npj Digital Medicine, Published online: 05 October 2026; doi:10.1038/s41746-026-03232-x

Standardized pre-consultation by a large language model agent vs ophthalmology residents: a randomized clinical trial

arXiv:2605.25188v1 Announce Type: new Abstract: Multi-agent LLM systems improve reasoning by combining outputs from multiple agents, but interaction-heavy methods can introduce error propagation and high communication overhead. When agents exchange raw responses or reasoning traces, incorrect intermediate reasoning may be adopted and amplified, leading to confident but wrong consensus; multi-round communication also increases token consumption, latency, and inference cost. In this paper, we propose a controlled-communication coordination framework named DarkForest. DarkForest first keeps agents independent, so each agent produces an answer without seeing the others' outputs. It then parses the raw responses into structured candidate records, groups semantically equivalent candidates into clusters, and estimates a calibrated belief distribution over these clusters using agent reliability, confidence, parse quality, support-pattern reliability, and independence corrections. A coordinator receives only policy-permitted evidence from this belief state with controlled communication. Experiments on six reasoning benchmarks show that DarkForest achieves leading overall quality, improves the strongest baseline by up to 30.7\% on benchmark metrics, and reduces token consumption by up to $6.5\times$ compared with communication-heavy baselines.

The maturation of non-spatial grid-cell-like neural codes in the entorhinal cortex provides a foundational scaffold for Piaget’s cognitive development theory, uncovering how structured knowledge schemas support inferential reasoning, assimilate new information, and track fluid intelligence from ages 8 to 25.

arXiv:2604.03630v1 Announce Type: new Abstract: Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present \textbf{\ours} (\textbf{S}patial \textbf{T}ranscriptomics and hist\textbf{O}logy \textbf{R}epresentation \textbf{M}odel), a foundation model trained on 1.2 million spatially resolved transcriptomic profiles with matched histology across 18 organs. Using a hierarchical architecture integrating morphological features, gene expression, and spatial context, STORM bridges imaging and omics through robust molecular--morphological representations. STORM enhances spatial domain discovery, producing biologically coherent tissue maps, and outperforms existing methods in predicting spatial gene expression from H\&E images across 11 tumor types. The model is platform-agnostic, performing consistently across Visium, Xenium, Visium HD, and CosMx. Applied to 23 independent cohorts comprising 7,245 patients, STORM significantly improves immunotherapy response prediction and prognostication over established biomarkers, providing a scalable framework for spatially informed discovery and clinical precision medicine.

arXiv:2508.16703v3 Announce Type: replace-cross Abstract: On-device running Large Language Models (LLMs) is nowadays a critical enabler towards preserving user privacy. We observe that the attention operator falls back from the special-purpose NPU to the general-purpose CPU/GPU because of quantization sensitivity in state-of-the-art frameworks. This fallback results in a degraded user experience and increased complexity in system scheduling. To this end, this paper presents shadowAttn, a system-algorithm codesigned sparse attention module with minimal reliance on CPU/GPU by only sparsely calculating the attention on a tiny portion of tokens. The key idea is to hide the overhead of estimating the important tokens with a NPU-based pilot compute. Further, shadowAttn proposes insightful techniques such as NPU compute graph bucketing, head-wise NPU-CPU/GPU pipeline and per-head fine-grained sparsity ratio to achieve high accuracy and efficiency. shadowAttn delivers the best performance with highly limited CPU/GPU resource; it requires much less CPU/GPU resource to deliver on-par performance of SoTA frameworks.

arXiv:2604.01561v1 Announce Type: cross Abstract: We present ReFlow, a unified framework for monocular dynamic scene reconstruction that learns 3D motion in a novel self-correction manner from raw video. Existing methods often suffer from incomplete scene initialization for dynamic regions, leading to unstable reconstruction and motion estimation, which often resorts to external dense motion guidance such as pre-computed optical flow to further stabilize and constrain the reconstruction of dynamic components. However, this introduces additional complexity and potential error propagation. To address these issues, ReFlow integrates a Complete Canonical Space Construction module for enhanced initialization of both static and dynamic regions, and a Separation-Based Dynamic Scene Modeling module that decouples static and dynamic components for targeted motion supervision. The core of ReFlow is a novel self-correction flow matching mechanism, consisting of Full Flow Matching to align 3D scene flow with time-varying 2D observations, and Camera Flow Matching to enforce multi-view consistency for static objects. Together, these modules enable robust and accurate dynamic scene reconstruction. Extensive experiments across diverse scenarios demonstrate that ReFlow achieves superior reconstruction quality and robustness, establishing a novel self-correction paradigm for monocular 4D reconstruction.

