Normal view
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Journal of Medical Internet Research
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Suicidal Thoughts and Behaviors Among Chinese Adolescents in Relation to Negative Life Events, Internet Addiction, and Sexual Abuse: Cross-Sectional Study
Background: Increasing suicidal thoughts and behaviors (STB) among adolescents raise social concerns and have a well-recognized association with sexual abuse (SA). However, research regarding the mechanisms explaining the association between SA and STB remains limited. Objective: This study aims to examine the chained mediating effects of negative life events (NLE) and internet addiction (IA) between SA and STB among adolescents in China. Methods: This cross-sectional study used data from the Sc
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Journal of Medical Internet Research
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Improving Retrieval Augmented Generation for Health Care by Fine-Tuning Clinical Embedding Models: Development and Evaluation Study
Background: Embedding models are critical components of Retrieval Augmented Generation (RAG) systems for retrieving and searching unstructured medical data. However, existing models are predominantly trained on publicly available English datasets, limiting their effectiveness in non-English health care settings. More importantly, these models lack training on real-world clinical documents, leading to inaccurate context retrieval when integrated into RAG systems for health care applications. This
Improving Retrieval Augmented Generation for Health Care by Fine-Tuning Clinical Embedding Models: Development and Evaluation Study
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TechCrunch
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Meta is cutting several hundred jobs
Meta is laying off several hundred employees across multiple teams, including sales, recruiting, and the Reality Labs division. The cuts will impact employees in the U.S. and other international markets.
Meta is cutting several hundred jobs
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MIT Technology Review

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Why this battery company is pivoting to AI
Qichao Hu doesn’t mince words about how he sees the state of the battery industry. “Almost every Western battery company has either died or is going to die. It’s kind of the reality,” he says. Hu is the CEO of SES AI, a Massachusetts-based battery company. It once had aims of making huge amounts of advanced lithium metal batteries for major industries like electric vehicles—but now the company is placing its bets on AI materials discovery. Hu sees the pivot as an essential one. “It’s just
Why this battery company is pivoting to AI
Qichao Hu doesn’t mince words about how he sees the state of the battery industry. “Almost every Western battery company has either died or is going to die. It’s kind of the reality,” he says.
Hu is the CEO of SES AI, a Massachusetts-based battery company. It once had aims of making huge amounts of advanced lithium metal batteries for major industries like electric vehicles—but now the company is placing its bets on AI materials discovery.
Hu sees the pivot as an essential one. “It’s just not possible for a Western company to build a sustainable business,” he says. The company is still making some batteries, but only for smaller markets like drones rather than those that would require higher volumes, like EVs. The new focus is the company’s battery materials discovery platform—which it can either license to other battery companies or use to develop materials to sell.
Some leading US EV battery companies have folded in recent months, and others, like SES AI, are making dramatic changes in strategy. This shift in who’s building batteries and where they’re doing it could shape the future geopolitics of energy.
The work that would eventually evolve into SES AI began at MIT, where Hu completed his graduate research. His battery work was aimed at applications in oil and gas exploration. The industry uses sensors that go deep underground, where temperatures can top 120 °C (about 250 °F). The team hoped to develop a battery that could withstand those high temperatures and last longer on a single charge.
The chosen technology was a solid polymer lithium metal battery. These cells use lithium metal for their anode and a polymer for their electrolyte (the material that ions move through in a battery cell). Together, these components can increase the energy density of a cell significantly, relative to the lithium-ion batteries that are common in personal devices and EVs today. (Lithium-ion batteries generally use a graphite material for their anode and a liquid for the electrolyte.)
That solid-state battery technology became the foundation of Solid Energy, a startup Hu founded that spun out from MIT in 2012 and raised its first private investment in 2013.
The team eventually realized that underground oil exploration was a small market, so after several years of operation they began to focus on electric vehicles, which were starting to come into the mainstream. After the team tweaked the chemistry to work better at lower temperatures, the company built its first pilot facility in Massachusetts and eventually another facility in Shanghai.
