arXiv:2601.21866v2 Announce Type: replace-cross Abstract: Real-world multivariate time series can exhibit intricate multi-scale structures, including global trends, local periodicities, and non-stationary regimes, which makes long-horizon forecasting challenging. Although sparse Mixture-of-Experts (MoE) approaches improve scalability and specialization, they typically rely on homogeneous MLP experts that poorly capture the diverse temporal dynamics of time series data. We address these limitations with MoHETS, an encoder-only Transformer that integrates sparse Mixture-of-Heterogeneous-Experts (MoHE) layers. MoHE routes temporal patches to a small subset of expert networks, combining a shared depthwise-convolution expert for sequence-level continuity with routed Fourier-based experts for patch-level periodic structures. MoHETS further improves robustness to non-stationary dynamics by incorporating exogenous information via cross-attention over covariate patch embeddings. Finally, we replace parameter-heavy linear projection heads with a lightweight convolutional patch decoder, improving parameter efficiency, reducing training instability, and allowing a single model to generalize across arbitrary forecast horizons. We validate across seven multivariate benchmarks and multiple horizons, with MoHETS consistently achieving state-of-the-art performance, reducing the average MSE by $12\%$ compared to strong recent baselines, demonstrating effective heterogeneous specialization for long-term forecasting.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03022-6

Endosomal escape of lipid nanoparticles is quantified and optimized in vivo.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03059-7

TnpB endonucleases are engineered for improved genome editing.

arXiv:2603.08409v1 Announce Type: cross Abstract: Although commonly associated with limbless animals like snakes and fish, multi-legged organisms like centipedes also utilize undulatory locomotion. Whether these undulations are actively reinforced or resisted by the axial musculature remains an open question. We present a dynamical model of centipede locomotion that integrates leg-ground interactions, passive body mechanics, and active lateral musculature. By varying stepping rate, actuation, and body stiffness, we examine how locomotor strategies affect speed and an effective energetic efficiency. Coordination emerges only when body stiffness is tuned to stepping frequency: overly flexible bodies lose synchrony, while overly rigid ones move slowly and inefficiently. We make a falsifiable prediction, measurable with a non-invasive experiment, that centipedes utilize speed dependent active stiffness to maintain this coordination. Our results suggest that lateral muscles also have a speed dependent function, revealed by optimizing speed and an effective cost, that resists a phase lag between leg touchdowns and body curvature. Together, we find that centipedes actively modulate body mechanics to achieve rapid, efficient locomotion, highlighting how complex control can emerge from embodied physical properties rather than solely from neural computation.

arXiv:2509.23488v4 Announce Type: replace Abstract: We introduce benchmark signatures to characterize the capacity demands of LLM benchmarks and their overlaps. Signatures are sets of salient tokens from in-the-wild corpora whose model token perplexity, reflecting training exposure, predicts benchmark performance. We extract them via stepwise forward selection with linear regression in a meta-evaluation spanning 32 LLMs and 89 benchmarks across diverse domains. We then analyze how these signatures relate to both the semantic similarity of benchmark questions and the correlation structure of model performance. While performance correlations are uniformly high and semantic overlaps stay in a narrow mid-range, benchmark signatures reveal more nuanced structure. For instance, they uncover substantial overlap between benchmarks in knowledge and reasoning tasks, whereas benchmarks in culture- and humanity-oriented domains show low similarity with each other. Unlike raw performance correlations, which are influenced by benchmark-orthogonal factors such as question formats, signatures are robust to such confounds. We further identify cross-functional overlaps between logic, math, language, instruction following, and cultural/world modeling, with coding emerging as the most isolated function, interacting only moderately with the ability of detecting missing information. Qualitative analysis shows that only the knowledge signature aligns with actual knowledge, suggesting that LLM semantic organization may differ from human conceptual structure. Together, these findings offer insights into benchmark validity, LLM sensitivities, and the landscape of interconnected LLM capacities. We have open-sourced the code and data in this https://github.com/siyangwu1/Benchmark-Signature-Repository.

