❌

Normal view

Received — 14 March 2026 ⏭

Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats

✇(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Xian Ju · Di Liang · Hongyu Su · Yachun Zhang · Zhenyu Liang · Yiheng Liu · Wenqi Zhao · Dan Zhang · Zhe Chen · Keming Yun
14 March 2026 at 18:00

Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.

ABSTRACT

Carbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed after 12 h. Exposure resulted in significant pathological lung damage, characterized by disrupted alveolar architecture, inflammatory cell infiltration, and increased serum levels of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α. Network toxicology analysis identified 51 potential targets associated with respiratory toxicity, with core targets including SRC, EGFR, PTGS2, CXCL8, CYP3A4, and NR3C1. Enriched pathways were primarily related to neuroactive ligand-receptor interaction, VEGF signaling, and arachidonic acid metabolism. Untargeted metabolomics revealed significant metabolic perturbations in pathways central to antioxidant defense and energy homeostasis, including glutathione metabolism, the tricarboxylic acid cycle, and arginine biosynthesis. Molecular docking confirmed stable in silico binding affinities between carbosulfan and the predicted core targets. Integrative analysis suggests that carbosulfan exposure is associated with respiratory damage, potentially through interconnected mechanisms involving oxidative stress, inflammation, and disruption of cell signaling and metabolic enzyme systems. However, given the acute high-dose nature of the model and the interpretative integration of multi-omics data, these findings should be considered hypothesis-generating. This study provides a novel system-level perspective on carbosulfan-induced respiratory toxicity and highlights key pathways and targets for future validation in chronic exposure models.

PMID:41828400 | PMC:PMC12984169 | DOI:10.3390/ijms27052170

Integrated Network Toxicology and Metabolomics Elucidate Mechanisms of Carbosulfan-Induced Respiratory Toxicity in Rats

✇Omics In Lung
By: Xian Ju · Di Liang · Hongyu Su · Yachun Zhang · Zhenyu Liang · Yiheng Liu · Wenqi Zhao · Dan Zhang · Zhe Chen · Keming Yun
14 March 2026 at 18:00

Int J Mol Sci. 2026 Feb 25;27(5):2170. doi: 10.3390/ijms27052170.

ABSTRACT

Carbosulfan is a widely used carbamate insecticide, yet its mechanisms of respiratory toxicity remain poorly understood. This study integrated network toxicology, untargeted metabolomics, and molecular docking to systematically investigate the potential mechanisms of carbosulfan-induced respiratory toxicity in male Sprague Dawley rats. Rats were administered a single oral dose of carbosulfan (125 or 250 mg/kg) and assessed after 12 h. Exposure resulted in significant pathological lung damage, characterized by disrupted alveolar architecture, inflammatory cell infiltration, and increased serum levels of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α. Network toxicology analysis identified 51 potential targets associated with respiratory toxicity, with core targets including SRC, EGFR, PTGS2, CXCL8, CYP3A4, and NR3C1. Enriched pathways were primarily related to neuroactive ligand-receptor interaction, VEGF signaling, and arachidonic acid metabolism. Untargeted metabolomics revealed significant metabolic perturbations in pathways central to antioxidant defense and energy homeostasis, including glutathione metabolism, the tricarboxylic acid cycle, and arginine biosynthesis. Molecular docking confirmed stable in silico binding affinities between carbosulfan and the predicted core targets. Integrative analysis suggests that carbosulfan exposure is associated with respiratory damage, potentially through interconnected mechanisms involving oxidative stress, inflammation, and disruption of cell signaling and metabolic enzyme systems. However, given the acute high-dose nature of the model and the interpretative integration of multi-omics data, these findings should be considered hypothesis-generating. This study provides a novel system-level perspective on carbosulfan-induced respiratory toxicity and highlights key pathways and targets for future validation in chronic exposure models.

PMID:41828400 | PMC:PMC12984169 | DOI:10.3390/ijms27052170

A Lightweight Traffic Map for Efficient Anytime LaCAM*

✇cs.AI, q-bio.NC updates on arXiv.org
By: Bojie Shen · Yue Zhang · Zhe Chen · Daniel Harabor
10 March 2026 at 12:00
arXiv:2603.07891v1 Announce Type: new Abstract: Multi-Agent Path Finding (MAPF) aims to compute collision-free paths for multiple agents and has a wide range of practical applications. LaCAM*, an anytime configuration-based solver, currently represents the state of the art. Recent work has explored the use of guidance paths to steer LaCAM* toward configurations that avoid traffic congestion, thereby improving solution quality. However, existing approaches rely on Frank-Wolfe-style optimization that repeatedly invokes single-agent search before executing LaCAM*, resulting in substantial computational overhead for large-scale problems. Moreover, the guidance path is static and primarily beneficial for finding the first solution in LaCAM*. To address these limitations, we propose a new approach that leverages LaCAM*'s ability to construct a dynamic, lightweight traffic map during its search. Experimental results demonstrate that our method achieves higher solution quality than state-of-the-art guidance-path approaches across two MAPF variants.
Received — 11 March 2026 ⏭

