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cs.AI, q-bio.NC updates on arXiv.org
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Memory Bear AI Memory Science Engine for Multimodal Affective Intelligence: A Technical Report
arXiv:2603.22306v1 Announce Type: new Abstract: Affective judgment in real interaction is rarely a purely local prediction problem. Emotional meaning often depends on prior trajectory, accumulated context, and multimodal evidence that may be weak, noisy, or incomplete at the current moment. Although multimodal emotion recognition (MER) has improved the integration of text, speech, and visual signals, many existing systems remain optimized for short-range inference and provide limited support fo
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cs.AI, q-bio.NC updates on arXiv.org
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Geometric Mixture-of-Experts with Curvature-Guided Adaptive Routing for Graph Representation Learning
arXiv:2603.22317v1 Announce Type: cross Abstract: Graph-structured data typically exhibits complex topological heterogeneity, making it difficult to model accurately within a single Riemannian manifold. While emerging mixed-curvature methods attempt to capture such diversity, they often rely on implicit, task-driven routing that lacks fundamental geometric grounding. To address this challenge, we propose a Geometric Mixture-of-Experts framework (GeoMoE) that adaptively fuses node representation
Geometric Mixture-of-Experts with Curvature-Guided Adaptive Routing for Graph Representation Learning
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cs.AI, q-bio.NC updates on arXiv.org
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An Accurate and Interpretable Framework for Trustworthy Process Monitoring
arXiv:2302.10426v3 Announce Type: replace Abstract: Trustworthy process monitoring seeks to build an accurate and interpretable monitoring framework, which is critical for ensuring the safety of energy conversion plant (ECP) that operates under extreme working conditions such as high pressure and temperature. Contemporary self-attentive models, however, fall short in this domain for two main reasons. First, they rely on step-wise correlations that fail to involve physically meaningful semantics
An Accurate and Interpretable Framework for Trustworthy Process Monitoring
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Omics in Hepatocellular
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Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Apr 1;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Epub 2026 Mar 23.NO ABSTRACTPMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Apr 1;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Epub 2026 Mar 23.
NO ABSTRACT
PMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Mar 23;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Online ahead of print.NO ABSTRACTPMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
Comment on "Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma"
Ecotoxicol Environ Saf. 2026 Mar 23;314:120063. doi: 10.1016/j.ecoenv.2026.120063. Online ahead of print.
NO ABSTRACT
PMID:41875554 | DOI:10.1016/j.ecoenv.2026.120063
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis
Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.ABSTRACTPURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analy
NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis
Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.
ABSTRACT
PURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.
METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Cancer Cell Line Encyclopedia (CCLE), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), CellMiner, and GeneMANIA databases, we investigated the role of NUP85 across various tumors. Correlations between NUP85 expression and pathological stage, histological grade, survival, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), drug resistance, DNA methylation, copy number variation (CNV), and single-cell expression were analyzed. Gene functional enrichment analysis was conducted to explore NUP85-associated pathways. Molecular biology experiments including Western blotting, flow cytometry, trans-well migration, and invasion assays were performed to validate NUP85's oncogenic role in lung adenocarcinoma (LUAD) and oral squamous cell carcinoma (OSCC) cell lines.
RESULTS: Our findings reveal up-regulated expression of NUP85 in most tumor tissues, with significant correlations observed with pathological stage, survival, immune infiltration, TMB, MSI, drug resistance, DNA methylation, and CNV. Molecular biology experiments confirm NUP85's tumor-promoting role in LUAD and OSCC cell lines. Single-cell sequencing data suggest elevated NUP85 expression primarily in proliferative T cells (Tprolif).
CONCLUSION: NUP85 emerges as a potential tumor marker associated with tumor immunity and poor prognosis. These insights offer avenues for the development of novel therapeutic targets and anti-neoplastic drugs.
PMID:41869435 | PMC:PMC13005628 | DOI:10.2147/ITT.S541852
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cs.AI, q-bio.NC updates on arXiv.org
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SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v3 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
arXiv:2601.15369v2 Announce Type: replace-cross Abstract: This paper presents a family of advanced vision encoder, named OpenVision 3, that learns a single, unified visual representation that can serve both image understanding and image generation. Our core architecture is simple: we feed VAE-compressed image latents to a ViT encoder and train its output to support two complementary roles. First, the encoder output is passed to the ViT-VAE decoder to reconstruct the original image, encouraging
OpenVision 3: A Family of Unified Visual Encoder for Both Understanding and Generation
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Nature Biotechnology - Issue - nature.com science feeds
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A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors
Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.
