Subretinal fibrosis causes irreversible vision loss in neovascular age-related macular degeneration (AMD). This study shows that proline metabolism, particularly P4HA1-mediated proline hydroxylation, is activated in JR5558 mice and human AMD tissues. Diethyl pythiDC reduced collagen turnover and fibrovascular lesion expansion, with potential added benefit when combined with aflibercept.

arXiv:2603.26571v2 Announce Type: replace-cross Abstract: Recent advances in generative modeling have enabled perceptual video compression at ultra-low bitrates, yet existing methods predominantly treat the generative model as a refinement or reconstruction module attached to a separately designed codec backbone. We propose \emph{Generative Video Codebook Codec} (GVCC), a zero-shot framework that turns a pretrained video generative model into the codec itself: the transmitted bitstream directly specifies the generative decoding trajectory, with no retraining required. To enable this, we convert the deterministic rectified-flow ODE of modern video foundation models into an equivalent SDE at inference time, unlocking per-step stochastic injection points for codebook-driven compression. Building on this unified backbone, we instantiate three complementary conditioning strategies -- \emph{Image-to-Video} (I2V) with autoregressive GOP chaining, tail latent residual correction, and adaptive atom allocation, \emph{Text-to-Video} (T2V) operating at near-zero side information as a pure generative prior, and \emph{First-Last-Frame-to-Video} (FLF2V) with boundary-sharing GOP chaining for dual-anchor temporal control. Together, these variants span a principled trade-off space between spatial fidelity, temporal coherence, and compression efficiency. Experiments on standard benchmarks show that GVCC achieves high-quality reconstruction below 0.002\,bpp while supporting flexible bitrate control through a single hyperparameter.