arXiv:2603.23406v1 Announce Type: new Abstract: While large language models simulate social behaviors, their capacity for stable stance formation and identity negotiation during complex interventions remains unclear. To overcome the limitations of static evaluations, this paper proposes a novel mixed-methods framework combining computational virtual ethnography with quantitative socio-cognitive profiling. By embedding human researchers into generative multiagent communities, controlled discursive interventions are conducted to trace the evolution of collective cognition. To rigorously measure how agents internalize and react to these specific interventions, this paper formalizes three new metrics: Innate Value Bias (IVB), Persuasion Sensitivity, and Trust-Action Decoupling (TAD). Across multiple representative models, agents exhibit endogenous stances that override preset identities, consistently demonstrating an innate progressive bias (IVB > 0). When aligned with these stances, rational persuasion successfully shifts 90% of neutral agents while maintaining high trust. In contrast, conflicting emotional provocations induce a paradoxical 40.0% TAD rate in advanced models, which hypocritically alter stances despite reporting low trust. Smaller models contrastingly maintain a 0% TAD rate, strictly requiring trust for behavioral shifts. Furthermore, guided by shared stances, agents use language interactions to actively dismantle assigned power hierarchies and reconstruct self organized community boundaries. These findings expose the fragility of static prompt engineering, providing a methodological and quantitative foundation for dynamic alignment in human-agent hybrid societies. The official code is available at: https://github.com/armihia/CMASE-Endogenous-Stances

arXiv:2603.22369v1 Announce Type: cross Abstract: Accurate prediction of synthetic lethality (SL) is important for guiding the development of cancer drugs and therapies. SL prediction faces significant challenges in the effective fusion of heterogeneous multi-source data. Existing multimodal methods often suffer from "modality laziness" due to disparate convergence speeds, which hinders the exploitation of complementary information. This is also one reason why most existing SL prediction models cannot perform well on both pan-cancer and single-cancer SL pair prediction. In this study, we propose SynLeaF, a dual-stage multimodal fusion framework for SL prediction across pan- and single-cancer contexts. The framework employs a VAE-based cross-encoder with a product of experts mechanism to fuse four omics data types (gene expression, mutation, methylation, and CNV), while simultaneously utilizing a relational graph convolutional network to capture structured gene representations from biomedical knowledge graphs. To mitigate modality laziness, SynLeaF introduces a dual-stage training mechanism employing featurelevel knowledge distillation with adaptive uni-modal teacher and ensemble strategies. In extensive experiments across eight specific cancer types and a pancancer dataset, SynLeaF achieves superior performance in 17 out of 19 scenarios. Ablation studies and gradient analyses further validate the critical contributions of the proposed fusion and distillation mechanisms to model robustness and generalization. To facilitate community use, a web server is available at https://synleaf.bioinformatics-lilab.cn.

arXiv:2603.22841v1 Announce Type: cross Abstract: Drone detection is pivotal in numerous security and counter-UAV applications. However, existing deep learning-based methods typically struggle to balance robust feature representation with computational efficiency. This challenge is particularly acute when detecting miniature drones against complex backgrounds under severe environmental interference. To address these issues, we introduce UAV-DETR, a novel framework that integrates a small-target-friendly architecture with real-time detection capabilities. Specifically, UAV-DETR features a WTConv-enhanced backbone and a Sliding Window Self-Attention (SWSA-IFI) encoder, capturing the high-frequency structural details of tiny targets while drastically reducing parameter overhead. Furthermore, we propose an Efficient Cross-Scale Feature Recalibration and Fusion Network (ECFRFN) to suppress background noise and aggregate multi-scale semantics. To further enhance accuracy, UAV-DETR incorporates a hybrid Inner-CIoU and NWD loss strategy, mitigating the extreme sensitivity of standard IoU metrics to minor positional deviations in small objects. Extensive experiments demonstrate that UAV-DETR significantly outperforms the baseline RT-DETR on our custom UAV dataset (+6.61% in mAP50:95, with a 39.8% reduction in parameters) and the public DUT-ANTI-UAV benchmark (+1.4% in Precision, +1.0% in F1-Score). These results establish UAV-DETR as a superior trade-off between efficiency and precision in counter-UAV object detection. The code is available at https://github.com/wd-sir/UAVDETR.

