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cs.AI, q-bio.NC updates on arXiv.org
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BlueLM-GUI Technical Report: A Real-Device-Centric Flywheel for Self-Improving Mobile GUI Agents
arXiv:2609.12394v1 Announce Type: new Abstract: Mobile GUI agents are shifting from multi-module frameworks to native models trained end-to-end, yet industrial deployment faces three persistent gaps. Sandbox training produces a distribution mismatch with production environments; expensive real-device failures remain underutilized; and fixed benchmarks saturate, losing the power to guide iteration. We present BlueLM-GUI, a 35B-A3B mobile GUI agent built as a real-device-centric flywheel that clo
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Nature - Issue - nature.com science feeds
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TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8
TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.-
(Multiomics OR Omics) AND (Pancreatic)
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Itaconate and its derivatives in human health and diseases
Signal Transduct Target Ther. 2026 Sep 4;11(1):363. doi: 10.1038/s41392-026-02936-6.ABSTRACTMetabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated through the decarboxylation of cis aconitate, acts as an immunometabolic brake that engages
Itaconate and its derivatives in human health and diseases
Signal Transduct Target Ther. 2026 Sep 4;11(1):363. doi: 10.1038/s41392-026-02936-6.
ABSTRACT
Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated through the decarboxylation of cis aconitate, acts as an immunometabolic brake that engages multiple regulatory pathways to sustain the dynamic equilibrium between inflammation and tissue homeostasis. Across a broad spectrum of pathological conditions, including infectious diseases, metabolic disorders, ischemia‒reperfusion injury, neurodegenerative diseases, autoimmune disorders, and cancers, itaconate and its derivatives generally exert anti-inflammatory and cytoprotective effects. However, within specific microenvironments, these molecules may also be exploited by pathogens to evade immune clearance or promote immunosuppressive and protumorigenic responses. Future studies should further elucidate tissue- and lineage-specific functions, define bidirectional regulatory mechanisms, and optimize the pharmacokinetic properties of itaconate derivatives. With the advancement of multiomics integration, systems immunology, rational drug design, and engineered itaconate delivery technologies, the IRG1/ACOD1-itaconate axis and derivative-based therapeutic strategies are poised to emerge as key metabolic checkpoints and therapeutic targets in inflammatory-, metabolic-, immune-, and cancer-related diseases.
PMID:42693110 | PMC:PMC13542262 | DOI:10.1038/s41392-026-02936-6
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Omics in Gastric
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CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT-THBS1 axis and epigenetic reactivation by decitabine
Clin Transl Med. 2026 Sep;16(9):e70784. doi: 10.1002/ctm2.70784.ABSTRACTBACKGROUND: As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour-suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1-mediated tumour suppression in gastric cancer (GC), its relationship with the tumour-associated immune microenvironment, and pharmacological strategies to restore its exp
CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT-THBS1 axis and epigenetic reactivation by decitabine
Clin Transl Med. 2026 Sep;16(9):e70784. doi: 10.1002/ctm2.70784.
ABSTRACT
BACKGROUND: As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour-suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1-mediated tumour suppression in gastric cancer (GC), its relationship with the tumour-associated immune microenvironment, and pharmacological strategies to restore its expression remain poorly understood.
METHODS: CDO1 expression and prognosis were evaluated by multi-omics and tissue microarray analyses. Tumour microenvironment and immune infiltration were analyzed using ESTIMATE and ssGSEA. Downstream pathways and interacting proteins were identified by transcriptomics, co-immunoprecipitation, and GST pull-down. CDO1 function was assessed by proliferation, apoptosis, and migration assays in gain- and loss-of-function models. In vivo tumorigenesis and CDO1-dependent decitabine efficacy were evaluated by subcutaneous xenografts. Patient-derived organoids were used to assess decitabine sensitivity and 5-FU synergy.
RESULTS: Compared with normal controls, CDO1 expression was notably decreased in GC tissues, and its low expression was strongly linked to unfavourable prognosis, supporting its utility as a biomarker for prognosis. Elevated CDO1 levels correlated with an immune-active tumour microenvironment and reduced metastatic signatures. Mechanistically, CDO1 directly bound to PI3K p85α, disrupting p85α-p110α dimerization, thereby attenuating PI3K/AKT phosphorylation and downregulating THBS1 expression. CDO1 overexpression led to reduced proliferation, invasiveness, and EMT, accompanied by increased apoptosis. These effects were reversed by PI3K activation or THBS1 co-overexpression. Decitabine was identified as an agent that epigenetically restores CDO1 expression. Critically, CDO1 knockdown significantly attenuated the anti-tumour efficacy of decitabine in vivo, confirming that decitabine acts primarily through CDO1 reactivation. Decitabine synergized with 5-FU in both organoids and xenografts.
