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cs.AI, q-bio.NC updates on arXiv.org
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Online Video Agent Harness for Long Video Understanding
arXiv:2609.12818v1 Announce Type: cross Abstract: Long video understanding often behaves like a visual needle-in-a-haystack problem: query-relevant evidence is sparsely distributed across long temporal spans, while packing dense frames into a single VLM context incurs \textit{context rot} and high cost. Existing video agents often rely on query-agnostic offline preprocessing or ad hoc tool sets, which can miss query-specific details and waste computation. In this work, we present VideoXAgent, a
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Overcoming missing data in spatial metabolomics with machine learning imputation to accelerate downstream discovery
iScience. 2026 Mar 3;29(4):115203. doi: 10.1016/j.isci.2026.115203. eCollection 2026 Apr 17.ABSTRACTMass spectrometry imaging (MSI)-based spatial metabolomics exhibits extensive missing values; yet, practical guidance on how imputation choices affect both imputation accuracy and downstream spatial analyses remains limited. In this study, we evaluated eight imputation methods, including both existing approaches and a graph convolutional network (GCN)-based method specifically designed for spatial
Overcoming missing data in spatial metabolomics with machine learning imputation to accelerate downstream discovery
iScience. 2026 Mar 3;29(4):115203. doi: 10.1016/j.isci.2026.115203. eCollection 2026 Apr 17.
ABSTRACT
Mass spectrometry imaging (MSI)-based spatial metabolomics exhibits extensive missing values; yet, practical guidance on how imputation choices affect both imputation accuracy and downstream spatial analyses remains limited. In this study, we evaluated eight imputation methods, including both existing approaches and a graph convolutional network (GCN)-based method specifically designed for spatial metabolomics data, to identify suitable approaches for spatial metabolomics. To enable comprehensive assessment, we developed an evaluation framework focusing on two objective criteria: (a) imputation accuracy and (b) preservation of spatial cluster structure. We assembled six benchmark datasets spanning mouse brain and liver, human kidney and stomach, and plant seed sections, and conducted controlled dropout simulations of missing values. Across both evaluation dimensions, including imputation accuracy and preservation of spatial cluster structure, RF ranked first overall, and GCN ranked second in both dimensions. Overall, this systematic, dual-perspective benchmark study provides guidance for selecting imputation strategies in spatial metabolomics research.
PMID:41869568 | PMC:PMC12999350 | DOI:10.1016/j.isci.2026.115203