arXiv:2603.23342v1 Announce Type: cross Abstract: Material awareness can improve robotic navigation and interaction, particularly in conditions where cameras and LiDAR degrade. We present a lightweight mmWave radar material classification pipeline designed for ultra-low-power edge devices (TI IWRL6432), using compact range-bin intensity descriptors and a Multilayer Perceptron (MLP) for real-time inference. While the classifier reaches a macro-F1 of 94.2\% under the nominal training geometry, we observe a pronounced performance drop under realistic geometry shifts, including sensor height changes and small tilt angles. These perturbations induce systematic intensity scaling and angle-dependent radar cross section (RCS) effects, pushing features out of distribution and reducing macro-F1 to around 68.5\%. We analyze these failure modes and outline practical directions for improving robustness with normalization, geometry augmentation, and motion-aware features.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

arXiv:2603.12933v1 Announce Type: new Abstract: Large Language Model (LLM)-driven Multi-Agent Systems (MAS) have demonstrated strong capability in complex reasoning and tool use, and heterogeneous agent pools further broaden the quality--cost trade-off space. Despite these advances, real-world deployment is often constrained by high inference cost, latency, and limited transparency, which hinders scalable and efficient routing. Existing routing strategies typically rely on expensive LLM-based selectors or static policies, and offer limited controllability for semantic-aware routing under dynamic loads and mixed intents, often resulting in unstable performance and inefficient resource utilization. To address these limitations, we propose AMRO-S, an efficient and interpretable routing framework for Multi-Agent Systems (MAS). AMRO-S models MAS routing as a semantic-conditioned path selection problem, enhancing routing performance through three key mechanisms: First, it leverages a supervised fine-tuned (SFT) small language model for intent inference, providing a low-overhead semantic interface for each query; second, it decomposes routing memory into task-specific pheromone specialists, reducing cross-task interference and optimizing path selection under mixed workloads; finally, it employs a quality-gated asynchronous update mechanism to decouple inference from learning, optimizing routing without increasing latency. Extensive experiments on five public benchmarks and high-concurrency stress tests demonstrate that AMRO-S consistently improves the quality--cost trade-off over strong routing baselines, while providing traceable routing evidence through structured pheromone patterns.

arXiv:2511.21471v2 Announce Type: replace Abstract: Spatial cognition is fundamental to real-world multimodal intelligence, allowing models to effectively interact with the physical environment. While multimodal large language models (MLLMs) have made significant strides, existing benchmarks often oversimplify spatial cognition, reducing it to a single-dimensional metric, which fails to capture the hierarchical structure and interdependence of spatial abilities. To address this gap, we propose a hierarchical spatial cognition framework that decomposes spatial intelligence into five progressively complex levels from basic observation to high-level planning. Building upon this taxonomy, we construct SpatialBench, a large-scale, fine-grained benchmark covering 15 tasks aligned with these cognitive levels. To provide a unified evaluation across heterogeneous tasks, we further introduce a high-level capability-oriented metric that reliably assesses a model's overall spatial reasoning ability. Extensive experiments over massive MLLMs reveal distinct performance stratification across cognitive levels: models exhibit strong perceptual grounding yet remain limited in symbolic reasoning, causal inference, and planning. Additional human tests demonstrate that humans perform selective, goal-directed abstraction, while MLLMs tend to over-attend to surface details without coherent spatial intent. Our work establishes the first systematic framework for measuring hierarchical spatial cognition in MLLMs, laying the foundation for future spatially intelligent systems.

arXiv:2204.14133v2 Announce Type: replace-cross Abstract: Topology impacts important network performance metrics, including link utilization, throughput and latency, and is of central importance to network operators. However, due to the combinatorial nature of network topology, it is extremely difficult to obtain an optimal solution, especially since topology planning in networks also often comes with management-specific constraints. As a result, local optimization with hand-tuned heuristic methods from human experts is often adopted in practice. Yet, heuristic methods cannot cover the global topology design space while taking into account constraints, and cannot guarantee to find good solutions. In this paper, we propose a novel deep reinforcement learning (DRL) algorithm for graph searching, called DRL-GS, for network topology optimization. DRL-GS consists of three novel components, including a verifier to validate the correctness of a generated network topology, a graph neural network (GNN) to efficiently approximate topology rating, and a DRL agent to conduct a topology search. DRL-GS can efficiently search over relatively large topology space and output topology with satisfactory performance. We conduct a case study based on a real-world network scenario, and our experimental results demonstrate the superior performance of DRL-GS in terms of both efficiency and performance.

arXiv:2506.05316v4 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has become an effective approach for fine-tuning large language models (LLMs), particularly to enhance their reasoning capabilities. However, RL fine-tuning remains highly resource-intensive, and existing work has largely overlooked the problem of data efficiency. In this paper, we propose two techniques to improve data efficiency in LLM RL fine-tuning: difficulty-targeted online data selection and rollout replay. We introduce the notion of adaptive difficulty to guide online data selection, prioritizing questions of moderate difficulty that are more likely to yield informative learning signals. To estimate adaptive difficulty efficiently, we develop an attention-based framework that requires rollouts for only a small reference set of questions. The adaptive difficulty of the remaining questions is then estimated based on their similarity to this set. To further reduce rollout cost, we introduce a rollout replay mechanism inspired by experience replay in traditional RL. This technique reuses recent rollouts, lowering per-step computation while maintaining stable updates. Experiments across 6 LLM-dataset combinations show that our method reduces RL fine-tuning time by 23% to 62% while reaching the same level of performance as the original GRPO algorithm. Our code is available at https://github.com/ASTRAL-Group/data-efficient-llm-rl.