Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
One-Step Flow Policy: Self-Distillation for Fast Visuomotor Policies
arXiv:2603.12480v1 Announce Type: cross Abstract: Generative flow and diffusion models provide the continuous, multimodal action distributions needed for high-precision robotic policies. However, their reliance on iterative sampling introduces severe inference latency, degrading control frequency and harming performance in time-sensitive manipulation. To address this problem, we propose the One-Step Flow Policy (OFP), a from-scratch self-distillation framework for high-fidelity, single-step act
-
cs.AI, q-bio.NC updates on arXiv.org
-
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
arXiv:2602.14041v2 Announce Type: replace-cross Abstract: We present BitDance, a scalable autoregressive (AR) image generator that predicts binary visual tokens instead of codebook indices. With high-entropy binary latents, BitDance lets each token represent up to $2^{256}$ states, yielding a compact yet highly expressive discrete representation. Sampling from such a huge token space is difficult with standard classification. To resolve this, BitDance uses a binary diffusion head: instead of pr
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
-
Omics in Gastric
-
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.ABSTRACTGastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined w
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.
ABSTRACT
Gastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined with molecular assays (Co-IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt/β-catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224-254) of Gβ2, disrupting Gβγ-Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the β-catenin-destruction complex (GSK3 β-APC-Axin1), leading to β-catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the Gβ2-Dvl1 axis to activate Wnt/β-catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.
PMID:41808415 | PMC:PMC12976582 | DOI:10.1096/fj.202503587R
-
cs.AI, q-bio.NC updates on arXiv.org
-
Deconstructing Multimodal Mathematical Reasoning: Towards a Unified Perception-Alignment-Reasoning Paradigm
arXiv:2603.08291v1 Announce Type: new Abstract: Multimodal Mathematical Reasoning (MMR) has recently attracted increasing attention for its capability to solve mathematical problems that involve both textual and visual modalities. However, current models still face significant challenges in real-world visual math tasks. They often misinterpret diagrams, fail to align mathematical symbols with visual evidence, and produce inconsistent reasoning steps. Moreover, existing evaluations mainly focus
Deconstructing Multimodal Mathematical Reasoning: Towards a Unified Perception-Alignment-Reasoning Paradigm
-
cs.AI, q-bio.NC updates on arXiv.org
-
\$OneMillion-Bench: How Far are Language Agents from Human Experts?
arXiv:2603.07980v1 Announce Type: cross Abstract: As language models (LMs) evolve from chat assistants to long-horizon agents capable of multi-step reasoning and tool use, existing benchmarks remain largely confined to structured or exam-style tasks that fall short of real-world professional demands. To this end, we introduce \$OneMillion-Bench \$OneMillion-Bench, a benchmark of 400 expert-curated tasks spanning Law, Finance, Industry, Healthcare, and Natural Science, built to evaluate agents a
\$OneMillion-Bench: How Far are Language Agents from Human Experts?