From 2D Alignment to 3D Plausibility: Unifying Heterogeneous 2D Priors and Penetration-Free Diffusion for Occlusion-Robust Two-Hand Reconstruction

✇cs.AI, q-bio.NC updates on arXiv.org
By: Gaoge Han · Yongkang Cheng · Zhe Chen · Shaoli Huang · Tongliang Liu
10 March 2026 at 12:00
arXiv:2503.17788v3 Announce Type: replace-cross Abstract: Two-hand reconstruction from monocular images is hampered by complex poses and severe occlusions, which often cause interaction misalignment and two-hand penetration. We address this by decoupling the problem into 2D structural alignment and 3D spatial interaction alignment, each handled by a tailored component. For 2D alignment, we pioneer the attempt to unify heterogeneous structural priors (keypoints, segmentation, and depth) from vision foundation models as complementary structured guidance for two-hand recovery. Instead of extracting priors prediction as explicit inputs, we propose a fusion-alignment encoder that absorbs their structural knowledge implicitly, achieving foundation-level guidance without foundation-level cost. For 3D spatial alignment, we propose a two-hand penetration-free diffusion model that learns a generative mapping from interpenetrated poses to realistic, collision-free configurations. Guided by collision gradients during denoising, the model converges toward the manifold of valid two-hand interactions, preserving geometric and kinematic coherence. This generative formulation approach enables physically credible reconstructions even under occlusion or ambiguous visual input. Extensive experiments on InterHand2.6M and HIC show state-of-the-art or leading performance in interaction alignment and penetration suppression. Project: https://gaogehan.github.io/A2P/
Received — 5 March 2026 ⏭

From Narrow to Panoramic Vision: Attention-Guided Cold-Start Reshapes Multimodal Reasoning

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ruilin Luo · Chufan Shi · Yizhen Zhang · Cheng Yang · Songtao Jiang · Tongkun Guan · Ruizhe Chen · Ruihang Chu · Peng Wang · Mingkun Yang · Yujiu Yang · Junyang Lin · Zhibo Yang
5 March 2026 at 13:00
arXiv:2603.03825v1 Announce Type: cross Abstract: The cold-start initialization stage plays a pivotal role in training Multimodal Large Reasoning Models (MLRMs), yet its mechanisms remain insufficiently understood. To analyze this stage, we introduce the Visual Attention Score (VAS), an attention-based metric that quantifies how much a model attends to visual tokens. We find that reasoning performance is strongly correlated with VAS (r=0.9616): models with higher VAS achieve substantially stronger multimodal reasoning. Surprisingly, multimodal cold-start fails to elevate VAS, resulting in attention distributions close to the base model, whereas text-only cold-start leads to a clear increase. We term this counter-intuitive phenomenon Lazy Attention Localization. To validate its causal role, we design training-free interventions that directly modulate attention allocation during inference, performance gains of 1$-$2% without any retraining. Building on these insights, we further propose Attention-Guided Visual Anchoring and Reflection (AVAR), a comprehensive cold-start framework that integrates visual-anchored data synthesis, attention-guided objectives, and visual-anchored reward shaping. Applied to Qwen2.5-VL-7B, AVAR achieves an average gain of 7.0% across 7 multimodal reasoning benchmarks. Ablation studies further confirm that each component of AVAR contributes step-wise to the overall gains. The code, data, and models are available at https://github.com/lrlbbzl/Qwen-AVAR.

Spectral Surgery: Training-Free Refinement of LoRA via Gradient-Guided Singular Value Reweighting

✇cs.AI, q-bio.NC updates on arXiv.org
By: Zailong Tian · Yanzhe Chen · Zhuoheng Han · Lizi Liao
5 March 2026 at 13:00
arXiv:2603.03995v1 Announce Type: cross Abstract: Low-Rank Adaptation (LoRA) improves downstream performance by restricting task updates to a low-rank parameter subspace, yet how this limited capacity is allocated within a trained adapter remains unclear. Through a geometric and empirical study across multiple tasks and backbones, we find that trained LoRA updates often exhibit an inefficient spectrum: task effects concentrate in a small subset of singular directions, while many remaining components are neutral or detrimental, motivating post-hoc refinement within the learned subspace. We propose Spectral Surgery, a training-free refinement that decomposes a LoRA update with SVD, estimates per-component sensitivity using gradients on a small calibration set, and reweights singular values under a magnitude constraint while keeping the learned directions fixed. Across Llama-3.1-8B and Qwen3-8B on four benchmarks, Spectral Surgery yields consistent gains (up to +4.4 points on CommonsenseQA and +2.4 pass@1 on HumanEval) by adjusting only $\approx 1{,}000$ scalar coefficients. These results demonstrate that SVD-structured, low-cost parameter editing can serve as a practical route to improving trained LoRA adapters in a purely post-hoc manner.

