Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4

Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.

arXiv:2609.09589v1 Announce Type: new Abstract: Deep neural networks exhibit regular macroscopic behavior despite highly nonlinear dynamics in vast parameter spaces. We develop a statistical-mechanical description of learning directly in function space, treating parameter configurations as microscopic realizations and functions with their dynamical operators as macroscopic variables. For mean-squared loss, the exact error dynamics are governed by the learning operator \(M=JJ^\ast\). Combining the dynamical Boltzmann weight of the conditional stochastic dynamics with the parameter-space density of states, whose local curvature defines a statistical operator \(B\), and integrating over local fluctuations yields $$ \Phi_{\mathrm{fluc}}(M;B)=\frac{\sigma_\xi^2}{2}\log\det(M^{-1}+B)+\mathrm{const}. $$ At fixed spectrum, this term is rotationally stationary when \([M,B]=0\), is minimized by pairing large eigenvalues of \(M\) with small eigenvalues of \(B\), and generates a local restoring contribution against rotational mismatch. For ReLU-type function spaces under mild stable statistical conditions, \(B=\sigma_\xi^2L^\ast\mathcal K L\), where \(L\) measures coarse-grained second-order structure. Thus the low-\(B\) sector corresponds, up to bounded anisotropy of \(\mathcal K\), to low structural curvature, implying a preference for faster relaxation along smooth, data-adaptive directions. These results identify function space as a natural macroscopic level for studying stable collective organization in learning.

arXiv:2605.24844v1 Announce Type: new Abstract: While general-purpose Large Language Models (LLMs) applied to Geology often hallucinate when reasoning about subsurface structures and deep-time evolution, current AI in Earth sciences predominantly targets surface remote sensing and GIS. To bridge this gap, we introduce Geo-Expert, a family of parameter-efficient geological LLMs fine-tuned on a custom-curated, high-quality instruction dataset processed using our custom instruction synthesis pipeline. We investigate the impact of model scaling and architecture by fine-tuning three base models: Qwen3-8B, Qwen3-32B, and Gemma-3-27B, with Low-Rank Adaptation (LoRA) method. Our extensive evaluation on a novel domain-specific benchmark, Geo-Eval, reveals that a domain-aligned 8B model can outperform open-weight 70B generalists and proprietary GPT-4o on specialized geological reasoning, while a 32B variant approaches frontier reasoning models. The optimized 8B model further offers a competitive cost-performance ratio for deployment. This work provides a reproducible recipe for democratizing scientific LLMs and establishes a baseline for geological artificial intelligence.