-
Cell Death Discovery nature.com science feeds
-
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression-
cs.AI, q-bio.NC updates on arXiv.org
-
LifeBench: A Benchmark for Long-Horizon Multi-Source Memory
arXiv:2603.03781v1 Announce Type: new Abstract: Long-term memory is fundamental for personalized agents capable of accumulating knowledge, reasoning over user experiences, and adapting across time. However, existing memory benchmarks primarily target declarative memory, specifically semantic and episodic types, where all information is explicitly presented in dialogues. In contrast, real-world actions are also governed by non-declarative memory, including habitual and procedural types, and need
LifeBench: A Benchmark for Long-Horizon Multi-Source Memory
-
cs.AI, q-bio.NC updates on arXiv.org
-
EvoPrune: Early-Stage Visual Token Pruning for Efficient MLLMs
arXiv:2603.03681v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance in vision-language tasks, but their inference efficiency is severely limited by the exponential growth of visual tokens in complex scenarios such as high-resolution images and videos. Existing visual token pruning methods mainly operate after visual encoding, overlooking the substantial computational cost incurred during the encoding stage. To address this issue, we propose E
EvoPrune: Early-Stage Visual Token Pruning for Efficient MLLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
arXiv:2505.21668v3 Announce Type: replace Abstract: Practical guidance on training Large Language Models (LLMs) to leverage Code Interpreter across diverse tasks remains lacking. We present R1-Code-Interpreter, an extension of a text-only LLM trained via multi-turn supervised fine-tuning (SFT) and reinforcement learning (RL) to autonomously generate multiple code queries during step-by-step reasoning. Unlike prior RL + tool-use efforts focused on narrow domains such as math or retrieval, we cur
R1-Code-Interpreter: LLMs Reason with Code via Supervised and Multi-stage Reinforcement Learning
-
cs.AI, q-bio.NC updates on arXiv.org
-
Can a Small Model Learn to Look Before It Leaps? Dynamic Learning and Proactive Correction for Hallucination Detection
arXiv:2511.05854v2 Announce Type: replace Abstract: Hallucination in large language models (LLMs) remains a critical barrier to their safe deployment. For hallucination detection to be practical in real-world scenarios, the use of efficient small models is essential to ensure low latency and minimal resource consumption. However, existing methods rely on fixed verification strategies, where simply tuning small models to mimic fixed verification trajectories fails to capture the adaptability req
Can a Small Model Learn to Look Before It Leaps? Dynamic Learning and Proactive Correction for Hallucination Detection
-
cs.AI, q-bio.NC updates on arXiv.org
-
Uni-NTFM: A Unified Foundation Model for EEG Signal Representation Learning
arXiv:2509.24222v2 Announce Type: replace-cross Abstract: Current foundation models for electroencephalography (EEG) rely on architectures adapted from computer vision or natural language processing, typically treating neural signals as pixel grids or token sequences. This approach overlooks that the neural activity is activated by diverse sparse coding across a complex geometric topological cortex. Inspired by biological neural mechanisms, we propose the Unified Neural Topological Foundation M
Uni-NTFM: A Unified Foundation Model for EEG Signal Representation Learning
-
cs.AI, q-bio.NC updates on arXiv.org
-
Efficient Self-Evaluation for Diffusion Language Models via Sequence Regeneration
arXiv:2603.02760v1 Announce Type: cross Abstract: Diffusion large language models (dLLMs) have recently attracted significant attention for their ability to enhance diversity, controllability, and parallelism. However, their non-sequential, bidirectionally masked generation makes quality assessment difficult, underscoring the need for effective self-evaluation. In this work, we propose DiSE, a simple yet effective self-evaluation confidence quantification method for dLLMs. DiSE quantifies confi
Efficient Self-Evaluation for Diffusion Language Models via Sequence Regeneration
-
cs.AI, q-bio.NC updates on arXiv.org
-
Enhancing Generative Auto-bidding with Offline Reward Evaluation and Policy Search
arXiv:2509.15927v4 Announce Type: replace-cross Abstract: Auto-bidding is a critical tool for advertisers to improve advertising performance. Recent progress has demonstrated that AI-Generated Bidding (AIGB), which learns a conditional generative planner from offline data, achieves superior performance compared to typical offline reinforcement learning (RL)-based auto-bidding methods. However, existing AIGB methods still face a performance bottleneck due to their inherent inability to explore b
Enhancing Generative Auto-bidding with Offline Reward Evaluation and Policy Search
-
cs.AI, q-bio.NC updates on arXiv.org
-
Does Your Reasoning Model Implicitly Know When to Stop Thinking?
arXiv:2602.08354v2 Announce Type: replace Abstract: Recent advancements in large reasoning models (LRMs) have greatly improved their capabilities on complex reasoning tasks through Long Chains of Thought (CoTs). However, this approach often results in substantial redundancy, impairing computational efficiency and causing significant delays in real-time applications. Recent studies show that longer reasoning chains are frequently uncorrelated with correctness and can even be detrimental to accur
Does Your Reasoning Model Implicitly Know When to Stop Thinking?