CONCLUSIONS: Our data identify CDO1 as both a biomarker for prognosis and a tumour suppressor in gastric cancer. They reveal a CDO1-PI3K/AKT-THBS1 signalling axis and support the epigenetic reactivation of CDO1 by decitabine as a translatable therapeutic strategy.
KEY POINTS: CDO1 is frequently downregulated in gastric cancer and serves as an independent favourable prognostic biomarker. CDO1 directly binds PI3K p85α, disrupting p85α-p110α dimerization to suppress the PI3K/AKT-THBS1 signalling axis. Decitabine epigenetically restores CDO1 expression, and its anti-tumour activity is critically CDO1-dependent in vivo. Combining decitabine with 5-FU synergistically overcomes gastric cancer growth in patient-derived organoids and subcutaneous xenograft models.
PMID:42670236 | PMC:PMC13527532 | DOI:10.1002/ctm2.70784
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cs.AI, q-bio.NC updates on arXiv.org
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Palette: A Modular, Controllable, and Efficient Framework for On-demand Authorized Safety Alignment Relaxation in LLMs
arXiv:2605.24154v1 Announce Type: new Abstract: Current safety alignment of foundation models largely follows a \emph{one-size-fits-all} paradigm, applying the same refusal policy across users and contexts. As a result, models may refuse requests that are unsafe for general users but legitimate for authorized professionals, limiting helpfulness in specialized professional settings. Existing approaches either require costly realignment or rely on inference-time steering that suffers from impreci
Palette: A Modular, Controllable, and Efficient Framework for On-demand Authorized Safety Alignment Relaxation in LLMs
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cs.AI, q-bio.NC updates on arXiv.org
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ActQuant: Sub-4-bit Action-Guided Quantization for Vision-Language-Action Models
arXiv:2605.24011v1 Announce Type: cross Abstract: Vision-Language-Action (VLA) models exhibit remarkable action generation for embodied intelligence, but their heavy compute make deployment on edge platforms impractical. Aggressive, sub-4-bit weight quantization is the natural solution, yet existing post-training quantization (PTQ) methods suffer severe performance degradation in this regime. To address this, we introduce ActQuant, an action-guided mixed-precision PTQ framework that operates in
ActQuant: Sub-4-bit Action-Guided Quantization for Vision-Language-Action Models
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Nature - Issue - nature.com science feeds
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De novo design of quasisymmetric two-component protein cages
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.
De novo design of quasisymmetric two-component protein cages
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0
Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.-
Nature - Issue - nature.com science feeds
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Design of one-component quasisymmetric protein nanocages
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10554-zQuasisymmetry could arise from spontaneous symmetry breaking in a system of strongly interacting building blocks with programmed curvatures, and this principle, coupled with a design approach, can generate a rich array of quasisymmetric assemblies.
Design of one-component quasisymmetric protein nanocages
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10554-z
Quasisymmetry could arise from spontaneous symmetry breaking in a system of strongly interacting building blocks with programmed curvatures, and this principle, coupled with a design approach, can generate a rich array of quasisymmetric assemblies.-
cs.AI, q-bio.NC updates on arXiv.org
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When Should a Robot Think? Resource-Aware Reasoning via Reinforcement Learning for Embodied Robotic Decision-Making
arXiv:2603.16673v3 Announce Type: replace-cross Abstract: Embodied robotic systems increasingly rely on large language model (LLM)-based agents to support high-level reasoning, planning, and decision-making during interactions with the environment. However, invoking LLM reasoning introduces substantial computational latency and resource overhead, which can interrupt action execution and reduce system reliability. Excessive reasoning may delay actions, while insufficient reasoning often leads to
When Should a Robot Think? Resource-Aware Reasoning via Reinforcement Learning for Embodied Robotic Decision-Making
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Omics in Gastric
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Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution
NPJ Precis Oncol. 2026 Mar 31. doi: 10.1038/s41698-026-01394-1. Online ahead of print.ABSTRACTVDAC2's known role in cancer and immune regulation via enhancing the CD8+ T cell-mediated killing, and it is worth systematically digging out the role of VDAC2 in pan-cancer based on this research. Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomic analyses were utilized to explore the role of VDAC2 from multiple perspectives in pan-cancers. RT-PCR, cell co-culture, CCK-8 assay,
Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution
NPJ Precis Oncol. 2026 Mar 31. doi: 10.1038/s41698-026-01394-1. Online ahead of print.