By 2021, the battery industry was booming, Hu recalls, and EVs were the hottest industry to be in. There was a ton of interest in next-generation battery technology from major automakers at the time, and Solid Energy started developing technology with GM, Hyundai, and Honda.
Larger vehicles, like SUVs and trucks, seemed like a good fit for next-generation batteries, Hu says. Massive vehicles like the ones Americans like to drive would need lighter batteries so they could have a reasonable range without being prohibitively heavy.
The company also shifted its chemistry focus, and in 2022 it announced a battery with a silicon anode rather than a lithium metal one. That shift could help make the battery easier to manufacture.
Since then, growth in the EV market has slowed, at least in the US, partly because of major pullbacks in funding from the Trump administration. EV tax credits for drivers, a key piece of support pushing Americans toward electric options, ended in late 2025. With the market for large electric cars in trouble, Hu says, “now we have to look at every market.”
The AI materials discovery platform on which it’s pinning many of its hopes is called Molecular Universe. The company seeks not only to provide its software to other battery companies but also to identify new battery materials and either license them or sell them to those companies.

The platform has already identified six new electrolyte materials, according to the company. Hu says one is an additive that could help improve the lifetime of batteries with silicon anodes.
One of the challenges with silicon anodes is that they tend to swell a lot during use, which can cause physical damage and prevent efficient charging and discharging. To address the problem, the industry typically uses a material called fluoroethylene carbonate (FEC), which can help form an elastic film on the anode so the battery can still charge effectively. That additive can degrade at high temperatures, though, producing gases that can harm a battery’s lifetime. The SES platform identified a compound that works like FEC but doesn’t release those gases.
The company’s long history and deep battery knowledge could help make its platform a useful tool, Hu says. He sees the actual model as less crucial than SES’s domain expertise and data from years of making and testing batteries.
“By not actually making the physical battery, we’re actually able to scale and then generate revenue faster,” he says.
But some experts are skeptical about the near-term prospects for AI materials discovery to revive the industry. “New materials development, as much as we thought that was what people wanted (and, frankly, it should be what the cell makers want)—I don’t know that that seems to be the real linchpin of the battery industry’s progress,” says Kara Rodby, a technical principal at Volta Energy Technologies, a venture capital firm that focuses on the energy storage industry.
Investors are pulling back, and a slowdown in public support is making things difficult for some parts of the battery industry, she adds: “I don’t know that the ability to discover any new material is going to unlock anything new for the battery industry at this point in time.”
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TechCrunch
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Meta launches new initiative to support entrepreneurship, drive AI adoption
Meta CEO Mark Zuckerberg said in a memo to staff that small businesses have always been a big part of the company's business model, and that while tens of millions of entrepreneurs already use its platforms to grow and connect with customers, the company wants to do more in the space.
Meta launches new initiative to support entrepreneurship, drive AI adoption
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Journal of Medical Internet Research
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Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: Umbrella Review
Background: Stroke is a leading cause of long-term upper limb disability, severely impacting patients’ independence and quality of life. Robot-assisted therapy (RAT) has emerged as a promising, high-intensity rehabilitation alternative. However, conclusions from existing systematic reviews on its efficacy are inconsistent and often lack a holistic framework, limiting their use for guiding personalized clinical decisions. Objective: This study aims to systematically synthesize recent evidence on
Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: Umbrella Review
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Systems Biology and Multi-Omics in Asthma and COPD: A Systematic Review of Computational Approaches (2010-2024)
J Asthma Allergy. 2026 Mar 19;19:575312. doi: 10.2147/JAA.S575312. eCollection 2026.ABSTRACTSystems biology approaches have contributed to advancing our understanding of complex respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). This systematic review evaluates the application of systems biology methodologies in respiratory medicine, focusing on multi-omics data integration and computational techniques for biomarker discovery and mechanistic understanding. Fo
Systems Biology and Multi-Omics in Asthma and COPD: A Systematic Review of Computational Approaches (2010-2024)
J Asthma Allergy. 2026 Mar 19;19:575312. doi: 10.2147/JAA.S575312. eCollection 2026.