-
cs.AI, q-bio.NC updates on arXiv.org
-
STCast: Adaptive Boundary Alignment for Global and Regional Weather Forecasting
arXiv:2509.25210v2 Announce Type: replace-cross Abstract: To gain finer regional forecasts, many works have explored the regional integration from the global atmosphere, e.g., by solving boundary equations in physics-based methods or cropping regions from global forecasts in data-driven methods. However, the effectiveness of these methods is often constrained by static and imprecise regional boundaries, resulting in poor generalization ability. To address this issue, we propose Spatial-Temporal
STCast: Adaptive Boundary Alignment for Global and Regional Weather Forecasting
-
cs.AI, q-bio.NC updates on arXiv.org
-
Experiential Reinforcement Learning
arXiv:2602.13949v1 Announce Type: cross Abstract: Reinforcement learning has become the central approach for language models (LMs) to learn from environmental reward or feedback. In practice, the environmental feedback is usually sparse and delayed. Learning from such signals is challenging, as LMs must implicitly infer how observed failures should translate into behavioral changes for future iterations. We introduce Experiential Reinforcement Learning (ERL), a training paradigm that embeds an
Experiential Reinforcement Learning
-
cs.AI, q-bio.NC updates on arXiv.org
-
A Deployment-Friendly Foundational Framework for Efficient Computational Pathology
arXiv:2602.14010v1 Announce Type: cross Abstract: Pathology foundation models (PFMs) have enabled robust generalization in computational pathology through large-scale datasets and expansive architectures, but their substantial computational cost, particularly for gigapixel whole slide images, limits clinical accessibility and scalability. Here, we present LitePath, a deployment-friendly foundational framework designed to mitigate model over-parameterization and patch level redundancy. LitePath
A Deployment-Friendly Foundational Framework for Efficient Computational Pathology
-
cs.AI, q-bio.NC updates on arXiv.org
-
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
arXiv:2602.14041v1 Announce Type: cross Abstract: We present BitDance, a scalable autoregressive (AR) image generator that predicts binary visual tokens instead of codebook indices. With high-entropy binary latents, BitDance lets each token represent up to $2^{256}$ states, yielding a compact yet highly expressive discrete representation. Sampling from such a huge token space is difficult with standard classification. To resolve this, BitDance uses a binary diffusion head: instead of predicting
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
-
cs.AI, q-bio.NC updates on arXiv.org
-
UniWeTok: An Unified Binary Tokenizer with Codebook Size $\mathit{2^{128}}$ for Unified Multimodal Large Language Model
arXiv:2602.14178v1 Announce Type: cross Abstract: Unified Multimodal Large Language Models (MLLMs) require a visual representation that simultaneously supports high-fidelity reconstruction, complex semantic extraction, and generative suitability. However, existing visual tokenizers typically struggle to satisfy these conflicting objectives within a single framework. In this paper, we introduce UniWeTok, a unified discrete tokenizer designed to bridge this gap using a massive binary codebook ($\
UniWeTok: An Unified Binary Tokenizer with Codebook Size $\mathit{2^{128}}$ for Unified Multimodal Large Language Model
-
cs.AI, q-bio.NC updates on arXiv.org
-
Sparse MeZO: Less Parameters for Better Performance in Zeroth-Order LLM Fine-Tuning
arXiv:2402.15751v2 Announce Type: replace-cross Abstract: While fine-tuning large language models (LLMs) for specific tasks often yields impressive results, it comes at the cost of memory inefficiency due to back-propagation in gradient-based training. Memory-efficient Zeroth-order (MeZO) optimizers, recently proposed to address this issue, only require forward passes during training, making them more memory-friendly. However, compared with exact gradients, ZO-based gradients usually exhibit an