Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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MERIT: Memory-Enhanced Retrieval for Interpretable Knowledge Tracing
arXiv:2603.22289v1 Announce Type: cross Abstract: Knowledge Tracing (KT) models students' evolving knowledge states to predict future performance, serving as a foundation for personalized education. While traditional deep learning models achieve high accuracy, they often lack interpretability. Large Language Models (LLMs) offer strong reasoning capabilities but struggle with limited context windows and hallucinations. Furthermore, existing LLM-based methods typically require expensive fine-tuni
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cs.AI, q-bio.NC updates on arXiv.org
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UniQueR: Unified Query-based Feedforward 3D Reconstruction
arXiv:2603.22851v1 Announce Type: cross Abstract: We present UniQueR, a unified query-based feedforward framework for efficient and accurate 3D reconstruction from unposed images. Existing feedforward models such as DUSt3R, VGGT, and AnySplat typically predict per-pixel point maps or pixel-aligned Gaussians, which remain fundamentally 2.5D and limited to visible surfaces. In contrast, UniQueR formulates reconstruction as a sparse 3D query inference problem. Our model learns a compact set of 3D
UniQueR: Unified Query-based Feedforward 3D Reconstruction
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cs.AI, q-bio.NC updates on arXiv.org
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Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
arXiv:2603.23064v2 Announce Type: cross Abstract: We identify a critical security vulnerability in mainstream Claw personal AI agents: untrusted content encountered during heartbeat-driven background execution can silently pollute agent memory and subsequently influence user-facing behavior without the user's awareness. This vulnerability arises from an architectural design shared across the Claw ecosystem: heartbeat background execution runs in the same session as user-facing conversation, so
Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
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cs.AI, q-bio.NC updates on arXiv.org
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Dataset Distillation-based Hybrid Federated Learning on Non-IID Data
arXiv:2409.17517v3 Announce Type: replace-cross Abstract: In federated learning, the heterogeneity of client data has a great impact on the performance of model training. Many heterogeneity issues in this process are raised by non-independently and identically distributed (non-IID) data. To address the issue of label distribution skew, we propose a hybrid federated learning framework called HFLDD, which integrates dataset distillation to generate approximately independent and equally distribute
Dataset Distillation-based Hybrid Federated Learning on Non-IID Data
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.NO ABSTRACTPMID:41870836 | DOI:10.1007/s13402-026-01194-6
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.
NO ABSTRACT
PMID:41870836 | DOI:10.1007/s13402-026-01194-6
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cs.AI, q-bio.NC updates on arXiv.org
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FastDSAC: Unlocking the Potential of Maximum Entropy RL in High-Dimensional Humanoid Control
arXiv:2603.12612v1 Announce Type: cross Abstract: Scaling Maximum Entropy Reinforcement Learning (RL) to high-dimensional humanoid control remains a formidable challenge, as the ``curse of dimensionality'' induces severe exploration inefficiency and training instability in expansive action spaces. Consequently, recent high-throughput paradigms have largely converged on deterministic policy gradients combined with massive parallel simulation. We challenge this compromise with FastDSAC, a framewo
FastDSAC: Unlocking the Potential of Maximum Entropy RL in High-Dimensional Humanoid Control
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cs.AI, q-bio.NC updates on arXiv.org
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From Text to Forecasts: Bridging Modality Gap with Temporal Evolution Semantic Space
arXiv:2603.12664v1 Announce Type: cross Abstract: Incorporating textual information into time-series forecasting holds promise for addressing event-driven non-stationarity; however, a fundamental modality gap hinders effective fusion: textual descriptions express temporal impacts implicitly and qualitatively, whereas forecasting models rely on explicit and quantitative signals. Through controlled semi-synthetic experiments, we show that existing methods over-attend to redundant tokens and strug
From Text to Forecasts: Bridging Modality Gap with Temporal Evolution Semantic Space
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Pulmonary nodule
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NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype
Am J Surg Pathol. 2026 Jun 1;50(6):695-704. doi: 10.1097/PAS.0000000000002533. Epub 2026 Mar 13.ABSTRACTWith the application of molecular techniques in pathologic diagnosis, several novel primary pulmonary epithelial tumors have been continuously discovered and classified under the WHO classification of thoracic tumors. Recently, a pulmonary tumor with NFATC2 :: NUTM2B fusion was first documented, but the spectrum of NFATC2::NUTM2 fusion variants and their associated pathologic features remains
NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype
Am J Surg Pathol. 2026 Jun 1;50(6):695-704. doi: 10.1097/PAS.0000000000002533. Epub 2026 Mar 13.
