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cs.AI, q-bio.NC updates on arXiv.org
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AI Model Modulation with Logits Redistribution
arXiv:2603.12755v1 Announce Type: new Abstract: Large-scale models are typically adapted to meet the diverse requirements of model owners and users. However, maintaining multiple specialized versions of the model is inefficient. In response, we propose AIM, a novel model modulation paradigm that enables a single model to exhibit diverse behaviors to meet the specific end requirements. AIM enables two key modulation modes: utility and focus modulations. The former provides model owners with dyna
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Omics in Gastric
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FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.ABSTRACTGastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined w
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.
ABSTRACT
Gastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined with molecular assays (Co-IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt/β-catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224-254) of Gβ2, disrupting Gβγ-Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the β-catenin-destruction complex (GSK3 β-APC-Axin1), leading to β-catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the Gβ2-Dvl1 axis to activate Wnt/β-catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.
PMID:41808415 | PMC:PMC12976582 | DOI:10.1096/fj.202503587R
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cs.AI, q-bio.NC updates on arXiv.org
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CDRRM: Contrast-Driven Rubric Generation for Reliable and Interpretable Reward Modeling
arXiv:2603.08035v1 Announce Type: new Abstract: Reward modeling is essential for aligning Large Language Models(LLMs) with human preferences, yet conventional reward models suffer from poor interpretability and heavy reliance on costly expert annotations. While recent rubric-based approaches enhance evaluation transparency, they lack systematic quality control, yielding noisy and redundant criteria, failing to mitigate persistent biases (e.g., verbosity, position) in LLM evaluators, and creatin
CDRRM: Contrast-Driven Rubric Generation for Reliable and Interpretable Reward Modeling
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cs.AI, q-bio.NC updates on arXiv.org
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HumanLM: Simulating Users with State Alignment Beats Response Imitation
arXiv:2603.03303v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly used to simulate how specific users respond to a given context, enabling more user-centric applications that rely on user feedback. However, existing user simulators mostly imitate surface-level patterns and language styles, which fail to reflect the underlying states of real users (e.g., beliefs and emotions). To address these limitations, we propose a novel training framework, HumanLM, which builds
HumanLM: Simulating Users with State Alignment Beats Response Imitation
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cs.AI, q-bio.NC updates on arXiv.org
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ReportLogic: Evaluating Logical Quality in Deep Research Reports
arXiv:2602.18446v1 Announce Type: cross Abstract: Users increasingly rely on Large Language Models (LLMs) for Deep Research, using them to synthesize diverse sources into structured reports that support understanding and action. In this context, the practical reliability of such reports hinges on logical quality: whether the report's claims and arguments are explicitly supported and can be trusted as a basis for downstream use, rather than merely appearing fluent or informative. However, curren
ReportLogic: Evaluating Logical Quality in Deep Research Reports
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cs.AI, q-bio.NC updates on arXiv.org
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City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
arXiv:2602.19326v1 Announce Type: cross Abstract: As cities evolve over time, challenges such as traffic congestion and functional imbalance increasingly necessitate urban renewal through efficient modification of existing plans, rather than complete re-planning. In practice, even minor urban changes require substantial manual effort to redraw geospatial layouts, slowing the iterative planning and decision-making procedure. Motivated by recent advances in agentic systems and multimodal reasonin
City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
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cs.AI, q-bio.NC updates on arXiv.org
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Mantis: A Versatile Vision-Language-Action Model with Disentangled Visual Foresight
arXiv:2511.16175v2 Announce Type: replace-cross Abstract: Recent advances in Vision-Language-Action (VLA) models demonstrate that visual signals can effectively complement sparse action supervisions. However, letting VLA directly predict high-dimensional visual states can distribute model capacity and incur prohibitive training cost, while compressing visual states into more compact supervisory signals inevitably incurs information bottlenecks. Moreover, existing methods often suffer from poor
Mantis: A Versatile Vision-Language-Action Model with Disentangled Visual Foresight
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cs.AI, q-bio.NC updates on arXiv.org
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InnoEval: On Research Idea Evaluation as a Knowledge-Grounded, Multi-Perspective Reasoning Problem
arXiv:2602.14367v1 Announce Type: cross Abstract: The rapid evolution of Large Language Models has catalyzed a surge in scientific idea production, yet this leap has not been accompanied by a matching advance in idea evaluation. The fundamental nature of scientific evaluation needs knowledgeable grounding, collective deliberation, and multi-criteria decision-making. However, existing idea evaluation methods often suffer from narrow knowledge horizons, flattened evaluation dimensions, and the in