arXiv:2604.01941v1 Announce Type: cross Abstract: Image captioning for Early Childhood Education (ECE) is essential for automated activity understanding and educational assessment. However, existing methods face two key challenges. First, the lack of large-scale, domain-specific datasets limits the model's ability to capture fine-grained semantic concepts unique to ECE scenarios, resulting in generic and imprecise descriptions. Second, conventional training paradigms exhibit limitations in enhancing professional object description capability, as supervised learning tends to favor high-frequency expressions, while reinforcement learning may suffer from unstable optimization on difficult samples. To address these limitations, we introduce ECAC, a large-scale benchmark for ECE daily activity image captioning, comprising 256,121 real-world images annotated with expert-level captions and fine-grained labels. ECAC is further equipped with a domain-oriented evaluation protocol, the Teaching Toy Recognition Score (TTS), to explicitly measure professional object naming accuracy. Furthermore, we propose RSRS (Reward-Conditional Switch of Reinforcement Learning and Supervised Fine-Tuning), a hybrid training framework that dynamically alternates between RL and supervised optimization. By rerouting hard samples with zero rewards to supervised fine-tuning, RSRS effectively mitigates advantage collapse and enables stable optimization for fine-grained recognition. Leveraging ECAC and RSRS, we develop KinderMM-Cap-3B, a domain-adapted multimodal large language model. Extensive experiments demonstrate that our model achieves a TTS of 51.06, substantially outperforming state-of-the-art baselines while maintaining superior caption quality, highlighting its potential for specialized educational applications.

arXiv:2302.10426v3 Announce Type: replace Abstract: Trustworthy process monitoring seeks to build an accurate and interpretable monitoring framework, which is critical for ensuring the safety of energy conversion plant (ECP) that operates under extreme working conditions such as high pressure and temperature. Contemporary self-attentive models, however, fall short in this domain for two main reasons. First, they rely on step-wise correlations that fail to involve physically meaningful semantics in ECP logs, resulting in suboptimal accuracy and interpretability. Second, attention matrices are frequently cluttered with spurious correlations that obscure physically meaningful ones, further impeding effective interpretation. To overcome these issues, we propose AttentionMixer, a framework aimed at improving both accuracy and interpretability of existing methods and establish a trustworthy ECP monitoring framework. Specifically, to tackle the first issue, we employ a spatial adaptive message passing block to capture variate-wise correlations. This block is coupled with a temporal adaptive message passing block through an \textit{mixing} operator, yielding a multi-faceted representation of ECP logs accounting for both step-wise and variate-wise correlations. Concurrently, to tackle the second issue, we employ a sparse message passing regularizer to filter out spurious correlations. We validate the efficacy of AttentionMixer using two real-world datasets from the radiation monitoring network for Chinese nuclear power plants.

arXiv:2511.20008v2 Announce Type: replace-cross Abstract: Pedestrian crossing intention prediction is essential for the deployment of autonomous vehicles (AVs) in urban environments. Ideal prediction provides AVs with critical environmental cues, thereby reducing the risk of pedestrian-related collisions. However, the prediction task is challenging due to the diverse nature of pedestrian behavior and its dependence on multiple contextual factors. This paper proposes a multimodal fusion network that leverages seven modality features from both visual and motion branches, aiming to effectively extract and integrate complementary cues across different modalities. Specifically, motion and visual features are extracted from the raw inputs using multiple Transformer-based extraction modules. Depth-guided attention module leverages depth information to guide attention towards salient regions in another modality through comprehensive spatial feature interactions. To account for the varying importance of different modalities and frames, modality attention and temporal attention are designed to selectively emphasize informative modalities and effectively capture temporal dependencies. Extensive experiments on the JAAD dataset validate the effectiveness of the proposed network, achieving superior performance compared to the baseline methods.

