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Teclistamab versus lenalidomide-dexamethasone in high-risk smoldering multiple myeloma: a randomized phase 2 trial

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04642-w

In the randomized phase 2 ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma (MM) showed higher rates of complete clinical responses in response to treatment with teclistamab compared with lenalidomide–dexamethasone, although longer follow-up is required to determine durable prevention of progression to MM.

Commensal <i>Nakaseomyces glabratus</i> migrates into prostate tumors to accelerate cancer progression

Nature Cancer, Published online: 09 September 2026; doi:10.1038/s43018-026-01229-9

Lai et al. show that Nakaseomyces glabratus is enriched in fecal and tumor samples of patients with castration-resistant prostate cancer and that administration of the fungus accelerates cancer progression in prostate cancer-bearing castrated mice.

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Cell Death Discovery, Published online: 08 September 2026; doi:10.1038/s41420-026-03339-w

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

PANDO: Efficient Multimodal AI Agents via Online Skill Distillation

arXiv:2605.24785v2 Announce Type: new Abstract: Recent advances in multimodal web agents often rely on increased inference-time computation, including rollout search, verifier passes, offline skill discovery, and specialist model stacks. This raises a central question: can a web agent become more efficient as it accumulates experience, rather than more expensive? We first analyze trajectories from VisualWebArena and identify three recurring sources of inefficiency: repeat-action loops, hidden discovery costs, and low prompt-cache reuse. We then introduce PANDO, a single-rollout online skill-distillation framework that maintains a structured Skill Library and combines progress reflection, confidence-based skill demotion, hierarchical routing, visual compression, and cache-aware prompting. On the full set of 910 VisualWebArena tasks, PANDO achieves a 58.3% success rate, outperforming SGV (54.0%) and our WALT reproduction (45.2%), while using 58% fewer tokens than SGV and 61% fewer tokens than WALT, without any pre-evaluation discovery budget. A 300-task ablation further shows that rules and routines provide most of the success gains, while routing, compression, and cache-aware prompting convert the larger skill library into lower marginal token cost. Finally, we introduce three trajectory-level efficiency metrics -- Action Repetition Rate, Step Overhead Ratio, and Prompt Cache Utilization -- to make efficiency visible beyond terminal success.

Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures

A pan-neurodegeneration atlas built from multilayer, deep proteomics of 2,279 brain samples across 6 major diseases integrates whole proteome, detergent-insoluble proteome, and posttranslational modifications to enable intra- and inter-disease comparisons to reveal disease-specific subtypes and dysregulated pathways, while identifying shared changes such as GPNMB upregulation and NPTX2 downregulation.
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