ABSTRACT
With the application of molecular techniques in pathologic diagnosis, several novel primary pulmonary epithelial tumors have been continuously discovered and classified under the WHO classification of thoracic tumors. Recently, a pulmonary tumor with NFATC2 :: NUTM2B fusion was first documented, but the spectrum of NFATC2::NUTM2 fusion variants and their associated pathologic features remains incompletely characterized. Coincidentally, we also found and described 6 primary pulmonary tumors harboring recurrent NFATC2::NUTM2A/E fusions through integrated genomic analysis. These patients, including 4 females and 2 males, with a median age of 53 years, presented with incidentally detected peripheral lung nodules composed of monotonous epithelioid cells arranged in cords, nests, and trabeculae within a prominent desmoplastic stroma. All tumors exhibited a consistent immunophenotype: CK5/6+/GATA3+/calponin+/EMA+/DOG1 (perinuclear dot-like staining)/p63-. High-throughput chromosome conformation capture (Hi-C) analysis showed the structural variation of NFATC2::NUTM2E in all 6 cases, whereas RNA sequencing detected the fusion transcripts in 5 cases ( NFATC2::NUTM2A , n=2; NFATC2::NUTM2E , n=3). Ultrastructural examination of 1 case suggested epithelial differentiation. All patients remained disease-free after complete resection (median follow-up: 24 mo; range: 9 to 41 mo). These findings define a novel primary pulmonary tumor entity driven by NFATC2::NUTM2 fusions, and characterized by a distinctive immunophenotype, expanding the spectrum of NUTM2 -associated neoplasms. Our study underscores the utility of multiomics approaches for characterizing rare neoplasms and provides a diagnostic framework for this entity.
PMID:41821426 | DOI:10.1097/PAS.0000000000002533
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Omics In Lung
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NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype
Am J Surg Pathol. 2026 Mar 13. doi: 10.1097/PAS.0000000000002533. Online ahead of print.ABSTRACTWith the application of molecular techniques in pathologic diagnosis, several novel primary pulmonary epithelial tumors have been continuously discovered and classified under the WHO classification of thoracic tumors. Recently, a pulmonary tumor with NFATC2::NUTM2B fusion was first documented, but the spectrum of NFATC2::NUTM2 fusion variants and their associated pathologic features remains incomplete
NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype
Am J Surg Pathol. 2026 Mar 13. doi: 10.1097/PAS.0000000000002533. Online ahead of print.
ABSTRACT
With the application of molecular techniques in pathologic diagnosis, several novel primary pulmonary epithelial tumors have been continuously discovered and classified under the WHO classification of thoracic tumors. Recently, a pulmonary tumor with NFATC2::NUTM2B fusion was first documented, but the spectrum of NFATC2::NUTM2 fusion variants and their associated pathologic features remains incompletely characterized. Coincidentally, we also found and described 6 primary pulmonary tumors harboring recurrent NFATC2::NUTM2A/E fusions through integrated genomic analysis. These patients, including 4 females and 2 males, with a median age of 53 years, presented with incidentally detected peripheral lung nodules composed of monotonous epithelioid cells arranged in cords, nests, and trabeculae within a prominent desmoplastic stroma. All tumors exhibited a consistent immunophenotype: CK5/6+/GATA3+/calponin+/EMA+/DOG1 (perinuclear dot-like staining)/p63-. High-throughput chromosome conformation capture (Hi-C) analysis showed the structural variation of NFATC2::NUTM2E in all 6 cases, whereas RNA sequencing detected the fusion transcripts in 5 cases (NFATC2::NUTM2A, n=2; NFATC2::NUTM2E, n=3). Ultrastructural examination of 1 case suggested epithelial differentiation. All patients remained disease-free after complete resection (median follow-up: 24 mo; range: 9 to 41 mo). These findings define a novel primary pulmonary tumor entity driven by NFATC2::NUTM2 fusions, and characterized by a distinctive immunophenotype, expanding the spectrum of NUTM2-associated neoplasms. Our study underscores the utility of multiomics approaches for characterizing rare neoplasms and provides a diagnostic framework for this entity.