arXiv:2603.13019v1 Announce Type: cross Abstract: Agentic reinforcement learning (RL) has emerged as a transformative workload in cloud clusters, enabling large language models (LLMs) to solve complex problems through interactions with real world. However, unlike traditional RL, agentic RL demands substantial external cloud resources, e.g., CPUs for code execution and GPUs for reward models, that exist outside the primary training cluster. Existing agentic RL framework typically rely on static over-provisioning, i.e., resources are often tied to long-lived trajectories or isolated by tasks, which leads to severe resource inefficiency. We propose the action-level orchestration, and incorporate it into ARL-Tangram, a unified resource management system that enables fine-grained external resource sharing and elasticity. ARL-Tangram utilizes a unified action-level formulation and an elastic scheduling algorithm to minimize action completion time (ACT) while satisfying heterogeneous resource constraints. Further, heterogeneous resource managers are tailored to efficiently support the action-level execution on resources with heterogeneous characteristics and topologies. Evaluation on real-world agentic RL tasks demonstrates that ARL-Tangram improves average ACT by up to 4.3$\times$, speeds up the step duration of RL training by up to 1.5$\times$, and saves the external resources by up to 71.2$\%$. This system has been deployed to support the training of the MiMo series models.

arXiv:2603.07452v1 Announce Type: cross Abstract: Backdoor mechanisms have traditionally been studied as security threats that compromise the integrity of machine learning models. However, the same mechanism -- the conditional activation of specific behaviors through input triggers -- can also serve as a controllable and auditable interface for trustworthy model behavior. In this work, we present \textbf{Backdoor4Good (B4G)}, a unified benchmark and framework for \textit{beneficial backdoor} applications in large language models (LLMs). Unlike conventional backdoor studies focused on attacks and defenses, B4G repurposes backdoor conditioning for Beneficial Tasks that enhance safety, controllability, and accountability. It formalizes beneficial backdoor learning under a triplet formulation $(T, A, U)$, representing the \emph{Trigger}, \emph{Activation mechanism}, and \emph{Utility function}, and implements a benchmark covering four trust-centric applications. Through extensive experiments across Llama3.1-8B, Gemma-2-9B, Qwen2.5-7B, and Llama2-13B, we show that beneficial backdoors can achieve high controllability, tamper-resistance, and stealthiness while preserving clean-task performance. Our findings demonstrate new insights that backdoors need not be inherently malicious; when properly designed, they can serve as modular, interpretable, and beneficial building blocks for trustworthy AI systems. Our code and datasets are available at https://github.com/bboylyg/BackdoorLLM/B4G.

arXiv:2603.07496v1 Announce Type: cross Abstract: Artificial Intelligence (AI) agents have evolved from passive predictive tools into active entities capable of autonomous decision-making and environmental interaction, driven by the reasoning capabilities of Large Language Models (LLMs). However, this evolution has introduced critical security vulnerabilities that existing frameworks fail to address. The Hierarchical Autonomy Evolution (HAE) framework organizes agent security into three tiers: Cognitive Autonomy (L1) targets internal reasoning integrity; Execution Autonomy (L2) covers tool-mediated environmental interaction; Collective Autonomy (L3) addresses systemic risks in multi-agent ecosystems. We present a taxonomy of threats spanning cognitive manipulation, physical environment disruption, and multi-agent systemic failures, and evaluate existing defenses while identifying key research gaps. The findings aim to guide the development of multilayered, autonomy-aware defense architectures for trustworthy AI agent systems.

