Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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3DCity-LLM: Empowering Multi-modality Large Language Models for 3D City-scale Perception and Understanding
arXiv:2603.23447v1 Announce Type: cross Abstract: While multi-modality large language models excel in object-centric or indoor scenarios, scaling them to 3D city-scale environments remains a formidable challenge. To bridge this gap, we propose 3DCity-LLM, a unified framework designed for 3D city-scale vision-language perception and understanding. 3DCity-LLM employs a coarse-to-fine feature encoding strategy comprising three parallel branches for target object, inter-object relationship, and glo
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Omics in Hepatocellular
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HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.ABSTRACTBACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib e
HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
Clin Mol Hepatol. 2026 Mar 11. doi: 10.3350/cmh.2025.1269. Online ahead of print.
ABSTRACT
BACKGROUND/AIMS: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade.
METHODS: We established LS/LR HCC models and employed multi-omics (proteomics/RNA-seq), ChIP, luciferase, and RIP assays to map HKDC1 regulation. Tumor immunity was profiled by scRNA-seq, mIHC, and flow cytometry. SPD + lenvatinib efficacy was tested in cell lines, patient-derived organoids/xenografts. Tested therapy effect in an immunocompetent hydrodynamic HCC model with hepatocyte-specific Hkdc1 deletion; and analyzed a postoperative cohort (n = 40) treated with lenvatinib + PD-1.
RESULTS: HKDC1, upregulated in LR HCC, was transcriptionally activated by USF1 and promoted SMS-mediated polyamine rewiring. This impaired CD8⁺ T-cell metabolism, reversible by HKDC1 knockdown or spermidine (SPD). SPD synergized with lenvatinib, triggering autophagy and suppressing tumor growth in vitro and in vivo. High HKDC1 predicted poor response and survival in patients receiving lenvatinib + aPD-1.
CONCLUSIONS: A USF1/HKDC1/SMS axis couples polyamine metabolism to immune dysfunction and lenvatinib resistance. HKDC1 is a predictive biomarker and therapeutic node and support polyamine-axis modulation to sensitize HCC to lenvatinib plus PD-1 therapy.
PMID:41812646 | DOI:10.3350/cmh.2025.1269
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cs.AI, q-bio.NC updates on arXiv.org
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RoboPARA: Dual-Arm Robot Planning with Parallel Allocation and Recomposition Across Tasks
arXiv:2506.06683v4 Announce Type: replace-cross Abstract: Dual-arm robots play a crucial role in improving efficiency and flexibility in complex multitasking scenarios. While existing methods have achieved promising results in task planning, they often fail to fully optimize task parallelism, limiting the potential of dual-arm collaboration. To address this issue, we propose RoboPARA, a novel large language model (LLM)-driven framework for dual-arm task parallelism planning. RoboPARA employs a
RoboPARA: Dual-Arm Robot Planning with Parallel Allocation and Recomposition Across Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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MeanCache: From Instantaneous to Average Velocity for Accelerating Flow Matching Inference
arXiv:2601.19961v3 Announce Type: replace-cross Abstract: We present MeanCache, a training-free caching framework for efficient Flow Matching inference. Existing caching methods reduce redundant computation but typically rely on instantaneous velocity information (e.g., feature caching), which often leads to severe trajectory deviations and error accumulation under high acceleration ratios. MeanCache introduces an average-velocity perspective: by leveraging cached Jacobian--vector products (JVP
MeanCache: From Instantaneous to Average Velocity for Accelerating Flow Matching Inference
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cs.AI, q-bio.NC updates on arXiv.org
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What happens when reviewers receive AI feedback in their reviews?
arXiv:2602.13817v1 Announce Type: cross Abstract: AI is reshaping academic research, yet its role in peer review remains polarising and contentious. Advocates see its potential to reduce reviewer burden and improve quality, while critics warn of risks to fairness, accountability, and trust. At ICLR 2025, an official AI feedback tool was deployed to provide reviewers with post-review suggestions. We studied this deployment through surveys and interviews, investigating how reviewers engaged with