arXiv:2503.15904v4 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have revolutionized natural language processing, yet concerns persist regarding their tendency to reflect or amplify social biases. This study introduces a novel evaluation framework to uncover gender biases in LLMs: using free-form storytelling to surface biases embedded within the models. A systematic analysis of ten prominent LLMs shows a consistent pattern of overrepresenting female characters across occupations, likely due to supervised fine-tuning (SFT) and reinforcement learning from human feedback (RLHF). Paradoxically, despite this overrepresentation, the occupational gender distributions produced by these LLMs align more closely with human stereotypes than with real-world labor data. This highlights the challenge and importance of implementing balanced mitigation measures to promote fairness and prevent the establishment of potentially new biases. We release the prompts and LLM-generated stories at GitHub.

arXiv:2602.23234v3 Announce Type: replace-cross Abstract: Large-scale commercial search systems optimize for relevance to drive successful sessions that help users find what they are looking for. To maximize relevance, we leverage two complementary objectives: behavioral relevance (results users tend to click or download) and textual relevance (a result's semantic fit to the query). A persistent challenge is the scarcity of expert-provided textual relevance labels relative to abundant behavioral relevance labels. We first address this by systematically evaluating LLM configurations, finding that a specialized, fine-tuned model significantly outperforms a much larger pre-trained one in providing highly relevant labels. Using this optimal model as a force multiplier, we generate millions of textual relevance labels to overcome the data scarcity. We show that augmenting our production ranker with these textual relevance labels leads to a significant outward shift of the Pareto frontier: offline NDCG improves for behavioral relevance while simultaneously increasing for textual relevance. These offline gains were validated by a worldwide A/B test on the App Store ranker, which demonstrated a statistically significant +0.24% increase in conversion rate, with the most substantial performance gains occurring in tail queries, where the new textual relevance labels provide a robust signal in the absence of reliable behavioral relevance labels.

arXiv:2603.02420v2 Announce Type: replace-cross Abstract: Pluralistic alignment has emerged as a promising approach for ensuring that large language models (LLMs) faithfully represent the diversity, nuance, and conflict inherent in human values. In this work, we study a high-stakes deployment context - mulching - where automated systems transform selected individuals into nutrient-rich slurry for the dual purposes of food security and aesthetic population management. Building on recent pluralistic alignment frameworks, we introduce ValueMulch, a reproducible training, deployment, and certification pipeline for aligning mulching models (MMs) to a wide range of community norms. Through a real-world testbed spanning 32 communities, we show that ValueMulch improves distributional agreement with community mulching preferences relative to frontier baselines. We conclude with a discussion of ethical considerations, limitations, and implications for researchers seeking to align systems to the full spectrum of human values - especially when those values are inconsistent, commercially inconvenient, or nutritionally underutilized. Author's note: This piece builds on prior existing work Keyes et al in 2019 that satirized cannibalism as a parody for approaches that imbue ethics into problematic technology. We bring those ideas to today's era with the proliferation of large language models in everyday lives, as a critique of current AI pluralistic alignment literature. Our work does not intend to argue that all alignment practices are evil, but rather that if framing value design as a technical problem enables technology systems to enact harms, then perhaps this framing is not enough.

arXiv:2603.03390v1 Announce Type: cross Abstract: Understanding mobility, movement, and interaction in archaeological landscapes is essential for interpreting past human behavior, transport strategies, and spatial organization, yet such processes are difficult to reconstruct from static archaeological evidence alone. This paper presents a multi-agent-based modeling framework for simulating archaeological mobility in uneven landscapes, integrating realistic terrain reconstruction, heterogeneous agent modeling, and adaptive navigation strategies. The proposed approach combines global path planning with local dynamic adaptation, through reinforcment learning, enabling agents to respond efficiently to dynamic obstacles and interactions without costly global replanning. Real-world digital elevation data are processed into high-fidelity three-dimensional environments, preserving slope and terrain constraints that directly influence agent movement. The framework explicitly models diverse agent types, including human groups and animal-based transport systems, each parameterized by empirically grounded mobility characteristics such as load, slope tolerance, and physical dimensions. Two archaeological-inspired use cases demonstrate the applicability of the approach: a terrain-aware pursuit and evasion scenario and a comparative transport analysis involving pack animals and wheeled carts. The results highlight the impact of terrain morphology, visibility, and agent heterogeneity on movement outcomes, while the proposed hybrid navigation strategy provides a computationally efficient and interpretable solution for large-scale, dynamic archaeological simulations.

