Normal view
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Molecular Therapy
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Targeting N7-methylguanosine tRNA modification blocks hepatocellular carcinoma metastasis after insufficient radiofrequency ablation
(Molecular Therapy 31, 1596–1614; June 2023)
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cs.AI, q-bio.NC updates on arXiv.org
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Phase-Aware Spatial-Frequency Fusion for Few-Shot Fine-Grained Image Classification
arXiv:2609.03829v2 Announce Type: replace-cross Abstract: Few-shot fine-grained image classification (FSFGIC) aims to classify similar images with limited labeled examples. This work highlights the critical yet underutilized role of phase information in capturing structural relationships within an image. This study introduces a novel plug-and-play amplitude-phase integration (API) module that effectively combines local and global frequency amplitude and phase information for obtaining more comp
Phase-Aware Spatial-Frequency Fusion for Few-Shot Fine-Grained Image Classification
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cs.AI, q-bio.NC updates on arXiv.org
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OSDTW: Optimal Shared Depth and Task Weighting for Long-Tailed Recognition
arXiv:2605.24969v1 Announce Type: cross Abstract: Long-tailed recognition suffers from a persistent head--tail trade-off: improving tail performance often degrades head accuracy and can increase training instability. Despite strong empirical results from re-weighting, decoupled training, and multi-expert methods, key design choices about representation sharing between head and tail classes and supervision weighting across class groups remain largely heuristic. In this work, we propose OSDTW, a
OSDTW: Optimal Shared Depth and Task Weighting for Long-Tailed Recognition
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Omics in Gastric
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An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.ABSTRACTEffective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydro
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.
ABSTRACT
Effective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydrogenase and acetaldehyde dehydrogenase. Rather than focusing exclusively on strain-level genetic modification, the engineered cells were protected by lyophilization combined with a food-grade chitosan-alginate layer-by-layer coating, forming an artificial cell wall designed to enhance survivability during oral delivery. The formulation resisted simulated gastric acid, sodium taurocholate, and ethanol, retained enzymatic activity after storage, and demonstrated formulation stability. In alcohol-exposed mice, oral administration reduced blood ethanol and acetaldehyde levels, improved liver biochemical parameters, attenuated hepatic steatosis, and partially restored oxidative stress indicators. Integrated multi-omics analyses indicated coordinated gut-associated metabolic and inflammatory responses to alcohol and intervention, rather than a single dominant pathway. These findings provide hypothesis-generating evidence; causality remains to be established. Overall, this study demonstrates a proof-of-concept, food-compatible lyophilized recombinant whole-cell catalyst that integrates enzymatic function with formulation stability and gastrointestinal resilience, highlighting an applied, food-compatible microbial framework for exploring alcohol-related metabolic stress.
PMID:42075143 | PMC:PMC13119499 | DOI:10.3390/microorganisms14040746
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Cell
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An activated wheat CCG10-NLR immune receptor forms an octameric resistosome
An activated CCG10-NLR WAI3 plant immune receptor forms an octameric resistosome, which induces calcium influx and immune responses through a unique channel architecture.
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome
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cs.AI, q-bio.NC updates on arXiv.org
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Search, Do not Guess: Teaching Small Language Models to Be Effective Search Agents
arXiv:2604.04651v1 Announce Type: new Abstract: Agents equipped with search tools have emerged as effective solutions for knowledge-intensive tasks. While Large Language Models (LLMs) exhibit strong reasoning capabilities, their high computational cost limits practical deployment for search agents. Consequently, recent work has focused on distilling agentic behaviors from LLMs into Small Language Models (SLMs). Through comprehensive evaluation on complex multi-hop reasoning tasks, we find that
Search, Do not Guess: Teaching Small Language Models to Be Effective Search Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Unified Optimization of Source Weights and Transfer Quantities in Multi-Source Transfer Learning: An Asymptotic Framework
arXiv:2601.10779v2 Announce Type: replace-cross Abstract: In multi-source transfer learning, a key challenge lies in how to appropriately differentiate and utilize heterogeneous source tasks. However, existing multi-source methods typically focus on optimizing either the source weights or the amount of transferred samples, largely neglecting their joint consideration. In this work, we propose a theoretical framework, Unified Optimization of Weights and Quantities (UOWQ), that jointly determines
Unified Optimization of Source Weights and Transfer Quantities in Multi-Source Transfer Learning: An Asymptotic Framework
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Cell
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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
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cs.AI, q-bio.NC updates on arXiv.org
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MindCube: Spatial Mental Modeling from Limited Views
arXiv:2506.21458v2 Announce Type: replace Abstract: Can Vision-Language Models (VLMs) imagine the full scene from just a few views, like humans do? Humans form spatial mental models naturally, internal representations of unseen space, to reason about layout, perspective, and motion. Our MindCube benchmark with 21,154 questions across 3,268 images exposes this critical gap, where existing VLMs exhibit near-random performance. Using MindCube, we systematically evaluate how well VLMs build robust
MindCube: Spatial Mental Modeling from Limited Views
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Audit: A Security Analysis System for LLM Agent Applications
arXiv:2603.22853v1 Announce Type: cross Abstract: What should a developer inspect before deploying an LLM agent: the model, the tool code, the deployment configuration, or all three? In practice, many security failures in agent systems arise not from model weights alone, but from the surrounding software stack: tool functions that pass untrusted inputs to dangerous operations, exposed credentials in deployment artifacts, and over-privileged Model Context Protocol (MCP) configurations. We pres