arXiv:2603.07516v1 Announce Type: cross Abstract: Interaction is one of the core abilities of humanoid robots. However, most existing frameworks focus on non-interactive whole-body control, which limits their practical applicability. In this work, we develop InterReal, a unified physics-based imitation learning framework for Real-world human-object Interaction (HOI) control. InterReal enables humanoid robots to track HOI reference motions, facilitating the learning of fine-grained interactive skills and their deployment in real-world settings. Within this framework, we first introduce a HOI motion data augmentation scheme with hand-object contact constraints, and utilize the augmented motions to improve policy stability under object perturbations. Second, we propose an automatic reward learner to address the challenge of large-scale reward shaping. A meta-policy guided by critical tracking error metrics explores and allocates reward signals to the low-level reinforcement learning objective, which enables more effective learning of interactive policies. Experiments on HOI tasks of box-picking and box-pushing demonstrate that InterReal achieves the best tracking accuracy and the highest task success rate compared to recent baselines. Furthermore, we validate the framework on the real-world robot Unitree G1, which demonstrates its practical effectiveness and robustness beyond simulation.

arXiv:2603.07540v1 Announce Type: cross Abstract: Unified multimodal models hold the promise of generating extensive, interleaved narratives, weaving text and imagery into coherent long-form stories. However, current systems suffer from a critical reliability gap: as sequences grow, generation quality rapidly collapses. In this work, we investigate the mechanism behind this failure and argue that it is distinct from standard long-context challenges. We reveal that in generation, accumulated visual history acts as a source of active pollution, a decay governed specifically by the number of image events rather than raw token count. We identify a structural vulnerability where dense visual tokens overwhelm the attention mechanism, creating noise that distorts future synthesis. Guided by these mechanistic insights, we propose UniLongGen, a training-free inference strategy that prioritizes safe conditioning over total recall. Instead of retaining all history, UniLongGen dynamically curates the model's memory, identifying and discarding interfering visual signals based on the model's own internal relevance rankings. Extensive experiments demonstrate that this active forgetting approach is essential for stability: UniLongGen significantly outperforms baselines in long-horizon fidelity and consistency, while simultaneously reducing memory footprint and inference time.

arXiv:2506.07177v2 Announce Type: replace-cross Abstract: Advancements in diffusion models have significantly improved video quality, directing attention to fine-grained controllability. However, many existing methods depend on fine-tuning large-scale video models for specific tasks, which becomes increasingly impractical as model sizes continue to grow. In this work, we present Frame Guidance, a training-free guidance for controllable video generation based on frame-level signals, such as keyframes, style reference images, sketches, or depth maps. For practical training-free guidance, we propose a simple latent processing method that dramatically reduces memory usage, and apply a novel latent optimization strategy designed for globally coherent video generation. Frame Guidance enables effective control across diverse tasks, including keyframe guidance, stylization, and looping, without any training, compatible with any video models. Experimental results show that Frame Guidance can produce high-quality controlled videos for a wide range of tasks and input signals.

arXiv:2602.18782v1 Announce Type: cross Abstract: Defending LLMs against adversarial jailbreak attacks remains an open challenge. Existing defenses rely on binary classifiers that fail when adversarial input falls outside the learned decision boundary, and repeated fine-tuning is computationally expensive while potentially degrading model capabilities. We propose MANATEE, an inference-time defense that uses density estimation over a benign representation manifold. MANATEE learns the score function of benign hidden states and uses diffusion to project anomalous representations toward safe regions--requiring no harmful training data and no architectural modifications. Experiments across Mistral-7B-Instruct, Llama-3.1-8B-Instruct, and Gemma-2-9B-it demonstrate that MANATEE reduce Attack Success Rate by up to 100\% on certain datasets, while preserving model utility on benign inputs.

arXiv:2602.19320v1 Announce Type: cross Abstract: Agentic memory systems enable large language model (LLM) agents to maintain state across long interactions, supporting long-horizon reasoning and personalization beyond fixed context windows. Despite rapid architectural development, the empirical foundations of these systems remain fragile: existing benchmarks are often underscaled, evaluation metrics are misaligned with semantic utility, performance varies significantly across backbone models, and system-level costs are frequently overlooked. This survey presents a structured analysis of agentic memory from both architectural and system perspectives. We first introduce a concise taxonomy of MAG systems based on four memory structures. Then, we analyze key pain points limiting current systems, including benchmark saturation effects, metric validity and judge sensitivity, backbone-dependent accuracy, and the latency and throughput overhead introduced by memory maintenance. By connecting the memory structure to empirical limitations, this survey clarifies why current agentic memory systems often underperform their theoretical promise and outlines directions for more reliable evaluation and scalable system design.

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.