Background: Evidence-based physician-pharmacist collaborative clinics have demonstrated significant short-term benefits for patients with type 2 diabetes (T2D), but their long-term effectiveness remains unclear, especially in primary health care settings. Objective: This study aimed to explore the long-term effectiveness and cost-effectiveness of a novel, digital-driven, multifaceted physician-pharmacist collaborative model for managing patients with T2D in underresourced settings. Methods: We conducted a 12-month cluster randomized controlled trial from May 2021 to December 2022 across 6 primary health care settings in China. Guided by the theory of planned behavior, the intervention involved routine therapy from physicians along with pharmaceutical interventions from pharmacists. These were delivered through a combination of face-to-face visits and mobile health care. The intervention group received 4 face-to-face visits and biweekly remote education sessions over the 12 months. We conducted intention-to-treat analyses to estimate differences in clinical and behavior indicators between the intervention and control groups. Primary outcomes included glycosylated hemoglobin and 10-year atherosclerotic cardiovascular risk. Data were analyzed using adjusted generalized estimation equations. Results: This study included 574 patients (291 in the intervention group and 283 in the control group). Over 12 months, patients in the intervention group had significant reductions in hemoglobin A_1c (–2.57 vs –1.96, respectively; P<.001; 95% CI –1.027 to –0.238) and 10-year atherosclerotic cardiovascular risk (–1.35 vs 0.01, respectively; P<.001; 95% CI –1.690 to –0.630) compared with the control group. Substantial improvements were also observed in several secondary outcomes, including fasting blood glucose, 2-hour postprandial blood glucose, waist circumference, waist-to-hip ratio, blood pressure, triglyceride, and total cholesterol. Total diabetes-related costs decreased, and patient satisfaction improved significantly in the intervention group. There were no significant differences in BMI, high-density lipoprotein, or low-density lipoprotein. Conclusions: These findings suggest that the physician-pharmacist collaborative model could improve the long-term quality and efficiency of T2D management and reduce medical costs in underresourced areas globally. Patients with T2D, especially those with central obesity or high cardiovascular risk, may benefit more from collaborative clinics. Trial Registration: Chinese Clinical Trial Registry ChiCTR2000031839; https://www.chictr.org.cn/showproj.html?proj=51910

Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-y

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease

arXiv:2511.02860v2 Announce Type: replace-cross Abstract: The distribution and interactions of cellular organelles play a critical role in mediating cellular physiology and pathology. Large-scale electron microscopy enables visualization of organelle distribution and interactions at the tissue level with nanometer resolution, but robust and efficient computational analysis tools are lacking. Here, we present a deep learning tool for universal large-scale 2D/3D electron microscopy analysis, DeepOrganelle. This new tool enables high-throughput, cell-resolved spatiotemporal mapping and digitization of organelle distribution and interactions. When applied to spermatogenesis across 12 stages and 22 differentiation status of the germ cells, DeepOrganelle uncovered previously unrecognized, stage-dependent dynamics of mitochondria-endoplasmic reticulum contact sites within one subphase of prophase I during meiosis. It also revealed coordinated organelle redistribution in Sertoli cells towards the blood-testis barrier, digitizing the remodeling dynamics of the tissue. This study demonstrates that DeepOrganelle provides a powerful framework that captures subcellular dynamics at the whole-tissue level.

arXiv:2602.13647v1 Announce Type: cross Abstract: Retrieval-augmented generation (RAG) is increasingly applied to question-answering over long academic papers, where accurate evidence allocation under a fixed token budget is critical. Existing approaches typically flatten academic papers into unstructured chunks during preprocessing, which destroys the native hierarchical structure. This loss forces retrieval to operate in a disordered space, thereby producing fragmented contexts, misallocating tokens to non-evidential regions under finite token budgets, and increasing the reasoning burden for downstream language models. To address these issues, we propose PT-RAG, an RAG framework that treats the native hierarchical structure of academic papers as a low-entropy retrieval prior. PT-RAG first inherits the native hierarchy to construct a structure-fidelity PaperTree index, which prevents entropy increase at the source. It then designs a path-guided retrieval mechanism that aligns query semantics to relevant sections and selects high relevance root-to-leaf paths under a fixed token budget, yielding compact, coherent, and low-entropy retrieval contexts. In contrast to existing RAG approaches, PT-RAG avoids entropy increase caused by destructive preprocessing and provides a native low-entropy structural basis for subsequent retrieval. To assess this design, we introduce entropy-based structural diagnostics that quantify retrieval fragmentation and evidence allocation accuracy. On three academic question-answering benchmarks, PT-RAG achieves consistently lower section entropy and evidence alignment cross entropy than strong baselines, indicating reduced context fragmentation and more precise allocation to evidential regions. These structural advantages directly translate into higher answer quality.