Agent Audit: A Security Analysis System for LLM Agent Applications
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cs.AI, q-bio.NC updates on arXiv.org
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Federated Hierarchical Clustering with Automatic Selection of Optimal Cluster Numbers
arXiv:2603.12684v1 Announce Type: cross Abstract: Federated Clustering (FC) is an emerging and promising solution in exploring data distribution patterns from distributed and privacy-protected data in an unsupervised manner. Existing FC methods implicitly rely on the assumption that clients are with a known number of uniformly sized clusters. However, the true number of clusters is typically unknown, and cluster sizes are naturally imbalanced in real scenarios. Furthermore, the privacy-preservi
Federated Hierarchical Clustering with Automatic Selection of Optimal Cluster Numbers
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cs.AI, q-bio.NC updates on arXiv.org
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SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v3 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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A Lightweight Traffic Map for Efficient Anytime LaCAM*
arXiv:2603.07891v1 Announce Type: new Abstract: Multi-Agent Path Finding (MAPF) aims to compute collision-free paths for multiple agents and has a wide range of practical applications. LaCAM*, an anytime configuration-based solver, currently represents the state of the art. Recent work has explored the use of guidance paths to steer LaCAM* toward configurations that avoid traffic congestion, thereby improving solution quality. However, existing approaches rely on Frank-Wolfe-style optimization
A Lightweight Traffic Map for Efficient Anytime LaCAM*
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cs.AI, q-bio.NC updates on arXiv.org
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The Struggle Between Continuation and Refusal: A Mechanistic Analysis of the Continuation-Triggered Jailbreak in LLMs
arXiv:2603.08234v1 Announce Type: new Abstract: With the rapid advancement of large language models (LLMs), the safety of LLMs has become a critical concern. Despite significant efforts in safety alignment, current LLMs remain vulnerable to jailbreaking attacks. However, the root causes of such vulnerabilities are still poorly understood, necessitating a rigorous investigation into jailbreak mechanisms across both academic and industrial communities. In this work, we focus on a continuation-tri
The Struggle Between Continuation and Refusal: A Mechanistic Analysis of the Continuation-Triggered Jailbreak in LLMs
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cs.AI, q-bio.NC updates on arXiv.org
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AutoFigure-Edit: Generating Editable Scientific Illustration
arXiv:2603.06674v1 Announce Type: cross Abstract: High-quality scientific illustrations are essential for communicating complex scientific and technical concepts, yet existing automated systems remain limited in editability, stylistic controllability, and efficiency. We present AutoFigure-Edit, an end-to-end system that generates fully editable scientific illustrations from long-form scientific text while enabling flexible style adaptation through user-provided reference images. By combining lo
AutoFigure-Edit: Generating Editable Scientific Illustration
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cs.AI, q-bio.NC updates on arXiv.org
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Give Them an Inch and They Will Take a Mile:Understanding and Measuring Caller Identity Confusion in MCP-Based AI Systems
arXiv:2603.07473v1 Announce Type: cross Abstract: The Model Context Protocol (MCP) is an open and standardized interface that enables large language models (LLMs) to interact with external tools and services, and is increasingly adopted by AI agents. However, the security of MCP-based systems remains largely unexplored.In this work, we conduct a large-scale security analysis of MCP servers integrated within MCP clients. We show that treating MCP servers as trusted entities without authenticatin
Give Them an Inch and They Will Take a Mile:Understanding and Measuring Caller Identity Confusion in MCP-Based AI Systems
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cs.AI, q-bio.NC updates on arXiv.org
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SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v2 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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RLJP: Legal Judgment Prediction via First-Order Logic Rule-enhanced with Large Language Models
arXiv:2505.21281v2 Announce Type: replace Abstract: Legal Judgment Prediction (LJP) is a pivotal task in legal AI. Existing semantic-enhanced LJP models integrate judicial precedents and legal knowledge for high performance. But they neglect legal reasoning logic, a critical component of legal judgments requiring rigorous logical analysis. Although some approaches utilize legal reasoning logic for high-quality predictions, their logic rigidity hinders adaptation to case-specific logical framewo
RLJP: Legal Judgment Prediction via First-Order Logic Rule-enhanced with Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Practical FP4 Training for Large-Scale MoE Models on Hopper GPUs
arXiv:2603.02731v1 Announce Type: cross Abstract: Training large-scale Mixture-of-Experts (MoE) models is bottlenecked by activation memory and expert-parallel communication, yet FP4 training remains impractical on Hopper-class GPUs without native MXFP4 or NVFP4 support. In this work, we present a training recipe that enables MXFP4 efficiency for MoE models on Hopper architectures without native 4-bit computation support. A central challenge is to integrate FP4 into an existing BF16/FP8 hybrid
Practical FP4 Training for Large-Scale MoE Models on Hopper GPUs
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cs.AI, q-bio.NC updates on arXiv.org
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Continuous Telemonitoring of Heart Failure using Personalised Speech Dynamics
arXiv:2602.19674v1 Announce Type: cross Abstract: Remote monitoring of heart failure (HF) via speech signals provides a non-invasive and cost-effective solution for long-term patient management. However, substantial inter-individual heterogeneity in vocal characteristics often limits the accuracy of traditional cross-sectional classification models. To address this, we propose a Longitudinal Intra-Patient Tracking (LIPT) scheme designed to capture the trajectory of relative symptomatic changes