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An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Nature Cancer, Published online: 22 September 2026; doi:10.1038/s43018-026-01234-y

Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an important and targetable factor in this process.

UniWhisper: Efficient Continual Multi-task Training for Robust Universal Audio Representation

arXiv:2602.21772v2 Announce Type: replace-cross Abstract: A universal audio representation should capture fine-grained speech cues and high-level semantics for environmental sounds and music in a single encoder. Existing encoders often excel in one domain but degrade in others. We propose UniWhisper, an efficient continual multi-task training framework that casts heterogeneous audio tasks into a unified instruction and answer format. This enables standard next-token training without task-specific heads and losses. We train it on 38k hours of public audio and assess the encoder using shallow MLP probes and k-nearest neighbors (kNN) on 20 tasks spanning speech, environmental sound, and music. UniWhisper reaches normalized weighted averages of 0.81 with MLP probes and 0.61 with kNN, compared to 0.64 and 0.46 for Whisper, while retaining strong speech performance.

FastCode: Fast and Cost-Efficient Code Understanding and Reasoning

arXiv:2603.01012v2 Announce Type: replace-cross Abstract: Repository-scale code reasoning is a cornerstone of modern AI-assisted software engineering, enabling Large Language Models (LLMs) to handle complex workflows from program comprehension to complex debugging. However, balancing accuracy with context cost remains a significant bottleneck, as existing agentic approaches often waste computational resources through inefficient, iterative full-text exploration. To address this, we introduce FastCode, a framework that decouples repository exploration from content consumption. FastCode utilizes a structural scouting mechanism to navigate a lightweight semantic-structural map of the codebase, allowing the system to trace dependencies and pinpoint relevant targets without the overhead of full-text ingestion. By leveraging structure-aware navigation tools regulated by a cost-aware policy, the framework constructs high-value contexts in a single, optimized step. Extensive evaluations on the SWE-QA, LongCodeQA, LOC-BENCH, and GitTaskBench benchmarks demonstrate that FastCode consistently outperforms state-of-the-art baselines in reasoning accuracy while significantly reducing token consumption, validating the efficiency of scouting-first strategies for large-scale code reasoning. Source code is available at https://github.com/HKUDS/FastCode.
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