arXiv:2509.23067v2 Announce Type: replace-cross Abstract: The rising cost of acquiring supervised data has driven significant interest in self-improvement for large language models (LLMs). Straightforward unsupervised signals like majority voting have proven effective in generating pseudo-labels for verifiable tasks, while their applicability to unverifiable tasks (e.g., translation) is limited by the open-ended character of responses. As a result, self-evaluation mechanisms (e.g., self-judging and entropy minimization) are predominantly used to derive pseudo-labels. However, self-evaluation relying on LLMs typically incurs high computational overhead and introduces overconfidence issues due to intrinsic biases. To address these challenges, we propose a novel self-evaluation-free approach for unverifiable tasks, designed for lightweight yet effective self-improvement. Inspired by majority voting commonly employed in verifiable tasks, we propose semantic voting as a novel mechanism that relaxes the principle of hard matching (i.e., exact matching) toward soft matching (i.e., semantic similarity). Soft matching is achieved by leveraging a lightweight sentence embedding model to quantify semantic similarity, thereby mitigating excessive computational burden and intrinsic bias-associated limitations of self-evaluation. Comprehensive experiments demonstrate that our method achieves substantial gains in computational efficiency and overall better performance than self-evaluation methods across diverse model architectures and tasks.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10281-5

Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occurs during parasite infections.

arXiv:2602.19158v1 Announce Type: new Abstract: Medical foundation models generate narrative explanations but cannot quantify intervention effects, detect evidence conflicts, or validate literature claims, limiting clinical auditability. We propose causal compilation, a paradigm that transforms medical evidence from narrative text into executable code. The paradigm standardizes heterogeneous research evidence into structured estimand objects, each explicitly specifying intervention contrast, effect scale, time horizon, and target population, supporting six executable causal queries: do-calculus, counterfactual reasoning, temporal trajectories, heterogeneous effects, mechanistic decomposition, and joint interventions. We instantiate this paradigm in DoAtlas-1, compiling 1,445 effect kernels from 754 studies through effect standardization, conflict-aware graph construction, and real-world validation (Human Phenotype Project, 10,000 participants). The system achieves 98.5% canonicalization accuracy and 80.5% query executability. This paradigm shifts medical AI from text generation to executable, auditable, and verifiable causal reasoning.