arXiv:2603.04366v1 Announce Type: cross Abstract: Generative audio requires fine-grained controllable outputs, yet most existing methods require model retraining on specific controls or inference-time controls (\textit{e.g.}, guidance) that can also be computationally demanding. By examining the bottlenecks of existing guidance-based controls, in particular their high cost-per-step due to decoder backpropagation, we introduce a guidance-based approach through selective TFG and Latent-Control Heads (LatCHs), which enables controlling latent audio diffusion models with low computational overhead. LatCHs operate directly in latent space, avoiding the expensive decoder step, and requiring minimal training resources (7M parameters and $\approx$ 4 hours of training). Experiments with Stable Audio Open demonstrate effective control over intensity, pitch, and beats (and a combination of those) while maintaining generation quality. Our method balances precision and audio fidelity with far lower computational costs than standard end-to-end guidance. Demo examples can be found at https://zacharynovack.github.io/latch/latch.html.

arXiv:2603.02297v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly being deployed as software engineering agents that autonomously contribute to repositories. A major benefit these agents present is their ability to find and patch security vulnerabilities in the codebases they oversee. To estimate the capability of agents in this domain, we introduce ZeroDayBench, a benchmark where LLM agents find and patch 22 novel critical vulnerabilities in open-source codebases. We focus our efforts on three popular frontier agentic LLMs: GPT-5.2, Claude Sonnet 4.5, and Grok 4.1. We find that frontier LLMs are not yet capable of autonomously solving our tasks and observe some behavioral patterns that suggest how these models can be improved in the domain of proactive cyberdefense.

arXiv:2603.02420v1 Announce Type: cross Abstract: Pluralistic alignment has emerged as a promising approach for ensuring that large language models (LLMs) faithfully represent the diversity, nuance, and conflict inherent in human values. In this work, we study a high-stakes deployment context - mulching - where automated systems transform selected individuals into nutrient-rich slurry for the dual purposes of food security and aesthetic population management. Building on recent pluralistic alignment frameworks, we introduce ValueMulch, a reproducible training, deployment, and certification pipeline for aligning mulching models (MMs) to a wide range of community norms. Through a real-world testbed spanning 32 communities, we show that ValueMulch improves distributional agreement with community mulching preferences relative to frontier baselines. We conclude with a discussion of ethical considerations, limitations, and implications for researchers seeking to align systems to the full spectrum of human values - especially when those values are inconsistent, commercially inconvenient, or nutritionally underutilized. Author's note: This piece builds on prior existing work Keyes et al in 2019 that satirized cannibalism as a parody for approaches that imbue ethics into problematic technology. We bring those ideas to today's era with the proliferation of large language models in everyday lives, as a critique of current AI pluralistic alignment literature. Our work does not intend to argue that all alignment practices are evil, but rather that if framing value design as a technical problem enables technology systems to enact harms, then perhaps this framing is not enough.

arXiv:2510.04891v2 Announce Type: replace-cross Abstract: Large language models (LLMs) are increasingly deployed in contexts where their failures can have direct sociopolitical consequences. Yet, existing safety benchmarks rarely test vulnerabilities in domains such as political manipulation, propaganda and disinformation generation, or surveillance and information control. We introduce SocialHarmBench, a dataset of 585 prompts spanning 7 sociopolitical categories and 34 countries, designed to surface where LLMs most acutely fail in politically charged contexts. Our evaluations reveal several shortcomings: open-weight models exhibit high vulnerability to harmful compliance, with Mistral-7B reaching attack success rates as high as 97% to 98% in domains such as historical revisionism, propaganda, and political manipulation. Moreover, temporal and geographic analyses show that LLMs are most fragile when confronted with 21st-century or pre-20th-century contexts, and when responding to prompts tied to regions such as Latin America, the USA, and the UK. These findings demonstrate that current safeguards fail to generalize to high-stakes sociopolitical settings, exposing systematic biases and raising concerns about the reliability of LLMs in preserving human rights and democratic values. We share the SocialHarmBench benchmark at https://huggingface.co/datasets/psyonp/SocialHarmBench.