HSSBench: Benchmarking Humanities and Social Sciences Ability for Multimodal Large Language Models

✇cs.AI, q-bio.NC updates on arXiv.org
By: Zhaolu Kang · Junhao Gong · Jiaxu Yan · Wanke Xia · Yian Wang · Ziwen Wang · Huaxuan Ding · Zhuo Cheng · Wenhao Cao · Zhiyuan Feng · Siqi He · Shannan Yan · Junzhe Chen · Xiaomin He · Chaoya Jiang · Wei Ye · Kaidong Yu · Xuelong Li
4 March 2026 at 13:00
arXiv:2506.03922v3 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) have demonstrated significant potential to advance a broad range of domains. However, current benchmarks for evaluating MLLMs primarily emphasize general knowledge and vertical step-by-step reasoning typical of STEM disciplines, while overlooking the distinct needs and potential of the Humanities and Social Sciences (HSS). Tasks in the HSS domain require more horizontal, interdisciplinary thinking and a deep integration of knowledge across related fields, which presents unique challenges for MLLMs, particularly in linking abstract concepts with corresponding visual representations. Addressing this gap, we present HSSBench, a dedicated benchmark designed to assess the capabilities of MLLMs on HSS tasks in multiple languages, including the six official languages of the United Nations. We also introduce a novel data generation pipeline tailored for HSS scenarios, in which multiple domain experts and automated agents collaborate to generate and iteratively refine each sample. HSSBench contains over 13,000 meticulously designed samples, covering six key categories. We benchmark more than 20 mainstream MLLMs on HSSBench and demonstrate that it poses significant challenges even for state-of-the-art models. We hope that this benchmark will inspire further research into enhancing the cross-disciplinary reasoning abilities of MLLMs, especially their capacity to internalize and connect knowledge across fields.
Received — 25 February 2026 ⏭

A Secure and Private Distributed Bayesian Federated Learning Design

✇cs.AI, q-bio.NC updates on arXiv.org
By: Nuocheng Yang · Sihua Wang · Zhaohui Yang · Mingzhe Chen · Changchuan Yin · Kaibin Huang
24 February 2026 at 13:00
arXiv:2602.20003v1 Announce Type: cross Abstract: Distributed Federated Learning (DFL) enables decentralized model training across large-scale systems without a central parameter server. However, DFL faces three critical challenges: privacy leakage from honest-but-curious neighbors, slow convergence due to the lack of central coordination, and vulnerability to Byzantine adversaries aiming to degrade model accuracy. To address these issues, we propose a novel DFL framework that integrates Byzantine robustness, privacy preservation, and convergence acceleration. Within this framework, each device trains a local model using a Bayesian approach and independently selects an optimal subset of neighbors for posterior exchange. We formulate this neighbor selection as an optimization problem to minimize the global loss function under security and privacy constraints. Solving this problem is challenging because devices only possess partial network information, and the complex coupling between topology, security, and convergence remains unclear. To bridge this gap, we first analytically characterize the trade-offs between dynamic connectivity, Byzantine detection, privacy levels, and convergence speed. Leveraging these insights, we develop a fully distributed Graph Neural Network (GNN)-based Reinforcement Learning (RL) algorithm. This approach enables devices to make autonomous connection decisions based on local observations. Simulation results demonstrate that our method achieves superior robustness and efficiency with significantly lower overhead compared to traditional security and privacy schemes.
Received — 17 February 2026 ⏭

BiasFreeBench: a Benchmark for Mitigating Bias in Large Language Model Responses

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xin Xu · Xunzhi He · Churan Zhi · Ruizhe Chen · Julian McAuley · Zexue He
17 February 2026 at 13:00
arXiv:2510.00232v2 Announce Type: replace-cross Abstract: Existing studies on bias mitigation methods for large language models (LLMs) use diverse baselines and metrics to evaluate debiasing performance, leading to inconsistent comparisons among them. Moreover, their evaluations are mostly based on the comparison between LLMs' probabilities of biased and unbiased contexts, which ignores the gap between such evaluations and real-world use cases where users interact with LLMs by reading model responses and expect fair and safe outputs rather than LLMs' probabilities. To enable consistent evaluation across debiasing methods and bridge this gap, we introduce BiasFreeBench, an empirical benchmark that comprehensively compares eight mainstream bias mitigation techniques (covering four prompting-based and four training-based methods) on two test scenarios (multi-choice QA and open-ended multi-turn QA) by reorganizing existing datasets into a unified query-response setting. We further introduce a response-level metric, Bias-Free Score, to measure the extent to which LLM responses are fair, safe, and anti-stereotypical. Debiasing performances are systematically compared and analyzed across key dimensions: the prompting vs. training paradigm, model size, and generalization of different training strategies to unseen bias types. We release our benchmark, aiming to establish a unified testbed for bias mitigation research.
There are no more articles
❌