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cs.AI, q-bio.NC updates on arXiv.org
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Hierarchical Reference Sets for Robust Unsupervised Detection of Scattered and Clustered Outliers
arXiv:2603.12847v1 Announce Type: cross Abstract: Most real-world IoT data analysis tasks, such as clustering and anomaly event detection, are unsupervised and highly susceptible to the presence of outliers. In addition to sporadic scattered outliers caused by factors such as faulty sensor readings, IoT systems often exhibit clustered outliers. These occur when multiple devices or nodes produce similar anomalous measurements, for instance, owing to localized interference, emerging security thre
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cs.AI, q-bio.NC updates on arXiv.org
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OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
arXiv:2601.15369v2 Announce Type: replace-cross Abstract: This paper presents a family of advanced vision encoder, named OpenVision 3, that learns a single, unified visual representation that can serve both image understanding and image generation. Our core architecture is simple: we feed VAE-compressed image latents to a ViT encoder and train its output to support two complementary roles. First, the encoder output is passed to the ViT-VAE decoder to reconstruct the original image, encouraging
OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
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Omics in Gastric
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FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.ABSTRACTGastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined w
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.
ABSTRACT
Gastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined with molecular assays (Co-IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt/Ξ²-catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224-254) of GΞ²2, disrupting GΞ²Ξ³-Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the Ξ²-catenin-destruction complex (GSK3 Ξ²-APC-Axin1), leading to Ξ²-catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the GΞ²2-Dvl1 axis to activate Wnt/Ξ²-catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.
PMID:41808415 | PMC:PMC12976582 | DOI:10.1096/fj.202503587R