Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Three Creates All: You Only Sample 3 Steps
arXiv:2603.22375v1 Announce Type: cross Abstract: Diffusion models deliver high-fidelity generation but remain slow at inference time due to many sequential network evaluations. We find that standard timestep conditioning becomes a key bottleneck for few-step sampling. Motivated by layer-dependent denoising dynamics, we propose Multi-layer Time Embedding Optimization (MTEO), which freeze the pretrained diffusion backbone and distill a small set of step-wise, layer-wise time embeddings from refe
-
cs.AI, q-bio.NC updates on arXiv.org
-
From Context to Intent: Reasoning-Guided Function-Level Code Completion
arXiv:2508.09537v2 Announce Type: replace-cross Abstract: The growing capabilities of Large Language Models (LLMs) have led to their widespread adoption for function completion within code repositories. Recent studies on such tasks show promising results when explicit instructions, often in the form of docstrings, are available to guide the completion. However, in real-world scenarios, clear docstrings are frequently absent. Under such conditions, LLMs typically fail to produce accurate complet
From Context to Intent: Reasoning-Guided Function-Level Code Completion
-
Omics in Hepatocellular
-
The dual regulatory role of METTL14-mediated m<sup>6</sup>A modification in tumorigenesis and its underlying mechanisms
Front Oncol. 2026 Mar 4;16:1771313. doi: 10.3389/fonc.2026.1771313. eCollection 2026.ABSTRACTN6-methyladenosine (m6A), as the most abundant RNA epitranscriptional modification in eukaryotes, its key component of the methyltransferase complex, METTL14, not only cooperates in catalyzing m6A deposition but also has functions independent of methyltransferase activity. This article systematically reviews the dual regulatory role of METTL14 in tumors and its molecular mechanisms, mainly organizing the
The dual regulatory role of METTL14-mediated m<sup>6</sup>A modification in tumorigenesis and its underlying mechanisms
Front Oncol. 2026 Mar 4;16:1771313. doi: 10.3389/fonc.2026.1771313. eCollection 2026.
ABSTRACT
N6-methyladenosine (m6A), as the most abundant RNA epitranscriptional modification in eukaryotes, its key component of the methyltransferase complex, METTL14, not only cooperates in catalyzing m6A deposition but also has functions independent of methyltransferase activity. This article systematically reviews the dual regulatory role of METTL14 in tumors and its molecular mechanisms, mainly organizing the relevant research in a logical sequence of "tumor suppressive effect - tumor promoting effect - controversial or context-dependent". Studies have shown that METTL14 often plays a tumor suppressive role in tumors such as hepatocellular carcinoma and colorectal cancer, while in pancreatic cancer and nasopharyngeal carcinoma, it mostly promotes malignant progression, showing a high degree of context dependence. This article focuses on two key mechanisms: on the one hand, METTL14 precisely regulates the processing, stability, and function of non-coding RNAs (including miRNAs, lncRNAs, and circRNAs) through m6A modification, reshaping the competitive endogenous RNA (ceRNA) network; on the other hand, it shapes an immunosuppressive tumor microenvironment by directly upregulating immune checkpoints such as PD-L1, mediating metabolism-immune interactions, and regulating the function of immune cells. Its functional duality also stems from the selective regulation of key pathways such as PI3K/AKT, as well as the differential interpretation by different m6A readers (such as YTHDF2 and IGF2BPs). Given the close association of these mechanisms with clinical prognosis, the expression level of METTL14 shows significant potential as a prognostic marker and therapeutic target; in the future, it is necessary to combine single-cell multi-omics and other technologies to analyze its dynamic regulatory network in specific tumor contexts and explore precise treatment strategies based on synthetic lethality or targeting downstream effector molecules.
PMID:41858346 | PMC:PMC12995618 | DOI:10.3389/fonc.2026.1771313
-
Omics in Hepatocellular
-
Multi-omics analysis and experimental validation uncovers prognosis significance of IKBIP in patients with hepatocellular carcinoma: a multicenter cohort study
BMC Gastroenterol. 2026 Mar 19. doi: 10.1186/s12876-026-04756-y. Online ahead of print.NO ABSTRACTPMID:41851828 | DOI:10.1186/s12876-026-04756-y
Multi-omics analysis and experimental validation uncovers prognosis significance of IKBIP in patients with hepatocellular carcinoma: a multicenter cohort study
BMC Gastroenterol. 2026 Mar 19. doi: 10.1186/s12876-026-04756-y. Online ahead of print.
NO ABSTRACT
PMID:41851828 | DOI:10.1186/s12876-026-04756-y
-
cs.AI, q-bio.NC updates on arXiv.org
-
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v3 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
-
cs.AI, q-bio.NC updates on arXiv.org
-
OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
arXiv:2601.15369v2 Announce Type: replace-cross Abstract: This paper presents a family of advanced vision encoder, named OpenVision 3, that learns a single, unified visual representation that can serve both image understanding and image generation. Our core architecture is simple: we feed VAE-compressed image latents to a ViT encoder and train its output to support two complementary roles. First, the encoder output is passed to the ViT-VAE decoder to reconstruct the original image, encouraging
OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
-
cs.AI, q-bio.NC updates on arXiv.org
-
How Long Can Unified Multimodal Models Generate Images Reliably? Taming Long-Horizon Interleaved Image Generation via Context Curation
arXiv:2603.07540v1 Announce Type: cross Abstract: Unified multimodal models hold the promise of generating extensive, interleaved narratives, weaving text and imagery into coherent long-form stories. However, current systems suffer from a critical reliability gap: as sequences grow, generation quality rapidly collapses. In this work, we investigate the mechanism behind this failure and argue that it is distinct from standard long-context challenges. We reveal that in generation, accumulated vis
How Long Can Unified Multimodal Models Generate Images Reliably? Taming Long-Horizon Interleaved Image Generation via Context Curation
-
cs.AI, q-bio.NC updates on arXiv.org
-
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v2 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
-
cs.AI, q-bio.NC updates on arXiv.org
-
Adaptive Multi-Agent Reasoning for Text-to-Video Retrieval
arXiv:2602.19040v1 Announce Type: cross Abstract: The rise of short-form video platforms and the emergence of multimodal large language models (MLLMs) have amplified the need for scalable, effective, zero-shot text-to-video retrieval systems. While recent advances in large-scale pretraining have improved zero-shot cross-modal alignment, existing methods still struggle with query-dependent temporal reasoning, limiting their effectiveness on complex queries involving temporal, logical, or causal
Adaptive Multi-Agent Reasoning for Text-to-Video Retrieval
-
cs.AI, q-bio.NC updates on arXiv.org
-
AI-driven Large-scale Electron Microscopy enables Whole-tissue Subcellular Digitization
arXiv:2511.02860v2 Announce Type: replace-cross Abstract: The distribution and interactions of cellular organelles play a critical role in mediating cellular physiology and pathology. Large-scale electron microscopy enables visualization of organelle distribution and interactions at the tissue level with nanometer resolution, but robust and efficient computational analysis tools are lacking. Here, we present a deep learning tool for universal large-scale 2D/3D electron microscopy analysis, Deep