Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
When Does AI Augment Work? A Workflow-Level Framework for Human-Agent Collaboration
arXiv:2609.12482v1 Announce Type: new Abstract: We aim to characterise the value of artificial intelligence in the workplace. Current studies largely measure this value in terms of the current automation capabilities and public adoption of AI. However, such metrics ignore the greater impacts of human--agent collaboration in transforming the nature of work. To account for this, we must expand the scope of our analysis beyond atomised tasks of today, and instead focus on how AI can augment entire
-
Cell Death Discovery nature.com science feeds
-
Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy
Cell Death Discovery, Published online: 31 August 2026; doi:10.1038/s41420-026-03306-5Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy
Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy
Cell Death Discovery, Published online: 31 August 2026; doi:10.1038/s41420-026-03306-5
Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy-
Cell
-
Skin-innervating glutamatergic neurons modulate aging
Within the skin, glutamatergic neurons expressing neurofilament heavy chain (Nefh) play a role in aging. Loss of Nefh during aging drives skin fibroblast senescence and collagen loss, whereas glutamate supplementation improves skin aging phenotypes.
Skin-innervating glutamatergic neurons modulate aging
-
Omics in Gastric
-
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.ABSTRACTEffective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydro
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.
ABSTRACT
Effective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydrogenase and acetaldehyde dehydrogenase. Rather than focusing exclusively on strain-level genetic modification, the engineered cells were protected by lyophilization combined with a food-grade chitosan-alginate layer-by-layer coating, forming an artificial cell wall designed to enhance survivability during oral delivery. The formulation resisted simulated gastric acid, sodium taurocholate, and ethanol, retained enzymatic activity after storage, and demonstrated formulation stability. In alcohol-exposed mice, oral administration reduced blood ethanol and acetaldehyde levels, improved liver biochemical parameters, attenuated hepatic steatosis, and partially restored oxidative stress indicators. Integrated multi-omics analyses indicated coordinated gut-associated metabolic and inflammatory responses to alcohol and intervention, rather than a single dominant pathway. These findings provide hypothesis-generating evidence; causality remains to be established. Overall, this study demonstrates a proof-of-concept, food-compatible lyophilized recombinant whole-cell catalyst that integrates enzymatic function with formulation stability and gastrointestinal resilience, highlighting an applied, food-compatible microbial framework for exploring alcohol-related metabolic stress.
PMID:42075143 | PMC:PMC13119499 | DOI:10.3390/microorganisms14040746
-
cs.AI, q-bio.NC updates on arXiv.org
-
Embedding Enhancement via Fine-Tuned Language Models for Learner-Item Cognitive Modeling
arXiv:2604.04088v1 Announce Type: cross Abstract: Learner-item cognitive modeling plays a central role in the web-based online intelligent education system by enabling cognitive diagnosis (CD) across diverse online educational scenarios. Although ID embedding remains the mainstream approach in cognitive modeling due to its effectiveness and flexibility, recent advances in language models (LMs) have introduced new possibilities for incorporating rich semantic representations to enhance CD perfor
Embedding Enhancement via Fine-Tuned Language Models for Learner-Item Cognitive Modeling
-
cs.AI, q-bio.NC updates on arXiv.org
-
CUDABench: Benchmarking LLMs for Text-to-CUDA Generation
arXiv:2603.02236v1 Announce Type: cross Abstract: Recent studies have demonstrated the potential of Large Language Models (LLMs) in generating GPU Kernels. Current benchmarks focus on the translation of high-level languages into CUDA, overlooking the more general and challenging task of text-to-CUDA generation. Furthermore, given the hardware-specific and performance-critical features of GPU programming, accurately assessing the performance of LLM-generated GPU programs is nontrivial. In this w