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Beyond the Aggregation Dilemma: Prior-Retaining Decoupled Learning for Multimodal Graphs

arXiv:2605.24684v1 Announce Type: cross Abstract: Multimodal Attributed Graph Learning (MAGL) integrates intrinsic node attributes with structural topology via graph aggregation. However, as pretrained encoders evolve into Large Foundation Models (LFMs), the landscape of MAGL fundamentally shifts: under high-confidence LFM priors, mandatory aggregation introduces topological noise that overwhelms discriminative signals, triggering a counter-intuitive performance inversion where sophisticated MAGL architectures underperform simple topology-agnostic MLPs. Through systematic empirical and theoretical analysis, we identify that this inversion stems from a fundamental aggregation dilemma characterized by two concurrent pathologies: (1) Representational Pathology (SNR Degradation) - mandatory aggregation dilutes robust intrinsic features with topological noise, causing the noise penalty to outweigh its collaborative benefit; and (2) Optimization Pathology (Gradient Starvation) - topological aggregation attenuates gradient flow, while a shared task loss causes dominant modalities to prematurely suppress weaker ones. To resolve this dilemma, we propose SUPRA (Shared-Unique Prior-Retaining Architecture), a decoupled dual-pathway paradigm. SUPRA processes modality-specific features through topology-agnostic MLPs while capturing structural synergy via a lightweight shared GNN, with auxiliary deep supervision counteracting gradient starvation. Extensive evaluations demonstrate that SUPRA achieves state-of-the-art performance while requiring 3.5x lower peak GPU memory and up to 4.4x faster training time than Multimodal Graph Transformers.

Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma

12 May 2026 at 18:00

NPJ Precis Oncol. 2026 May 12;10(1):284. doi: 10.1038/s41698-026-01471-5.

ABSTRACT

Lung adenocarcinoma (LUAD) accounts for approximately 40% of non-small cell lung cancer. Although the microbiome may play a role in LUAD, a comprehensive understanding of its ecological landscape and interactions with the tumor host, particularly during early development of LUAD, remains lacking. Here we employed a multi-omic approach to assess the dynamics of the tumor microbiota-host interaction across stages of early LUAD, including benign nodules, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). We found a strong and intricate interaction between the microbiome and host immune and metabolic pathways in AIS, while microbiome-host interactions substantially diminish in MIA and IAC. Serum metabolites and CT-based radiological features, such as atropaldehyde, sterculic acid, nodule morphology and maximum nodule diameter, were closely associated with the microbiome-host interaction network, suggesting they could be non-invasive markers indicating tumor ecological and pathological changes. Multi-omic integration revealed an optimal performance in classifying individual LUAD stages, particularly between AIS and MIA that was otherwise challenging to differentiate using a single data type. Our results highlight the dynamic interaction between microbiome and host during early LUAD, which can be partially reflected in systemic metabolic and radiological manifestations, providing a novel framework for understanding early-stage LUAD.

PMID:42120518 | PMC:PMC13388699 | DOI:10.1038/s41698-026-01471-5

Rel-MOSS: Towards Imbalanced Relational Deep Learning on Relational Databases

arXiv:2603.07916v1 Announce Type: new Abstract: In recent advances, to enable a fully data-driven learning paradigm on relational databases (RDB), relational deep learning (RDL) is proposed to structure the RDB as a heterogeneous entity graph and adopt the graph neural network (GNN) as the predictive model. However, existing RDL methods neglect the imbalance problem of relational data in RDBs and risk under-representing the minority entities, leading to an unusable model in practice. In this work, we investigate, for the first time, class imbalance problem in RDB entity classification and design the relation-centric minority synthetic over-sampling GNN (Rel-MOSS), in order to fill a critical void in the current literature. Specifically, to mitigate the issue of minority-related information being submerged by majority counterparts, we design the relation-wise gating controller to modulate neighborhood messages from each individual relation type. Based on the relational-gated representations, we further propose the relation-guided minority synthesizer for over-sampling, which integrates the entity relational signatures to maintain relational consistency. Extensive experiments on 12 entity classification datasets provide compelling evidence for the superiority of Rel-MOSS, yielding an average improvement of up to 2.46% and 4.00% in terms of Balanced Accuracy and G-Mean, compared with SOTA RDL methods and classic methods for handling class imbalance.

Zero-Permission Manipulation: Can We Trust Large Multimodal Model Powered GUI Agents?

arXiv:2601.12349v2 Announce Type: replace-cross Abstract: Large multimodal model powered GUI agents are emerging as high-privilege operators on mobile platforms, entrusted with perceiving screen content and injecting inputs. However, their design operates under the implicit assumption of Visual Atomicity: that the UI state remains invariant between observation and action. We demonstrate that this assumption is fundamentally invalid in Android, creating a critical attack surface. We present Action Rebinding, a novel attack that allows a seemingly-benign app with zero dangerous permissions to rebind an agent's execution. By exploiting the inevitable observation-to-action gap inherent in the agent's reasoning pipeline, the attacker triggers foreground transitions to rebind the agent's planned action toward the target app. We weaponize the agent's task-recovery logic and Android's UI state preservation to orchestrate programmable, multi-step attack chains. Furthermore, we introduce an Intent Alignment Strategy (IAS) that manipulates the agent's reasoning process to rationalize UI states, enabling it to bypass verification gates (e.g., confirmation dialogs) that would otherwise be rejected. We evaluate Action Rebinding Attacks on six widely-used Android GUI agents across 15 tasks. Our results demonstrate a 100% success rate for atomic action rebinding and the ability to reliably orchestrate multi-step attack chains. With IAS, the success rate in bypassing verification gates increases (from 0% to up to 100%). Notably, the attacker application requires no sensitive permissions and contains no privileged API calls, achieving a 0% detection rate across malware scanners (e.g., VirusTotal). Our findings reveal a fundamental architectural flaw in current agent-OS integration and provide critical insights for the secure design of future agent systems. To access experimental logs and demonstration videos, please contact yi_qian@smail.nju.edu.cn.
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