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cs.AI, q-bio.NC updates on arXiv.org
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Re2: A Consistency-ensured Dataset for Full-stage Peer Review and Multi-turn Rebuttal Discussions
arXiv:2505.07920v2 Announce Type: replace-cross Abstract: Peer review is a critical component of scientific progress in the fields like AI, but the rapid increase in submission volume has strained the reviewing system, which inevitably leads to reviewer shortages and declines review quality. Besides the growing research popularity, another key factor in this overload is the repeated resubmission of substandard manuscripts, largely due to the lack of effective tools for authors to self-evaluate
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Omics in Hepatocellular
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HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.ABSTRACTBACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib e
HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.
ABSTRACT
BACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.
METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib efficacy was tested in cell lines, patient-derived organoids/xenografts. Tested therapy effect in an immunocompetent hydrodynamic HCC model with hepatocyte-specific Hkdc1 deletion; and analyzed a postoperative cohort (n = 40) treated with lenvatinib + PD-1.
RESULTS: HKDC1, upregulated in LR HCC, was transcriptionally activated by USF1 and promoted SMS-mediated polyamine rewiring. This impaired CD8⁺ T-cell metabolism, reversible by HKDC1 knockdown or spermidine (SPD). SPD synergized with lenvatinib, triggering autophagy and suppressing tumor growth in vitro and in vivo. High HKDC1 predicted poor response and survival in patients receiving lenvatinib + aPD-1.
CONCLUSIONS: A USF1/HKDC1/SMS axis couples polyamine metabolism to immune dysfunction and lenvatinib resistance. HKDC1 is a predictive biomarker and therapeutic node and support polyamine-axis modulation to sensitize HCC to lenvatinib plus PD-1 therapy.
PMID:41812646 | DOI:10.3350/cmh.2025.1269
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cs.AI, q-bio.NC updates on arXiv.org
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OmniVideoBench: Towards Audio-Visual Understanding Evaluation for Omni MLLMs
arXiv:2510.10689v2 Announce Type: replace Abstract: Recent advances in multimodal large language models (MLLMs) have demonstrated substantial potential in video understanding. However, existing benchmarks fail to comprehensively evaluate synergistic reasoning capabilities across audio and visual modalities, often neglecting either one of the modalities or integrating them in a logically inconsistent manner. To bridge this gap, we introduce OmniVideoBench, a large-scale and rigorously designed b
OmniVideoBench: Towards Audio-Visual Understanding Evaluation for Omni MLLMs
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cs.AI, q-bio.NC updates on arXiv.org
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Training Multimodal Large Reasoning Models Needs Better Thoughts: A Three-Stage Framework for Long Chain-of-Thought Synthesis and Selection
arXiv:2512.18956v2 Announce Type: replace Abstract: Large Reasoning Models (LRMs) have demonstrated remarkable performance on complex reasoning tasks through long Chain-of-Thought (CoT) reasoning. Extending these successes to multimodal reasoning remains challenging due to the increased complexity of integrating diverse input modalities and the scarcity of high-quality long CoT training data. Existing multimodal datasets and CoT synthesis methods still suffer from limited reasoning depth, modal