arXiv:2603.22767v1 Announce Type: new Abstract: Observational studies can yield clinically actionable evidence at scale, but executing them on real-world databases is open-ended and requires coherent decisions across cohort construction, analysis, and reporting. Prior evaluations of LLM agents emphasize isolated steps or single answers, missing the integrity and internal structure of the resulting evidence bundle. To address this gap, we introduce RWE-bench, a benchmark grounded in MIMIC-IV and derived from peer-reviewed observational studies. Each task provides the corresponding study protocol as the reference standard, requiring agents to execute experiments in a real database and iteratively generate tree-structured evidence bundles. We evaluate six LLMs (three open-source, three closed-source) under three agent scaffolds using both question-level correctness and end-to-end task metrics. Across 162 tasks, task success is low: the best agent reaches 39.9%, and the best open-source model reaches 30.4%. Agent scaffolds also matter substantially, causing over 30% variation in performance metrics. Furthermore, we implement an automated cohort evaluation method to rapidly localize errors and identify agent failure modes. Overall, the results highlight persistent limitations in agents' ability to produce end-to-end evidence bundles, and efficient validation remains an important direction for future work. Code and data are available at https://github.com/somewordstoolate/RWE-bench.

arXiv:2505.13180v2 Announce Type: replace Abstract: Integrating Large Language Models with symbolic planners is a promising direction for obtaining verifiable and grounded plans, with recent work extending this idea to visual domains using Vision-Language Models (VLMs). However, a rigorous comparison with methods that plan directly with VLMs is missing, due to a lack of visual benchmarks that support symbolic planning. We present ViPlan, the first open-source benchmark for comparing VLM-grounded symbolic approaches (VLM-as-grounder) with direct VLM planning methods (VLM-as-planner). ViPlan introduces a series of increasingly challenging tasks in two visual domains: a visual variant of the classic Blocksworld planning problem and a simulated household robotics environment. We find VLM-as-grounder methods to outperform direct VLM planning in Blocksworld (solving 46% of the tasks against 9%), where image grounding is both crucial and accurate. However, in the household robotics tasks, where linguistic knowledge helps, VLM-as-planner methods are greatly superior to VLM-as-grounder approaches (solving 34% of the tasks against 5%), which are hindered by partial observability. Thus, ViPlan domains capture fundamental shortcomings of both planning approaches, which we further diagnose with a qualitative failure analysis. Finally, across methods, we observe no consistent benefit from Chain-of-Thought prompting, suggesting persistent limitations in current VLMs' visual reasoning abilities.