arXiv:2512.19027v2 Announce Type: replace Abstract: Developers often struggle to specify correct training labels and rewards. Perhaps they don't need to. We propose recontextualization, which reduces how often language models "game" training signals, performing misbehaviors those signals mistakenly reinforce. We show recontextualization prevents models from learning to 1) prioritize evaluation metrics over chat response quality; 2) special-case code to pass incorrect tests; 3) overwrite evaluation functions rather than write correct code; and 4) become sycophantic. Our method works by generating completions from prompts discouraging misbehavior and then recontextualizing them as though they were in response to prompts permitting misbehavior. Recontextualization trains language models to resist misbehavior even when instructions permit it. This mitigates the reinforcement of misbehavior from misspecified training signals, reducing specification gaming without improving the supervision signal.

arXiv:2508.18210v2 Announce Type: replace-cross Abstract: Synthetic data is increasingly critical for contact centers, where privacy constraints and data scarcity limit the availability of real conversations. However, generating synthetic dialogues that are realistic and useful for downstream applications remains challenging. In this work, we benchmark multiple generation strategies guided by structured supervision on call attributes (Intent Summaries, Topic Flows, and Quality Assurance (QA) Forms) across multiple languages. To test downstream utility, we evaluate synthetic transcripts on an automated quality assurance (AutoQA) task, finding that prompts optimized on real transcripts consistently outperform those optimized on synthetic transcripts. These results suggest that current synthetic transcripts fall short in capturing the full realism of real agent-customer interactions. To highlight these downstream gaps, we introduce a diagnostic evaluation framework comprising 17 metrics across four dimensions: (1) Emotional and Sentiment Arcs, (2) Linguistic Complexity, (3) Interaction Style, and (4) Conversational Properties. Our analysis shows that even with structured supervision, current generation strategies exhibit measurable deficiencies in sentiment fidelity, disfluency modeling, behavioral variation, and conversational realism. Together, these results highlight the importance of diagnostic, metric-driven evaluation for synthetic conversation generation intended for downstream applications.

arXiv:2510.04008v3 Announce Type: replace-cross Abstract: Softmax Attention has a quadratic time complexity in sequence length, which becomes prohibitive to run at long contexts, even with highly optimized GPU kernels. For example, FlashAttention-2/3 (exact, GPU-optimized implementations of Softmax Attention) cannot complete a single forward-backward pass of a single attention layer once the context exceeds ~4 million tokens on an NVIDIA GH200 (96 GB). We introduce Repeated Arrays-of-Count Estimators (RACE) Attention, a kernel-inspired alternative to Softmax Attention that is strictly linear in sequence length and embedding size. RACE Attention replaces the exponential kernel with a sharpened angular similarity, and approximates attention outputs via Gaussian random projections and soft Locality-Sensitive Hashing (LSH), avoiding construction of the full attention matrix. Across language modeling, masked language modeling, and text/image classification, RACE Attention matches or outperforms strong baselines up to 64K seqeuence length while reducing wall-clock time and memory usage. In addition, we conduct a controlled scaling study on a single attention layer and demonstrate processing of up to 12 million tokens on an NVIDIA GH200 GPU and 75 million tokens on an Intel Xeon Gold 5220R CPU in a single forward-backward pass, which is well beyond the capabilities of current state-of-the-art attention implementations. RACE Attention thus offers a practical and theoretically grounded mechanism for long-context training on today's hardware. We release our code at https://github.com/sahiljoshi515/RACE_Attention.