ABSTRACT
VDAC2's known role in cancer and immune regulation via enhancing the CD8+ T cell-mediated killing, and it is worth systematically digging out the role of VDAC2 in pan-cancer based on this research. Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomic analyses were utilized to explore the role of VDAC2 from multiple perspectives in pan-cancers. RT-PCR, cell co-culture, CCK-8 assay, Transwell invasion assays, and ELISA were performed to validate the expression level and biological function. VDAC2 was upregulated in the majority of pan-cancers, and functional enrichment analyses displayed that VDAC2 may take part in the biological progress of energy metabolism, mitochondrial damage and cell proliferation. The landscape of VDAC2 expression and immune infiltration was constructed, and the VDAC2-BAK1-IFNγ pathway was identified in digestive cancer. VDAC2 had the potential to serve as a novel prognostic, screening cancer indicator and immune therapeutic target sensitive to various drugs. Overexpression of VDAC2 significantly promoted gastric cancer cell proliferation, invasion and immune invasion, as validated in vitro experiments. In short, our pan-cancer analysis constructed a comprehensive landscape of VDAC2's oncogenic role, establishing VDAC2 + -BAK1-IFNγ as an important pathway in tumor progression and immune evasion. VDAC2 emerges not only as a valuable prognostic biomarker but also as a promising novel therapeutic target.
PMID:41917254 | DOI:10.1038/s41698-026-01394-1
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution
NPJ Precis Oncol. 2026 Mar 31. doi: 10.1038/s41698-026-01394-1. Online ahead of print.ABSTRACTVDAC2's known role in cancer and immune regulation via enhancing the CD8+ T cell-mediated killing, and it is worth systematically digging out the role of VDAC2 in pan-cancer based on this research. Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomic analyses were utilized to explore the role of VDAC2 from multiple perspectives in pan-cancers. RT-PCR, cell co-culture, CCK-8 assay,
Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution
NPJ Precis Oncol. 2026 Mar 31. doi: 10.1038/s41698-026-01394-1. Online ahead of print.
ABSTRACT
VDAC2's known role in cancer and immune regulation via enhancing the CD8+ T cell-mediated killing, and it is worth systematically digging out the role of VDAC2 in pan-cancer based on this research. Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomic analyses were utilized to explore the role of VDAC2 from multiple perspectives in pan-cancers. RT-PCR, cell co-culture, CCK-8 assay, Transwell invasion assays, and ELISA were performed to validate the expression level and biological function. VDAC2 was upregulated in the majority of pan-cancers, and functional enrichment analyses displayed that VDAC2 may take part in the biological progress of energy metabolism, mitochondrial damage and cell proliferation. The landscape of VDAC2 expression and immune infiltration was constructed, and the VDAC2-BAK1-IFNγ pathway was identified in digestive cancer. VDAC2 had the potential to serve as a novel prognostic, screening cancer indicator and immune therapeutic target sensitive to various drugs. Overexpression of VDAC2 significantly promoted gastric cancer cell proliferation, invasion and immune invasion, as validated in vitro experiments. In short, our pan-cancer analysis constructed a comprehensive landscape of VDAC2's oncogenic role, establishing VDAC2 + -BAK1-IFNγ as an important pathway in tumor progression and immune evasion. VDAC2 emerges not only as a valuable prognostic biomarker but also as a promising novel therapeutic target.
