arXiv:2603.07940v1 Announce Type: cross Abstract: Modern science is reaching a critical inflection point. Instruments across disciplines, from particle physics and astronomy to genomics and climate modeling, now produce data of such scale, diversity, and interdependence that traditional analytical methods can no longer keep pace. This growing imbalance between data generation and data understanding signals the need for a new scientific paradigm. We propose that intelligent, human-supervised AI agents operating over deep-learning algorithms, represent the next evolution of the scientific method. Built upon large language models and multimodal learning, these agents can interpret scientific intent, design and execute analytical workflows, and ensure traceability through domain-specific languages that preserve human oversight and accountability. Particle physics, a historic incubator of computational innovation, offers the ideal testbed for this transition. At the Institute of High Energy Physics of the Chinese Academy of Sciences, the Dr. Sai system embodies this vision, a multi-agent reasoning framework deployed within collider research at the CEPC. This emerging approach does not replace human scientists but extends their cognitive reach, enabling discovery to scale with complexity and redefining how knowledge itself is produced in the age of intelligent machines. The significance of this paradigm transcends particle physics, offering a blueprint for all data-driven sciences facing the same complexity ceiling.

Nature Cancer, Published online: 05 March 2026; doi:10.1038/s43018-026-01135-0

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

arXiv:2603.03387v1 Announce Type: cross Abstract: Clustering is a fundamental approach to understanding data patterns, wherein the intuitive Euclidean distance space is commonly adopted. However, this is not the case for implicit cluster distributions reflected by qualitative attribute values, e.g., the nominal values of attributes like symptoms, marital status, etc. This paper, therefore, discovered a tree-like distance structure to flexibly represent the local order relationship among intra-attribute qualitative values. That is, treating a value as the vertex of the tree allows to capture rich order relationships among the vertex value and the others. To obtain the trees in a clustering-friendly form, a joint learning mechanism is proposed to iteratively obtain more appropriate tree structures and clusters. It turns out that the latent distance space of the whole dataset can be well-represented by a forest consisting of the learned trees. Extensive experiments demonstrate that the joint learning adapts the forest to the clustering task to yield accurate results. Comparisons of 10 counterparts on 12 real benchmark datasets with significance tests verify the superiority of the proposed method.

arXiv:2602.19248v1 Announce Type: cross Abstract: The collection and detection of video anomaly data has long been a challenging problem due to its rare occurrence and spatio-temporal scarcity. Existing video anomaly detection (VAD) methods under perform in open-world scenarios. Key contributing factors include limited dataset diversity, and inadequate understanding of context-dependent anomalous semantics. To address these issues, i) we propose LAVIDA, an end-to-end zero-shot video anomaly detection framework. ii) LAVIDA employs an Anomaly Exposure Sampler that transforms segmented objects into pseudo-anomalies to enhance model adaptability to unseen anomaly categories. It further integrates a Multimodal Large Language Model (MLLM) to bolster semantic comprehension capabilities. Additionally, iii) we design a token compression approach based on reverse attention to handle the spatio-temporal scarcity of anomalous patterns and decrease computational cost. The training process is conducted solely on pseudo anomalies without any VAD data. Evaluations across four benchmark VAD datasets demonstrate that LAVIDA achieves SOTA performance in both frame-level and pixel-level anomaly detection under the zero-shot setting. Our code is available in https://github.com/VitaminCreed/LAVIDA.

arXiv:2602.14351v1 Announce Type: cross Abstract: Model-based reinforcement learning promises strong sample efficiency but often underperforms in practice due to compounding model error, unimodal world models that average over multi-modal dynamics, and overconfident predictions that bias learning. We introduce WIMLE, a model-based method that extends Implicit Maximum Likelihood Estimation (IMLE) to the model-based RL framework to learn stochastic, multi-modal world models without iterative sampling and to estimate predictive uncertainty via ensembles and latent sampling. During training, WIMLE weights each synthetic transition by its predicted confidence, preserving useful model rollouts while attenuating bias from uncertain predictions and enabling stable learning. Across $40$ continuous-control tasks spanning DeepMind Control, MyoSuite, and HumanoidBench, WIMLE achieves superior sample efficiency and competitive or better asymptotic performance than strong model-free and model-based baselines. Notably, on the challenging Humanoid-run task, WIMLE improves sample efficiency by over $50$\% relative to the strongest competitor, and on HumanoidBench it solves $8$ of $14$ tasks (versus $4$ for BRO and $5$ for SimbaV2). These results highlight the value of IMLE-based multi-modality and uncertainty-aware weighting for stable model-based RL.