Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Multi-Agent Guided Policy Optimization
arXiv:2507.18059v2 Announce Type: replace Abstract: Due to practical constraints such as partial observability and limited communication, Centralized Training with Decentralized Execution (CTDE) has become the dominant paradigm in cooperative Multi-Agent Reinforcement Learning (MARL). However, existing CTDE methods often underutilize centralized training or lack theoretical guarantees. We propose Multi-Agent Guided Policy Optimization (MAGPO), a novel framework that better leverages centralized
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cs.AI, q-bio.NC updates on arXiv.org
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Guided Policy Optimization under Partial Observability
arXiv:2505.15418v2 Announce Type: replace-cross Abstract: Reinforcement Learning (RL) in partially observable environments poses significant challenges due to the complexity of learning under uncertainty. While additional information, such as that available in simulations, can enhance training, effectively leveraging it remains an open problem. To address this, we introduce Guided Policy Optimization (GPO), a framework that co-trains a guider and a learner. The guider takes advantage of privile
Guided Policy Optimization under Partial Observability
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cs.AI, q-bio.NC updates on arXiv.org
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SvfEye: A Semantic-Visual Fusion Framework with Multi-Scale Visual Context for Multimodal Reasoning
arXiv:2603.00171v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) often struggle to accurately perceive fine-grained visual details, especially when targets are tiny or visually subtle. This challenge can be addressed through semantic-visual information fusion, which integrates global image context with fine-grained local evidence for multi-scale visual understanding. Recently, a paradigm termed "Thinking with Images" has emerged, enabling models to acquire high
SvfEye: A Semantic-Visual Fusion Framework with Multi-Scale Visual Context for Multimodal Reasoning
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats
Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.ABSTRACTCarbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed
Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats
Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.
ABSTRACT
Carbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed after 12 h. Exposure resulted in significant pathological lung damage, characterized by disrupted alveolar architecture, inflammatory cell infiltration, and increased serum levels of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α. Network toxicology analysis identified 51 potential targets associated with respiratory toxicity, with core targets including SRC, EGFR, PTGS2, CXCL8, CYP3A4, and NR3C1. Enriched pathways were primarily related to neuroactive ligand-receptor interaction, VEGF signaling, and arachidonic acid metabolism. Untargeted metabolomics revealed significant metabolic perturbations in pathways central to antioxidant defense and energy homeostasis, including glutathione metabolism, the tricarboxylic acid cycle, and arginine biosynthesis. Molecular docking confirmed stable in silico binding affinities between carbosulfan and the predicted core targets. Integrative analysis suggests that carbosulfan exposure is associated with respiratory damage, potentially through interconnected mechanisms involving oxidative stress, inflammation, and disruption of cell signaling and metabolic enzyme systems. However, given the acute high-dose nature of the model and the interpretative integration of multi-omics data, these findings should be considered hypothesis-generating. This study provides a novel system-level perspective on carbosulfan-induced respiratory toxicity and highlights key pathways and targets for future validation in chronic exposure models.
PMID:41828400 | PMC:PMC12984169 | DOI:10.3390/ijms27052170
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Omics In Lung
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Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats
Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.ABSTRACTCarbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed
Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats
Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.
ABSTRACT
Carbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed after 12 h. Exposure resulted in significant pathological lung damage, characterized by disrupted alveolar architecture, inflammatory cell infiltration, and increased serum levels of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α. Network toxicology analysis identified 51 potential targets associated with respiratory toxicity, with core targets including SRC, EGFR, PTGS2, CXCL8, CYP3A4, and NR3C1. Enriched pathways were primarily related to neuroactive ligand-receptor interaction, VEGF signaling, and arachidonic acid metabolism. Untargeted metabolomics revealed significant metabolic perturbations in pathways central to antioxidant defense and energy homeostasis, including glutathione metabolism, the tricarboxylic acid cycle, and arginine biosynthesis. Molecular docking confirmed stable in silico binding affinities between carbosulfan and the predicted core targets. Integrative analysis suggests that carbosulfan exposure is associated with respiratory damage, potentially through interconnected mechanisms involving oxidative stress, inflammation, and disruption of cell signaling and metabolic enzyme systems. However, given the acute high-dose nature of the model and the interpretative integration of multi-omics data, these findings should be considered hypothesis-generating. This study provides a novel system-level perspective on carbosulfan-induced respiratory toxicity and highlights key pathways and targets for future validation in chronic exposure models.
