Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.

arXiv:2512.05343v2 Announce Type: replace-cross Abstract: Generative methods for 3D assets have recently achieved remarkable progress, yet providing intuitive and precise control over the object geometry remains a key challenge. Existing approaches predominantly rely on text or image prompts, which often fall short in geometric specificity: language can be ambiguous, and images are difficult to manipulate. In this work, we introduce SpaceControl, a training-free test-time method for explicit spatial control of 3D asset generation. Our approach accepts a wide range of geometric inputs, from coarse primitives to detailed meshes, and integrates seamlessly with modern generative models without requiring any additional training. A control parameter lets users trade off between geometric fidelity and output realism. Extensive quantitative evaluation and user studies demonstrate that SpaceControl outperforms both training-based and optimization-based baselines in geometric faithfulness while preserving high visual quality. Finally, we present an interactive interface for real-time superquadric editing and direct 3D asset generation, enabling seamless use in creative workflows. Project page: https://spacecontrol3d.github.io/.

arXiv:2603.07016v1 Announce Type: cross Abstract: This study examines how students integrate generative artificial intelligence (AI) into design projects through the lens of the SuperSkillsStack framework, which identifies four key human competencies for effective human-AI collaboration: Agency, Domain Knowledge, Imagination, and Taste. As generative AI increasingly transforms creative practice, design education must consider how human capabilities are cultivated alongside technological tools. Using qualitative thematic analysis, this study analyzes reflective writings from 80 student design teams participating in a human-centered design course. The findings show that students primarily used AI during the early stages of the design process, including brainstorming, information synthesis, and problem framing. However, students consistently relied on human judgment to interpret contextual information, validate AI-generated outputs, and refine design solutions. Domain knowledge derived from field observations enabled students to detect inaccuracies in AI suggestions, while taste played a critical role in evaluating and selecting meaningful ideas. The results suggest that generative AI functions primarily as a cognitive accelerator rather than a replacement for human creativity. The study highlights the importance of cultivating higher-order human capabilities to support effective human-AI collaboration in design education.

arXiv:2504.18880v4 Announce Type: replace Abstract: Accurately identifying the synthesis conditions of metal-organic frameworks (MOFs) is essential for guiding experimental design, yet remains challenging because relevant information in the literature is often scattered, inconsistent, and difficult to interpret. We present MOFh6, a large language model driven system that reads raw articles or crystal codes and converts them into standardized synthesis tables. It links related descriptions across paragraphs, unifies ligand abbreviations with full names, and outputs structured parameters ready for use. MOFh6 achieved 99% extraction accuracy, resolved 94.1% of abbreviation cases across five major publishers, and maintained a precision of 0.93 +/- 0.01. Processing a full text takes 9.6 s, locating synthesis descriptions 36 s, with 100 papers processed for USD 4.24. By replacing static database lookups with real-time extraction, MOFh6 reshapes MOF synthesis research, accelerating the conversion of literature knowledge into practical synthesis protocols and enabling scalable, data-driven materials discovery.