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cs.AI, q-bio.NC updates on arXiv.org
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CRAFT-GUI: Curriculum-Reinforced Agent For GUI Tasks
arXiv:2508.11360v2 Announce Type: replace Abstract: As autonomous agents become adept at understanding and interacting with graphical user interface (GUI) environments, a new era of automated task execution is emerging. Recent studies have demonstrated that Reinforcement Learning (RL) can effectively enhance agents' performance in dynamic interactive GUI environments. However, these methods face two key limitations: (1) they overlook the significant variation in difficulty across different GUI
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Omics in Gastric
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FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.ABSTRACTGastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined w
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.
ABSTRACT
Gastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined with molecular assays (Co-IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt/β-catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224-254) of Gβ2, disrupting Gβγ-Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the β-catenin-destruction complex (GSK3 β-APC-Axin1), leading to β-catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the Gβ2-Dvl1 axis to activate Wnt/β-catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.
PMID:41808415 | PMC:PMC12976582 | DOI:10.1096/fj.202503587R
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cs.AI, q-bio.NC updates on arXiv.org
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Prompt-SID: Learning Structural Representation Prompt via Latent Diffusion for Single-Image Denoising
arXiv:2502.06432v3 Announce Type: replace-cross Abstract: Many studies have concentrated on constructing supervised models utilizing paired datasets for image denoising, which proves to be expensive and time-consuming. Current self-supervised and unsupervised approaches typically rely on blind-spot networks or sub-image pairs sampling, resulting in pixel information loss and destruction of detailed structural information, thereby significantly constraining the efficacy of such methods. In this
Prompt-SID: Learning Structural Representation Prompt via Latent Diffusion for Single-Image Denoising
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cs.AI, q-bio.NC updates on arXiv.org
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From Narrow to Panoramic Vision: Attention-Guided Cold-Start Reshapes Multimodal Reasoning
arXiv:2603.03825v1 Announce Type: cross Abstract: The cold-start initialization stage plays a pivotal role in training Multimodal Large Reasoning Models (MLRMs), yet its mechanisms remain insufficiently understood. To analyze this stage, we introduce the Visual Attention Score (VAS), an attention-based metric that quantifies how much a model attends to visual tokens. We find that reasoning performance is strongly correlated with VAS (r=0.9616): models with higher VAS achieve substantially stron