ABSTRACT
Systems biology approaches have contributed to advancing our understanding of complex respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). This systematic review evaluates the application of systems biology methodologies in respiratory medicine, focusing on multi-omics data integration and computational techniques for biomarker discovery and mechanistic understanding. Following PRISMA 2020 guidelines, we conducted a comprehensive literature search across Web of Science and Scopus databases, identifying 117 peer-reviewed documents published from 2010 to 2024. The review methodology employed bibliometric analysis combined with qualitative synthesis of included studies. Results demonstrate steady growth in systems biology applications for asthma and COPD research, with publication rates increasing by approximately 0.5 articles per year (R2 = 0.73, p < 0.001). Bibliometric analysis identified five major research clusters: systems biology as a foundational methodological framework (Basic Theme), COPD-focused research as the most developed area (Motor Theme), gene expression analysis, disease classification approaches, and specialized lung disease investigations (Niche Theme). Multi-omics integration studies achieved 82-91% accuracy in disease classification tasks, with transcriptomics-based asthma endotyping validated in over 1500 patients across multiple cohorts. Network analysis approaches identified hub genes (IL-6, TNF-α, MMP9) replicated across three independent studies. Machine learning applications demonstrated 80-90% accuracy for diagnostic and prognostic tasks, though external validation remains limited, with only 15% of reviewed studies including independent validation cohorts. Significant challenges persist in data integration, computational reproducibility, and clinical translation. Most studies employed modest sample sizes (median n=89), and population diversity was limited, with 89% conducted in European-ancestry populations. This review provides a comprehensive assessment of systems biology progress in respiratory medicine, identifies methodological gaps, and highlights the need for standardized protocols, larger collaborative studies, and rigorous external validation to advance clinical implementation of systems biology findings in asthma and COPD management.
PMID:41878747 | PMC:PMC13007689 | DOI:10.2147/JAA.S575312
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Omics In Lung
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Systems Biology and Multi-Omics in Asthma and COPD: A Systematic Review of Computational Approaches (2010-2024)
J Asthma Allergy. 2026 Mar 19;19:575312. doi: 10.2147/JAA.S575312. eCollection 2026.ABSTRACTSystems biology approaches have contributed to advancing our understanding of complex respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). This systematic review evaluates the application of systems biology methodologies in respiratory medicine, focusing on multi-omics data integration and computational techniques for biomarker discovery and mechanistic understanding. Fo
Systems Biology and Multi-Omics in Asthma and COPD: A Systematic Review of Computational Approaches (2010-2024)
J Asthma Allergy. 2026 Mar 19;19:575312. doi: 10.2147/JAA.S575312. eCollection 2026.
ABSTRACT
Systems biology approaches have contributed to advancing our understanding of complex respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). This systematic review evaluates the application of systems biology methodologies in respiratory medicine, focusing on multi-omics data integration and computational techniques for biomarker discovery and mechanistic understanding. Following PRISMA 2020 guidelines, we conducted a comprehensive literature search across Web of Science and Scopus databases, identifying 117 peer-reviewed documents published from 2010 to 2024. The review methodology employed bibliometric analysis combined with qualitative synthesis of included studies. Results demonstrate steady growth in systems biology applications for asthma and COPD research, with publication rates increasing by approximately 0.5 articles per year (R2 = 0.73, p < 0.001). Bibliometric analysis identified five major research clusters: systems biology as a foundational methodological framework (Basic Theme), COPD-focused research as the most developed area (Motor Theme), gene expression analysis, disease classification approaches, and specialized lung disease investigations (Niche Theme). Multi-omics integration studies achieved 82-91% accuracy in disease classification tasks, with transcriptomics-based asthma endotyping validated in over 1500 patients across multiple cohorts. Network analysis approaches identified hub genes (IL-6, TNF-α, MMP9) replicated across three independent studies. Machine learning applications demonstrated 80-90% accuracy for diagnostic and prognostic tasks, though external validation remains limited, with only 15% of reviewed studies including independent validation cohorts. Significant challenges persist in data integration, computational reproducibility, and clinical translation. Most studies employed modest sample sizes (median n=89), and population diversity was limited, with 89% conducted in European-ancestry populations. This review provides a comprehensive assessment of systems biology progress in respiratory medicine, identifies methodological gaps, and highlights the need for standardized protocols, larger collaborative studies, and rigorous external validation to advance clinical implementation of systems biology findings in asthma and COPD management.
