Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

arXiv:2603.13019v1 Announce Type: cross Abstract: Agentic reinforcement learning (RL) has emerged as a transformative workload in cloud clusters, enabling large language models (LLMs) to solve complex problems through interactions with real world. However, unlike traditional RL, agentic RL demands substantial external cloud resources, e.g., CPUs for code execution and GPUs for reward models, that exist outside the primary training cluster. Existing agentic RL framework typically rely on static over-provisioning, i.e., resources are often tied to long-lived trajectories or isolated by tasks, which leads to severe resource inefficiency. We propose the action-level orchestration, and incorporate it into ARL-Tangram, a unified resource management system that enables fine-grained external resource sharing and elasticity. ARL-Tangram utilizes a unified action-level formulation and an elastic scheduling algorithm to minimize action completion time (ACT) while satisfying heterogeneous resource constraints. Further, heterogeneous resource managers are tailored to efficiently support the action-level execution on resources with heterogeneous characteristics and topologies. Evaluation on real-world agentic RL tasks demonstrates that ARL-Tangram improves average ACT by up to 4.3$\times$, speeds up the step duration of RL training by up to 1.5$\times$, and saves the external resources by up to 71.2$\%$. This system has been deployed to support the training of the MiMo series models.

arXiv:2603.03325v1 Announce Type: cross Abstract: Large language models (LLMs) have become integral to modern Human-AI collaboration workflows, where accurately understanding user intent serves as a crucial step for generating satisfactory responses. Context-aware intent understanding, which involves inferring user intentions from situational environments, is inherently challenging because it requires reasoning over both the immediate context and the user's underlying motivations that drive their behavior. Moreover, existing approaches often treat intent understanding as a static recognition task, overlooking users' accumulated intent patterns that could provide valuable references for more accurate and generalizable understanding. To address this gap, we propose IntPro, a proxy agent that learns to adapt to individual users via retrieval-conditioned intent inference. We design intent explanations that abstract how contextual signals connect to expressed intents, and store them in an individual intent history library for retrieval. We train IntPro through supervised fine-tuning on retrieval-conditioned trajectories and multi-turn Group Relative Policy Optimization (GRPO) with tool-aware reward functions, enabling the agent to learn when to leverage historical intent patterns and when to infer directly. Experiments across three diverse scenarios (Highlight-Intent, MIntRec2.0, and Weibo Post-Sync) demonstrate that IntPro achieves strong intent understanding performance with effective context-aware reasoning capabilities across different scenarios and model types.