PMID:41917254 | DOI:10.1038/s41698-026-01394-1
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cs.AI, q-bio.NC updates on arXiv.org
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CaP-X: A Framework for Benchmarking and Improving Coding Agents for Robot Manipulation
arXiv:2603.22435v1 Announce Type: cross Abstract: "Code-as-Policy" considers how executable code can complement data-intensive Vision-Language-Action (VLA) methods, yet their effectiveness as autonomous controllers for embodied manipulation remains underexplored. We present CaP-X, an open-access framework for systematically studying Code-as-Policy agents in robot manipulation. At its core is CaP-Gym, an interactive environment in which agents control robots by synthesizing and executing program
CaP-X: A Framework for Benchmarking and Improving Coding Agents for Robot Manipulation
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cs.AI, q-bio.NC updates on arXiv.org
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From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG
arXiv:2603.03292v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields. While Retrieval-Augmented Generation (RAG) mitigates these issues, existing methods rely on noisy token-level signals and lack the multi-round refinement required for complex reasoning. In the paper, we propose MA-RAG (Multi-Round Agentic
From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG
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cs.AI, q-bio.NC updates on arXiv.org
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From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG
arXiv:2603.03292v1 Announce Type: cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields. While Retrieval-Augmented Generation (RAG) mitigates these issues, existing methods rely on noisy token-level signals and lack the multi-round refinement required for complex reasoning. In the paper, we propose **MA-RAG** (**M**ulti-Round **A**ge
From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG
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cs.AI, q-bio.NC updates on arXiv.org
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CubeComposer: Spatio-Temporal Autoregressive 4K 360{\deg} Video Generation from Perspective Video
arXiv:2603.04291v1 Announce Type: cross Abstract: Generating high-quality 360{\deg} panoramic videos from perspective input is one of the crucial applications for virtual reality (VR), whereby high-resolution videos are especially important for immersive experience. Existing methods are constrained by computational limitations of vanilla diffusion models, only supporting $\leq$ 1K resolution native generation and relying on suboptimal post super-resolution to increase resolution. We introduce C
CubeComposer: Spatio-Temporal Autoregressive 4K 360{\deg} Video Generation from Perspective Video
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cs.AI, q-bio.NC updates on arXiv.org
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GLEAN: Grounded Lightweight Evaluation Anchors for Contamination-Aware Tabular Reasoning
arXiv:2603.02212v1 Announce Type: cross Abstract: Tabular reasoning benchmarks mix semantic inference, numerical computation, and brittle table formatting, yet evaluations for small models remain vulnerable to contamination, dataset artifacts, and retrieval failures. We propose GLEAN, a lightweight evaluation protocol that integrates contamination-aware probes, weak-supervision governance, retrieval-reasoning diagnostics, and structured error attribution under tight hardware constraints. We eva
GLEAN: Grounded Lightweight Evaluation Anchors for Contamination-Aware Tabular Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Proactive Guiding Strategy for Item-side Fairness in Interactive Recommendation
arXiv:2603.03094v1 Announce Type: cross Abstract: Item-side fairness is crucial for ensuring the fair exposure of long-tail items in interactive recommender systems. Existing approaches promote the exposure of long-tail items by directly incorporating them into recommended results. This causes misalignment between user preferences and the recommended long-tail items, which hinders long-term user engagement and reduces the effectiveness of recommendations. We aim for a proactive fairness-guiding
Proactive Guiding Strategy for Item-side Fairness in Interactive Recommendation
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cs.AI, q-bio.NC updates on arXiv.org
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A Very Big Video Reasoning Suite
arXiv:2602.20159v1 Announce Type: cross Abstract: Rapid progress in video models has largely focused on visual quality, leaving their reasoning capabilities underexplored. Video reasoning grounds intelligence in spatiotemporally consistent visual environments that go beyond what text can naturally capture, enabling intuitive reasoning over spatiotemporal structure such as continuity, interaction, and causality. However, systematically studying video reasoning and its scaling behavior is hindere
A Very Big Video Reasoning Suite
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cs.AI, q-bio.NC updates on arXiv.org
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Diversity-Incentivized Exploration for Versatile Reasoning
arXiv:2509.26209v2 Announce Type: replace Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) has emerged as a crucial paradigm for incentivizing reasoning capabilities in Large Language Models (LLMs). Due to vast state-action spaces and reward sparsity in reasoning tasks, existing methods often struggle with deficient exploration and poor sample efficiency. In the paper, we propose \textbf{DIVER} (\textbf{D}iversity-\textbf{I}ncentivized Exploration for \textbf{V}ersatil\textbf{E}
Diversity-Incentivized Exploration for Versatile Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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WiSparse: Boosting LLM Inference Efficiency with Weight-Aware Mixed Activation Sparsity
arXiv:2602.14452v1 Announce Type: cross Abstract: Large Language Models (LLMs) offer strong capabilities but incur high inference costs due to dense computation and memory access. Training-free activation sparsity is a promising approach for efficient LLM inference, yet existing methods often rely solely on activation information and uniform sparsity ratios. This overlooks the critical interplay with weights and inter-block sensitivity variation, leading to suboptimal performance. We identify t