PMID:41828400 | PMC:PMC12984169 | DOI:10.3390/ijms27052170
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Cell Death Discovery nature.com science feeds
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MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism-
cs.AI, q-bio.NC updates on arXiv.org
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SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
arXiv:2603.07853v1 Announce Type: new Abstract: Research Agents enable models to gather information from the web using tools to answer user queries, requiring them to dynamically interleave internal reasoning with tool use. While such capabilities can in principle be learned via reinforcement learning with verifiable rewards (RLVR), we observe that agents often exhibit poor exploration behaviors, including premature termination and biased tool usage. As a result, RLVR alone yields limited impro
SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
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cs.AI, q-bio.NC updates on arXiv.org
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PIRA-Bench: A Transition from Reactive GUI Agents to GUI-based Proactive Intent Recommendation Agents
arXiv:2603.08013v1 Announce Type: new Abstract: Current Graphical User Interface (GUI) agents operate primarily under a reactive paradigm: a user must provide an explicit instruction for the agent to execute a task. However, an intelligent AI assistant should be proactive, which is capable of anticipating user intentions directly from continuous visual inputs, such as mobile or desktop screenshots, and offering timely recommendations without explicit user prompting. Transitioning to this proact
PIRA-Bench: A Transition from Reactive GUI Agents to GUI-based Proactive Intent Recommendation Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Thinking with Gaze: Sequential Eye-Tracking as Visual Reasoning Supervision for Medical VLMs
arXiv:2603.06697v1 Announce Type: cross Abstract: Vision--language models (VLMs) process images as visual tokens, yet their intermediate reasoning is often carried out in text, which can be suboptimal for visually grounded radiology tasks. Radiologists instead diagnose via sequential visual search; eye-tracking captures this process as time-ordered gaze trajectories that reveal how evidence is acquired over time. We use eye-gaze as supervision to guide VLM reasoning by introducing a small set o
Thinking with Gaze: Sequential Eye-Tracking as Visual Reasoning Supervision for Medical VLMs
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cs.AI, q-bio.NC updates on arXiv.org
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CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
arXiv:2603.07886v1 Announce Type: cross Abstract: Enhancing the ability of large language models (LLMs) to follow complex instructions is critical for their deployment in real-world applications. However, existing evaluation methods often oversimplify instruction complexity as a mere additive combination of atomic constraints, failing to adequately capture the high-dimensional complexity arising from the intricate interplay of content and format, logical workflow control, and real-world applica
CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
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cs.AI, q-bio.NC updates on arXiv.org
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VORL-EXPLORE: A Hybrid Learning Planning Approach to Multi-Robot Exploration in Dynamic Environments
arXiv:2603.07973v1 Announce Type: cross Abstract: Hierarchical multi-robot exploration commonly decouples frontier allocation from local navigation, which can make the system brittle in dense and dynamic environments. Because the allocator lacks direct awareness of execution difficulty, robots may cluster at bottlenecks, trigger oscillatory replanning, and generate redundant coverage. We propose VORL-EXPLORE, a hybrid learning and planning framework that addresses this limitation through execut
VORL-EXPLORE: A Hybrid Learning Planning Approach to Multi-Robot Exploration in Dynamic Environments
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cs.AI, q-bio.NC updates on arXiv.org
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Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
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cs.AI, q-bio.NC updates on arXiv.org
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To Mix or To Merge: Toward Multi-Domain Reinforcement Learning for Large Language Models
arXiv:2602.12566v2 Announce Type: replace Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) plays a key role in stimulating the explicit reasoning capability of Large Language Models (LLMs). We can achieve expert-level performance in some specific domains via RLVR, such as coding or math. When a general multi-domain expert-level model is required, we need to carefully consider the collaboration of RLVR across different domains. The current state-of-the-art models mainly employ two
