Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
From Text to Forecasts: Bridging Modality Gap with Temporal Evolution Semantic Space
arXiv:2603.12664v1 Announce Type: cross Abstract: Incorporating textual information into time-series forecasting holds promise for addressing event-driven non-stationarity; however, a fundamental modality gap hinders effective fusion: textual descriptions express temporal impacts implicitly and qualitatively, whereas forecasting models rely on explicit and quantitative signals. Through controlled semi-synthetic experiments, we show that existing methods over-attend to redundant tokens and strug
-
Omics in Hepatocellular
-
Multi-omics analysis of BTF3L4 as a prognostic and immune biomarker in hepatocellular carcinoma
Transl Cancer Res. 2026 Feb 28;15(2):77. doi: 10.21037/tcr-2025-aw-2179. Epub 2026 Feb 11.ABSTRACTBACKGROUND: Hepatocellular carcinoma (HCC) exhibits notable characteristics, encompassing frequent recurrence, weak immunotherapeutic outcomes and unfavorable prognosis. BTF3L4 has been identified as a critical factor in the progression of various malignancies. However, its specific role in HCC remains to be elucidated. This investigation sought to examine BTF3L4 levels in HCC and BTF3L4's connectio
Multi-omics analysis of BTF3L4 as a prognostic and immune biomarker in hepatocellular carcinoma
Transl Cancer Res. 2026 Feb 28;15(2):77. doi: 10.21037/tcr-2025-aw-2179. Epub 2026 Feb 11.
ABSTRACT
BACKGROUND: Hepatocellular carcinoma (HCC) exhibits notable characteristics, encompassing frequent recurrence, weak immunotherapeutic outcomes and unfavorable prognosis. BTF3L4 has been identified as a critical factor in the progression of various malignancies. However, its specific role in HCC remains to be elucidated. This investigation sought to examine BTF3L4 levels in HCC and BTF3L4's connection with clinical prognosis and immune infiltration.
METHODS: We performed an extensive multi-omics evaluation in the course of our research. Bioinformatics tools were utilized to assess BTF3L4 messenger RNA (mRNA) expression in HCC. Multiplex immunohistochemistry (mIHC) was utilized to examine BTF3L4 protein expression and to explore its correlation with tumor-infiltrating immune cells (TIICs). Cox regression analysis and Kaplan-Meier survival curves were applied to determine BTF3L4's impact on patient outcomes.
RESULTS: Our analysis revealed markedly elevated levels of both BTF3L4 mRNA and protein in HCC tissues. BTF3L4 protein abundance emerged as an independent predictor of reduced survival in patients with HCC. Furthermore, elevated BTF3L4 protein expression was positively associated with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression and markedly negatively correlated with CD4+ T cells and CD66b+ neutrophils in HCC tissues.
CONCLUSIONS: This evidence indicates that BTF3L4 functions as a predictive indicator and is a potential candidate for HCC immunotherapy.
PMID:41815168 | PMC:PMC12971597 | DOI:10.21037/tcr-2025-aw-2179
-
cs.AI, q-bio.NC updates on arXiv.org
-
Agentic Critical Training
arXiv:2603.08706v1 Announce Type: new Abstract: Training large language models (LLMs) as autonomous agents often begins with imitation learning, but it only teaches agents what to do without understanding why: agents never contrast successful actions against suboptimal alternatives and thus lack awareness of action quality. Recent approaches attempt to address this by introducing self-reflection supervision derived from contrasts between expert and alternative actions. However, the training par
Agentic Critical Training
-
cs.AI, q-bio.NC updates on arXiv.org
-
A Rubric-Supervised Critic from Sparse Real-World Outcomes
arXiv:2603.03800v1 Announce Type: new Abstract: Academic benchmarks for coding agents tend to reward autonomous task completion, measured by verifiable rewards such as unit-test success. In contrast, real-world coding agents operate with humans in the loop, where success signals are typically noisy, delayed, and sparse. How can we bridge this gap? In this paper, we propose a process to learn a "critic" model from sparse and noisy interaction data, which can then be used both as a reward model f
A Rubric-Supervised Critic from Sparse Real-World Outcomes
-
cs.AI, q-bio.NC updates on arXiv.org
-
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
arXiv:2510.24702v2 Announce Type: replace-cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
-
cs.AI, q-bio.NC updates on arXiv.org
-
Robust Exploration in Directed Controller Synthesis via Reinforcement Learning with Soft Mixture-of-Experts
arXiv:2602.19244v1 Announce Type: new Abstract: On-the-fly Directed Controller Synthesis (OTF-DCS) mitigates state-space explosion by incrementally exploring the system and relies critically on an exploration policy to guide search efficiently. Recent reinforcement learning (RL) approaches learn such policies and achieve promising zero-shot generalization from small training instances to larger unseen ones. However, a fundamental limitation is anisotropic generalization, where an RL policy exhi
Robust Exploration in Directed Controller Synthesis via Reinforcement Learning with Soft Mixture-of-Experts
-
cs.AI, q-bio.NC updates on arXiv.org
-
Continuous Telemonitoring of Heart Failure using Personalised Speech Dynamics
arXiv:2602.19674v1 Announce Type: cross Abstract: Remote monitoring of heart failure (HF) via speech signals provides a non-invasive and cost-effective solution for long-term patient management. However, substantial inter-individual heterogeneity in vocal characteristics often limits the accuracy of traditional cross-sectional classification models. To address this, we propose a Longitudinal Intra-Patient Tracking (LIPT) scheme designed to capture the trajectory of relative symptomatic changes
Continuous Telemonitoring of Heart Failure using Personalised Speech Dynamics
-
cs.AI, q-bio.NC updates on arXiv.org
-
VIRTUE: Visual-Interactive Text-Image Universal Embedder
arXiv:2510.00523v2 Announce Type: replace Abstract: Multimodal representation learning models have demonstrated successful operation across complex tasks, and the integration of vision-language models (VLMs) has further enabled embedding models with instruction-following capabilities. However, existing embedding models lack visual-interactive capabilities to specify regions of interest from users (e.g., point, bounding box, mask), which have been explored in generative models to broaden their h