A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors
Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9
A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.-
cs.AI, q-bio.NC updates on arXiv.org
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Machine Learning for Stress Testing: Uncertainty Decomposition in Causal Panel Prediction
arXiv:2603.07438v1 Announce Type: new Abstract: Regulatory stress testing requires projecting credit losses under hypothetical macroeconomic scenarios -- a fundamentally causal question typically treated as a prediction problem. We propose a framework for policy-path counterfactual inference in panels that transparently separates what can be learned from data from what requires assumptions about confounding. Our approach has four components: (i) observational identification of path-conditional
Machine Learning for Stress Testing: Uncertainty Decomposition in Causal Panel Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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A prior information informed learning architecture for flying trajectory prediction
arXiv:2603.06863v1 Announce Type: cross Abstract: Trajectory prediction for flying objects is critical in domains ranging from sports analytics to aerospace. However, traditional methods struggle with complex physical modeling, computational inefficiencies, and high hardware demands, often neglecting critical trajectory events like landing points. This paper introduces a novel, hardware-efficient trajectory prediction framework that integrates environmental priors with a Dual-Transformer-Cascad
A prior information informed learning architecture for flying trajectory prediction
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cs.AI, q-bio.NC updates on arXiv.org
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An Embedding-based Approach to Inconsistency-tolerant Reasoning with Inconsistent Ontologies
arXiv:2304.01664v3 Announce Type: replace Abstract: Inconsistency handling is an important issue in knowledge management. Especially in ontology engineering, logical inconsistencies may occur during ontology construction. A natural way to reason with an inconsistent ontology is to utilize the maximal consistent subsets of the ontology. However, previous studies on selecting maximum consistent subsets have rarely considered the semantics of the axioms, which may result in irrational inference. I
An Embedding-based Approach to Inconsistency-tolerant Reasoning with Inconsistent Ontologies
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cs.AI, q-bio.NC updates on arXiv.org
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MAS-Orchestra: Understanding and Improving Multi-Agent Reasoning Through Holistic Orchestration and Controlled Benchmarks
arXiv:2601.14652v4 Announce Type: replace Abstract: While multi-agent systems (MAS) promise elevated intelligence through coordination of agents, current approaches to automatic MAS design under-deliver. Such shortcomings stem from two key factors: (1) methodological complexity - agent orchestration is performed using sequential, code-level execution that limits global system-level holistic reasoning and scales poorly with agent complexity - and (2) efficacy uncertainty - MAS are deployed witho
MAS-Orchestra: Understanding and Improving Multi-Agent Reasoning Through Holistic Orchestration and Controlled Benchmarks
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cs.AI, q-bio.NC updates on arXiv.org
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SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
arXiv:2602.12670v2 Announce Type: replace Abstract: Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurat
SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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A Simple "Motivation" Can Enhance Reinforcement Finetuning of Large Reasoning Models
arXiv:2506.18485v3 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards~(RLVR) has emerged as a powerful learn-to-reason paradigm for large reasoning models to tackle complex tasks. However, the current RLVR paradigm is still not efficient enough, as it works in a trial-and-error manner. To perform better, the model needs to explore the reward space by numerously generating responses and learn from fragmented reward signals, blind to the overall reward patterns.
A Simple "Motivation" Can Enhance Reinforcement Finetuning of Large Reasoning Models
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cs.AI, q-bio.NC updates on arXiv.org
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Continuous-Flow Data-Rate-Aware CNN Inference on FPGA
arXiv:2601.19940v2 Announce Type: replace-cross Abstract: Among hardware accelerators for deep-learning inference, data flow implementations offer low latency and high throughput capabilities. In these architectures, each neuron is mapped to a dedicated hardware unit, making them well-suited for field-programmable gate array (FPGA) implementation. Previous unrolled implementations mostly focus on fully connected networks because of their simplicity, although it is well known that convolutional
Continuous-Flow Data-Rate-Aware CNN Inference on FPGA
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cs.AI, q-bio.NC updates on arXiv.org
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MAGE: Meta-Reinforcement Learning for Language Agents toward Strategic Exploration and Exploitation
arXiv:2603.03680v1 Announce Type: new Abstract: Large Language Model (LLM) agents have demonstrated remarkable proficiency in learned tasks, yet they often struggle to adapt to non-stationary environments with feedback. While In-Context Learning and external memory offer some flexibility, they fail to internalize the adaptive ability required for long-term improvement. Meta-Reinforcement Learning (meta-RL) provides an alternative by embedding the learning process directly within the model. Howe
MAGE: Meta-Reinforcement Learning for Language Agents toward Strategic Exploration and Exploitation
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cs.AI, q-bio.NC updates on arXiv.org
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MedFeat: Model-Aware and Explainability-Driven Feature Engineering with LLMs for Clinical Tabular Prediction
arXiv:2603.02221v1 Announce Type: cross Abstract: In healthcare tabular predictions, classical models with feature engineering often outperform neural approaches. Recent advances in Large Language Models enable the integration of domain knowledge into feature engineering, offering a promising direction. However, existing approaches typically rely on a broad search over predefined transformations, overlooking downstream model characteristics and feature importance signals. We present MedFeat, a
MedFeat: Model-Aware and Explainability-Driven Feature Engineering with LLMs for Clinical Tabular Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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Curriculum Learning for Efficient Chain-of-Thought Distillation via Structure-Aware Masking and GRPO
arXiv:2602.17686v2 Announce Type: replace-cross Abstract: Distilling Chain-of-Thought (CoT) reasoning from large language models into compact student models presents a fundamental challenge: teacher rationales are often too verbose for smaller models to faithfully reproduce. Existing approaches either compress reasoning into single-step, losing the interpretability that makes CoT valuable. We present a three-stage curriculum learning framework that addresses this capacity mismatch through progr
Curriculum Learning for Efficient Chain-of-Thought Distillation via Structure-Aware Masking and GRPO
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cs.AI, q-bio.NC updates on arXiv.org
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Rules or Weights? Comparing User Understanding of Explainable AI Techniques with the Cognitive XAI-Adaptive Model
arXiv:2602.19620v1 Announce Type: new Abstract: Rules and Weights are popular XAI techniques for explaining AI decisions. Yet, it remains unclear how to choose between them, lacking a cognitive framework to compare their interpretability. In an elicitation user study on forward and counterfactual decision tasks, we identified 7 reasoning strategies of interpreting three XAI Schemas - weights, rules, and their hybrid. To analyze their capabilities, we propose CoXAM, a Cognitive XAI-Adaptive Mode