To Mix or To Merge: Toward Multi-Domain Reinforcement Learning for Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Agentified Assessment of Logical Reasoning Agents
arXiv:2603.02788v2 Announce Type: replace Abstract: We present a framework for evaluating and benchmarking logical reasoning agents when assessment itself must be reproducible, auditable, and robust to execution failures. Building on agentified assessment, we use an assessor agent to issue tasks, enforce execution budgets, parse outputs, and record structured failure types, while the agent under test only needs to expose a standardized agent-to-agent interface. As a case study, we benchmark an
Agentified Assessment of Logical Reasoning Agents
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cs.AI, q-bio.NC updates on arXiv.org
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DrivingGen: A Comprehensive Benchmark for Generative Video World Models in Autonomous Driving
arXiv:2601.01528v2 Announce Type: replace-cross Abstract: Video generation models, as one form of world models, have emerged as one of the most exciting frontiers in AI, promising agents the ability to imagine the future by modeling the temporal evolution of complex scenes. In autonomous driving, this vision gives rise to driving world models: generative simulators that imagine ego and agent futures, enabling scalable simulation, safe testing of corner cases, and rich synthetic data generation.
DrivingGen: A Comprehensive Benchmark for Generative Video World Models in Autonomous Driving
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cs.AI, q-bio.NC updates on arXiv.org
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Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
arXiv:2602.13810v2 Announce Type: replace-cross Abstract: Learning expressive and efficient policy functions is a promising direction in reinforcement learning (RL). While flow-based policies have recently proven effective in modeling complex action distributions with a fast deterministic sampling process, they still face a trade-off between expressiveness and computational burden, which is typically controlled by the number of flow steps. In this work, we propose mean velocity policy (MVP), a
Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
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Cell Death Discovery nature.com science feeds
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Harnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-02999-yHarnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy
Harnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-02999-y
Harnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy-
cs.AI, q-bio.NC updates on arXiv.org
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Role-Aware Conditional Inference for Spatiotemporal Ecosystem Carbon Flux Prediction
arXiv:2603.03531v1 Announce Type: cross Abstract: Accurate prediction of terrestrial ecosystem carbon fluxes (e.g., CO$_2$, GPP, and CH$_4$) is essential for understanding the global carbon cycle and managing its impacts. However, prediction remains challenging due to strong spatiotemporal heterogeneity: ecosystem flux responses are constrained by slowly varying regime conditions, while short-term fluctuations are driven by high-frequency dynamic forcings. Most existing learning-based approache
Role-Aware Conditional Inference for Spatiotemporal Ecosystem Carbon Flux Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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Graph Negative Feedback Bias Correction Framework for Adaptive Heterophily Modeling
arXiv:2603.03662v1 Announce Type: cross Abstract: Graph Neural Networks (GNNs) have emerged as a powerful framework for processing graph-structured data. However, conventional GNNs and their variants are inherently limited by the homophily assumption, leading to degradation in performance on heterophilic graphs. Although substantial efforts have been made to mitigate this issue, they remain constrained by the message-passing paradigm, which is inherently rooted in homophily. In this paper, a de
Graph Negative Feedback Bias Correction Framework for Adaptive Heterophily Modeling
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cs.AI, q-bio.NC updates on arXiv.org
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Dual-Modality Multi-Stage Adversarial Safety Training: Robustifying Multimodal Web Agents Against Cross-Modal Attacks
arXiv:2603.04364v1 Announce Type: cross Abstract: Multimodal web agents that process both screenshots and accessibility trees are increasingly deployed to interact with web interfaces, yet their dual-stream architecture opens an underexplored attack surface: an adversary who injects content into the webpage DOM simultaneously corrupts both observation channels with a consistent deceptive narrative. Our vulnerability analysis on MiniWob++ reveals that attacks including a visual component far out