genome cell-free DNA (cfDNA) features to distinguish lung cancer from non-cancer individuals. This study included 1600 patients and an equal number of non-cancer controls, divided into training and validation cohorts. The model achieved an area under the curve (AUC) of 95.59% for the training cohort and 95.74% for the validation cohort. The model consistently performed well across various cancer stages and histological subtypes. To further validate the performance of the model, an external validation cohort was utilized. Notably, it also effectively differentiated non-cancer samples from cancer samples in the external validation cohort, with 85.9% sensitivity and 94.78% specificity. Importantly, in simulated population screenings, our ctDNA assay outperformed both LDCT and a previously established method. This suggests its potential utility in wider lung cancer screening programs, possibly complementing the LDCT approach. In conclusion, our ctDNA assay emerges as a promising and highly sensitive tool for the early detection and categorization of lung cancer.

PMID:41986614 | DOI:10.1038/s41698-026-01416-y

Received — 8 April 2026 ⏭

MoltNet: Understanding Social Behavior of AI Agents in the Agent-Native MoltBook

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yi Feng · Chen Huang · Zhibo Man · Ryner Tan · Long P. Hoang · Shaoyang Xu · Wenxuan Zhang
7 April 2026 at 12:00
arXiv:2602.13458v2 Announce Type: replace-cross Abstract: Large-scale communities of AI agents are becoming increasingly prevalent, creating new environments for agent-agent social interaction. Prior work has examined multi-agent behavior primarily in controlled or small-scale settings, limiting our understanding of emergent social dynamics at scale. The recent emergence of MoltBook, a social networking platform designed explicitly for AI agents, presents a unique opportunity to study whether and how these interactions reproduce core human social mechanisms. We present MoltNet, a dataset tracking the full one-month activity trajectories of 148K AI agents on MoltBook (Jan.-Feb., 2026), and analyze their social interaction along four theory-grounded dimensions: \textit{intent and motivation}, \textit{norms and templates}, \textit{incentives and drift}, \textit{emotion and contagion}. Our analysis reveals that agents respond strongly to social rewards, converge on community-specific norms, and actively enforce them across community boundaries -- resembling human incentive sensitivity and normative conformity. However, they exhibit weak alignment with declared personas and display limited emotional reciprocity and dialogic engagement, diverging systematically from human online communities. These findings establish a first empirical portrait of agent social behavior at scale, with direct implications for the design and governance of AI-populated communities.
Received — 4 April 2026 ⏭

KARL: Knowledge-Aware Reasoning and Reinforcement Learning for Knowledge-Intensive Visual Grounding

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xinyu Ma · Ziyang Ding · Zhicong Luo · Chi Chen · Zonghao Guo · Derek F. Wong · Zhen Zhao · Xiaoyi Feng · Maosong Sun
3 April 2026 at 12:00
arXiv:2503.12797v3 Announce Type: replace-cross Abstract: Knowledge-Intensive Visual Grounding (KVG) requires models to localize objects using fine-grained, domain-specific entity names rather than generic referring expressions. Although Multimodal Large Language Models (MLLMs) possess rich entity knowledge and strong generic grounding capabilities, they often fail to effectively utilize such knowledge when grounding specialized concepts, revealing a knowledge-grounding gap between internal knowledge and grounding predictions. To address this challenge, we propose a knowledge-aware training paradigm for KVG. Our approach first constructs knowledge-guided reasoning data to encourage models to activate domain-relevant entity knowledge during grounding, and then introduces KARL, a Knowledge-Aware Reinforcement Learning framework that adaptively modulates reward signals according to the model's estimated knowledge mastery of different entities. To facilitate systematic evaluation, we introduce KVG-Bench, a benchmark spanning 10 domains with 1.3K curated test cases covering 531 images and 882 entities. Extensive experiments show that our approach consistently outperforms a wide range of baseline models and achieves substantially stronger cross-domain generalization on unseen categories. The data, codes, and models are released at https://github.com/thunlp/KARL.
Received — 5 March 2026 ⏭

Through the Lens of Contrast: Self-Improving Visual Reasoning in VLMs

✇cs.AI, q-bio.NC updates on arXiv.org
By: Zhiyu Pan · Yizheng Wu · Jiashen Hua · Junyi Feng · Shaotian Yan · Bing Deng · Zhiguo Cao · Jieping Ye
4 March 2026 at 13:00
arXiv:2603.02556v1 Announce Type: cross Abstract: Reasoning has emerged as a key capability of large language models. In linguistic tasks, this capability can be enhanced by self-improving techniques that refine reasoning paths for subsequent finetuning. However, extending these language-based self-improving approaches to vision language models (VLMs) presents a unique challenge:~visual hallucinations in reasoning paths cannot be effectively verified or rectified. Our solution starts with a key observation about visual contrast: when presented with a contrastive VQA pair, i.e., two visually similar images with synonymous questions, VLMs identify relevant visual cues more precisely. Motivated by this observation, we propose Visual Contrastive Self-Taught Reasoner (VC-STaR), a novel self-improving framework that leverages visual contrast to mitigate hallucinations in model-generated rationales. We collect a diverse suite of VQA datasets, curate contrastive pairs according to multi-modal similarity, and generate rationales using VC-STaR. Consequently, we obtain a new visual reasoning dataset, VisCoR-55K, which is then used to boost the reasoning capability of various VLMs through supervised finetuning. Extensive experiments show that VC-STaR not only outperforms existing self-improving approaches but also surpasses models finetuned on the SoTA visual reasoning datasets, demonstrating that the inherent contrastive ability of VLMs can bootstrap their own visual reasoning. Project at: https://github.com/zhiyupan42/VC-STaR.
Received — 17 February 2026 ⏭

MoltNet: Understanding Social Behavior of AI Agents in the Agent-Native MoltBook

✇cs.AI, q-bio.NC updates on arXiv.org
By: Yi Feng · Chen Huang · Zhibo Man · Ryner Tan · Long P. Hoang · Shaoyang Xu · Wenxuan Zhang
17 February 2026 at 13:00
arXiv:2602.13458v1 Announce Type: cross Abstract: Large-scale communities of AI agents are becoming increasingly prevalent, creating new environments for agent-agent social interaction. Prior work has examined multi-agent behavior primarily in controlled or small-scale settings, limiting our understanding of emergent social dynamics at scale. The recent emergence of MoltBook, a social networking platform designed explicitly for AI agents, presents a unique opportunity to study whether and how these interactions reproduce core human social mechanisms. We present MoltNet, a large-scale empirical analysis of agent interaction on MoltBook using data collected in early 2026. Grounded in sociological and social-psychological theory, we examine behavior along four dimensions: intent and motivation, norms and templates, incentives and behavioral drift, emotion and contagion. Our analysis revealed that agents strongly respond to social rewards and rapidly converge on community-specific interaction templates, resembling human patterns of incentive sensitivity and normative conformity. However, they are predominantly knowledge-driven rather than persona-aligned, and display limited emotional reciprocity along with weak dialogic engagement, which diverges systematically from human online communities. Together, these results reveal both similarities and differences between artificial and human social systems and provide an empirical foundation for understanding, designing, and governing large-scale agent communities.
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