PMID:41878747 | PMC:PMC13007689 | DOI:10.2147/JAA.S575312
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cs.AI, q-bio.NC updates on arXiv.org
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The Efficiency Attenuation Phenomenon: A Computational Challenge to the Language of Thought Hypothesis
arXiv:2603.22312v1 Announce Type: new Abstract: This paper computationally investigates whether thought requires a language-like format, as posited by the Language of Thought (LoT) hypothesis. We introduce the ``AI Private Language'' thought experiment: if two artificial agents develop an efficient, inscrutable communication protocol via multi-agent reinforcement learning (MARL), and their performance declines when forced to use a human-comprehensible language, this Efficiency Attenuation Pheno
The Efficiency Attenuation Phenomenon: A Computational Challenge to the Language of Thought Hypothesis
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cs.AI, q-bio.NC updates on arXiv.org
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Intelligence Inertia: Physical Principles and Applications
arXiv:2603.22347v1 Announce Type: new Abstract: While Landauer's principle establishes the fundamental thermodynamic floor for information erasure and Fisher Information provides a metric for local curvature in parameter space, these classical frameworks function effectively only as approximations within regimes of sparse rule-constraints. They fail to explain the super-linear, and often explosive, computational and energy costs incurred when maintaining symbolic interpretability during the rec
Intelligence Inertia: Physical Principles and Applications
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cs.AI, q-bio.NC updates on arXiv.org
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From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents
arXiv:2603.22386v1 Announce Type: new Abstract: Large language model (LLM)-based systems are becoming increasingly popular for solving tasks by constructing executable workflows that interleave LLM calls, information retrieval, tool use, code execution, memory updates, and verification. This survey reviews recent methods for designing and optimizing such workflows, which we treat as agentic computation graphs (ACGs). We organize the literature based on when workflow structure is determined, whe
From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Computational Arbitrage in AI Model Markets
arXiv:2603.22404v1 Announce Type: new Abstract: Consider a market of competing model providers selling query access to models with varying costs and capabilities. Customers submit problem instances and are willing to pay up to a budget for a verifiable solution. An arbitrageur efficiently allocates inference budget across providers to undercut the market, thus creating a competitive offering with no model-development risk. In this work, we initiate the study of arbitrage in AI model markets, em
Computational Arbitrage in AI Model Markets
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cs.AI, q-bio.NC updates on arXiv.org
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Understanding LLM Performance Degradation in Multi-Instance Processing: The Roles of Instance Count and Context Length
arXiv:2603.22608v1 Announce Type: new Abstract: Users often rely on Large Language Models (LLMs) for processing multiple documents or performing analysis over a number of instances. For example, analysing the overall sentiment of a number of movie reviews requires an LLM to process the sentiment of each review individually in order to provide a final aggregated answer. While LLM performance on such individual tasks is generally high, there has been little research on how LLMs perform when deali
Understanding LLM Performance Degradation in Multi-Instance Processing: The Roles of Instance Count and Context Length
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cs.AI, q-bio.NC updates on arXiv.org
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Bridging the Know-Act Gap via Task-Level Autoregressive Reasoning
arXiv:2603.22619v1 Announce Type: new Abstract: LLMs often generate seemingly valid answers to flawed or ill-posed inputs. This is not due to missing knowledge: under discriminative prompting, the same models can mostly identify such issues, yet fail to reflect this in standard generative responses. This reveals a fundamental know-act gap between discriminative recognition and generative behavior. Prior work largely characterizes this issue in narrow settings, such as math word problems or ques
Bridging the Know-Act Gap via Task-Level Autoregressive Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Graph-Aware Late Chunking for Retrieval-Augmented Generation in Biomedical Literature
arXiv:2603.22633v1 Announce Type: new Abstract: Retrieval-Augmented Generation (RAG) systems for biomedical literature are typically evaluated using ranking metrics like Mean Reciprocal Rank (MRR), which measure how well the system identifies the single most relevant chunk. We argue that for full-text scientific documents, this paradigm is incomplete: it rewards retrieval precision while ignoring retrieval breadth -- the ability to surface evidence from across a document's structural sections.