PMID:41821426 | DOI:10.1097/PAS.0000000000002533
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Cell Death Discovery nature.com science feeds
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CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Cell Death Discovery, Published online: 12 March 2026; doi:10.1038/s41420-026-02995-2CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Cell Death Discovery, Published online: 12 March 2026; doi:10.1038/s41420-026-02995-2
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder-
Omics in Hepatocellular
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Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy
Genes Immun. 2026 Mar 10. doi: 10.1038/s41435-026-00382-6. Online ahead of print.ABSTRACTThe prognosis for hepatocellular carcinoma remains grim. Combining radiotherapy with immune checkpoint blockade (ICB) has shown potential to enhance therapeutic outcomes, yet there is a pressing need for further advancements. Our previous research demonstrated that this combined approach suppresses ALKBH5 gene expression and increases m6A modification levels in hepatocellular carcinoma tissues. High-throughp
Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy
Genes Immun. 2026 Mar 10. doi: 10.1038/s41435-026-00382-6. Online ahead of print.
ABSTRACT
The prognosis for hepatocellular carcinoma remains grim. Combining radiotherapy with immune checkpoint blockade (ICB) has shown potential to enhance therapeutic outcomes, yet there is a pressing need for further advancements. Our previous research demonstrated that this combined approach suppresses ALKBH5 gene expression and increases m6A modification levels in hepatocellular carcinoma tissues. High-throughput sequencing and detailed molecular analysis revealed that inhibiting ALKBH5 amplifies CIITA m6A modifications post-therapy. This modulation triggers MHC II molecule expression in tumors, facilitating the presentation of tumor-associated antigens to CD4 + T lymphocytes and the recruitment of CD8 + T cells for an anti-tumor immune response. Building on these findings, we engineered a CIITA vector with a specific site mutation to confirm that the regulation of CIITA by the combined radiotherapy and immunotherapy is mediated through m6A methylation. Consequently, we established a comprehensive network involving ALKBH5, CIITA, MHC II, and CD4+ and CD8 + T cells. To elucidate the role and underlying molecular mechanisms of this combined therapy in reshaping the tumor immune microenvironment for hepatocellular carcinoma, we employed multi-omics approaches across in vitro, animal model, and clinical multi-dimensional studies, offering novel insights for enhancing treatment efficacy.
PMID:41807814 | DOI:10.1038/s41435-026-00382-6
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cs.AI, q-bio.NC updates on arXiv.org
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SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
arXiv:2603.07853v1 Announce Type: new Abstract: Research Agents enable models to gather information from the web using tools to answer user queries, requiring them to dynamically interleave internal reasoning with tool use. While such capabilities can in principle be learned via reinforcement learning with verifiable rewards (RLVR), we observe that agents often exhibit poor exploration behaviors, including premature termination and biased tool usage. As a result, RLVR alone yields limited impro
SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
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cs.AI, q-bio.NC updates on arXiv.org
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Contextual Counterfactual Credit Assignment for Multi-Agent Reinforcement Learning in LLM Collaboration
arXiv:2603.06859v1 Announce Type: cross Abstract: Cooperative multi-agent reinforcement learning (MARL) systems powered by large language models (LLMs) are frequently optimized via sparse terminal-only feedback. This shared signal entangles upstream decisions, obstructing accurate decision-level credit assignment. To address this trajectory-level diffusion, we introduce Contextual Counterfactual Credit Assignment (\textbf{\texttt{C3}}). Instead of distributing rewards across an entire episode,
Contextual Counterfactual Credit Assignment for Multi-Agent Reinforcement Learning in LLM Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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MetaWorld-X: Hierarchical World Modeling via VLM-Orchestrated Experts for Humanoid Loco-Manipulation
arXiv:2603.08572v1 Announce Type: cross Abstract: Learning natural, stable, and compositionally generalizable whole-body control policies for humanoid robots performing simultaneous locomotion and manipulation (loco-manipulation) remains a fundamental challenge in robotics. Existing reinforcement learning approaches typically rely on a single monolithic policy to acquire multiple skills, which often leads to cross-skill gradient interference and motion pattern conflicts in high-degree-of-freedo
MetaWorld-X: Hierarchical World Modeling via VLM-Orchestrated Experts for Humanoid Loco-Manipulation
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cs.AI, q-bio.NC updates on arXiv.org
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M4Diffuser: Multi-View Diffusion Policy with Manipulability-Aware Control for Robust Mobile Manipulation
arXiv:2509.14980v2 Announce Type: replace-cross Abstract: Mobile manipulation requires the coordinated control of a mobile base and a robotic arm while simultaneously perceiving both global scene context and fine-grained object details. Existing single-view approaches often fail in unstructured environments due to limited fields of view, exploration, and generalization abilities. Moreover, classical controllers, although stable, struggle with efficiency and manipulability near singularities. To
M4Diffuser: Multi-View Diffusion Policy with Manipulability-Aware Control for Robust Mobile Manipulation
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Cell Death Discovery nature.com science feeds
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TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease
Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-yTRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease
Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-y
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease-
cs.AI, q-bio.NC updates on arXiv.org
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InEdit-Bench: Benchmarking Intermediate Logical Pathways for Intelligent Image Editing Models
arXiv:2603.03657v1 Announce Type: cross Abstract: Multimodal generative models have made significant strides in image editing, demonstrating impressive performance on a variety of static tasks. However, their proficiency typically does not extend to complex scenarios requiring dynamic reasoning, leaving them ill-equipped to model the coherent, intermediate logical pathways that constitute a multi-step evolution from an initial state to a final one. This capacity is crucial for unlocking a deepe
InEdit-Bench: Benchmarking Intermediate Logical Pathways for Intelligent Image Editing Models
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cs.AI, q-bio.NC updates on arXiv.org
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Not All Candidates are Created Equal: A Heterogeneity-Aware Approach to Pre-ranking in Recommender Systems
arXiv:2603.03770v1 Announce Type: cross Abstract: Most large-scale recommender systems follow a multi-stage cascade of retrieval, pre-ranking, ranking, and re-ranking. A key challenge at the pre-ranking stage arises from the heterogeneity of training instances sampled from coarse-grained retrieval results, fine-grained ranking signals, and exposure feedback. Our analysis reveals that prevailing pre-ranking methods, which indiscriminately mix heterogeneous samples, suffer from gradient conflicts
Not All Candidates are Created Equal: A Heterogeneity-Aware Approach to Pre-ranking in Recommender Systems
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cs.AI, q-bio.NC updates on arXiv.org
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Uni-NTFM: A Unified Foundation Model for EEG Signal Representation Learning
arXiv:2509.24222v2 Announce Type: replace-cross Abstract: Current foundation models for electroencephalography (EEG) rely on architectures adapted from computer vision or natural language processing, typically treating neural signals as pixel grids or token sequences. This approach overlooks that the neural activity is activated by diverse sparse coding across a complex geometric topological cortex. Inspired by biological neural mechanisms, we propose the Unified Neural Topological Foundation M
Uni-NTFM: A Unified Foundation Model for EEG Signal Representation Learning
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cs.AI, q-bio.NC updates on arXiv.org
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SOP-Bench: Complex Industrial SOPs for Evaluating LLM Agents
arXiv:2506.08119v2 Announce Type: replace Abstract: LLM-based agents struggle to execute complex, multi-step Standard Operating Procedures (SOPs) that are fundamental to industrial automation. Existing benchmarks fail to capture the procedural complexity and tool orchestration demands of real-world workflows. We introduce SOP-Bench, a benchmark of 2,000+ tasks from human expert-authored SOPs across 12 business domains (healthcare, logistics, finance, content moderation, etc.). Using a human-AI