Graph-Aware Late Chunking for Retrieval-Augmented Generation in Biomedical Literature
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cs.AI, q-bio.NC updates on arXiv.org
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Benchmarking Multi-Agent LLM Architectures for Financial Document Processing: A Comparative Study of Orchestration Patterns, Cost-Accuracy Tradeoffs and Production Scaling Strategies
arXiv:2603.22651v1 Announce Type: new Abstract: The adoption of large language models (LLMs) for structured information extraction from financial documents has accelerated rapidly, yet production deployments face fundamental architectural decisions with limited empirical guidance. We present a systematic benchmark comparing four multi-agent orchestration architectures: sequential pipeline, parallel fan-out with merge, hierarchical supervisor-worker and reflexive self-correcting loop. These are
Benchmarking Multi-Agent LLM Architectures for Financial Document Processing: A Comparative Study of Orchestration Patterns, Cost-Accuracy Tradeoffs and Production Scaling Strategies
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cs.AI, q-bio.NC updates on arXiv.org
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Detecting outliers of pursuit eye movements: a preliminary analysis of autism spectrum disorder
arXiv:2603.22705v2 Announce Type: new Abstract: Background: Autism spectrum disorder (ASD) is characterized by significant clinical and biological heterogeneity. Conventional group-mean analyses of eye movements often mask individual atypicalities, potentially overlooking critical pathological signatures. This study aimed to identify idiosyncratic oculomotor patterns in ASD using an "outlier analysis" of smooth pursuit eye movement (SPEM). Methods: We recorded SPEM during a slow Lissajous pur
Detecting outliers of pursuit eye movements: a preliminary analysis of autism spectrum disorder
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond Binary Correctness: Scaling Evaluation of Long-Horizon Agents on Subjective Enterprise Tasks
arXiv:2603.22744v1 Announce Type: new Abstract: Large language models excel on objectively verifiable tasks such as math and programming, where evaluation reduces to unit tests or a single correct answer. In contrast, real-world enterprise work is often subjective and context-dependent: success hinges on organizational goals, user intent, and the quality of intermediate artifacts produced across long, multi-tool workflows. We introduce LH-Bench, a three-pillar evaluation design that moves bey
Beyond Binary Correctness: Scaling Evaluation of Long-Horizon Agents on Subjective Enterprise Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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AgriPestDatabase-v1.0: A Structured Insect Dataset for Training Agricultural Large Language Model
arXiv:2603.22777v1 Announce Type: new Abstract: Agricultural pest management increasingly relies on timely and accurate access to expert knowledge, yet high quality labeled data and continuous expert support remain limited, particularly for farmers operating in rural regions with unstable/no internet connectivity. At the same time, the rapid growth of AI and LLMs has created new opportunities to deliver practical decision support tools directly to end users in agriculture through compact and de
AgriPestDatabase-v1.0: A Structured Insect Dataset for Training Agricultural Large Language Model
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cs.AI, q-bio.NC updates on arXiv.org
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Reliable Classroom AI via Neuro-Symbolic Multimodal Reasoning
arXiv:2603.22793v1 Announce Type: new Abstract: Classroom AI is rapidly expanding from low-level perception toward higher-level judgments about engagement, confusion, collaboration, and instructional quality. Yet classrooms are among the hardest real-world settings for multimodal vision: they are multi-party, noisy, privacy-sensitive, pedagogically diverse, and often multilingual. In this paper, we argue that classroom AI should be treated as a critical domain, where raw predictive accuracy is