Background: Embedding models are critical components of Retrieval Augmented Generation (RAG) systems for retrieving and searching unstructured medical data. However, existing models are predominantly trained on publicly available English datasets, limiting their effectiveness in non-English health care settings. More importantly, these models lack training on real-world clinical documents, leading to inaccurate context retrieval when integrated into RAG systems for health care applications. This gap is particularly pronounced in specialized medical documentation containing domain-specific terminology, abbreviations, and nuanced clinical language. Objective: This retrospective study aimed to develop and validate embedding models specifically trained on real-world clinical documents from multiple medical specialties to improve medical information retrieval (IR) and RAG system performance in both German and English language contexts. Methods: We fine-tuned embedding models, so-called sentence transformers, using the multilingual-e5-large architecture as a foundation. Training data consisted of approximately 11 million question-answer pairs synthetically generated from 400,000 diverse clinical documents from a large German tertiary hospital, spanning 163,840 patients and 282,728 clinical cases between 2018 and 2023. The large language model generated medically relevant questions and corresponding answers for each document. The dataset was additionally pseudonymized and translated into English to aim for broader applicability. Models were evaluated in 2 distinct scenarios: IR using questions with multiple relevant passages, and RAG system performance in both cross-patient and patient-centered contexts. Results: In the IR evaluation, the fine-tuned miracle model achieved a mAP@100 of 0.27, outperforming the multilingual-e5-large baseline (0.14) and state-of-the-art models such as bge-m3 (0.11). In the RAG evaluation, the model demonstrated robust performance comparable with the baseline in the constrained patient-centered scenario (BERTScore F1 0.781 vs 0.778) and showed moderate improvements in the unconstrained cross-patient setting (BLEURT 0.56 vs 0.53). Notably, the model trained on pseudonymized data achieved comparable retrieval performance (mAP@100 0.25) and the highest scores for patient-centered contextual precision (0.93). Performance gains were robust in the German dataset, while the translated English model demonstrated promising results as a proof of concept for cross-lingual transfer. Conclusions: By leveraging a comprehensive real-world dataset spanning multiple medical specialties and using large language models for synthetic question generation, we successfully created and validated domain-specific embedding models. These models can improve medical IR in large-scale search spaces and perform competitively in constrained RAG applications. By publishing the models trained on pseudonymized data, other health care institutions can integrate or adapt these embedding models to their needs. This work establishes a reproducible framework for developing domain-specific clinical embedding models, with the potential to improve data retrieval in medical settings.

arXiv:2603.22705v2 Announce Type: new Abstract: Background: Autism spectrum disorder (ASD) is characterized by significant clinical and biological heterogeneity. Conventional group-mean analyses of eye movements often mask individual atypicalities, potentially overlooking critical pathological signatures. This study aimed to identify idiosyncratic oculomotor patterns in ASD using an "outlier analysis" of smooth pursuit eye movement (SPEM). Methods: We recorded SPEM during a slow Lissajous pursuit task in 18 adults with ASD and 39 typically developed (TD) individuals. To quantify individual deviations, we derived an "outlier score" based on the Mahalanobis distance. This score was calculated from a feature vector, optimized via Principal Component Analysis (PCA), comprising the temporal lag ($\Delta$t) and the spatial deviation ($\Delta$s). An outlier was statistically defined as a score exceeding $\sqrt{10}$ (approximately 3.16$\sigma$) relative to the TD normative distribution. Results: While the TD group exhibited a low outlier rate of 5.1%, the ASD group demonstrated a significantly higher prevalence of 38.9% (7/18) (binomial P = 0.0034). Furthermore, the mean outlier score was significantly elevated in the ASD group (3.00 $\pm$ 2.62) compared to the TD group (1.52 $\pm$ 0.80; P = 0.002). Notably, these extreme deviations were captured even when conventional mean-based comparisons showed limited sensitivity. Conclusions: Our outlier analysis successfully visualized the high degree of idiosyncratic atypicality in ASD oculomotor control. By shifting the focus from group averages to individual deviations, this approach provides a sensitive metric for capturing the inherent heterogeneity of ASD, offering a potential baseline for identifying clinical subtypes.

arXiv:2603.22871v1 Announce Type: new Abstract: Current large language models (LLMs) primarily rely on linear sequence generation and massive parameter counts, yet they severely struggle with complex algorithmic reasoning. While recent reasoning architectures, such as the Hierarchical Reasoning Model (HRM) and Tiny Recursive Model (TRM), demonstrate that compact recursive networks can tackle these tasks, their training dynamics often lack rigorous mathematical guarantees, leading to instability and representational collapse. We propose the Contraction Mapping Model (CMM), a novel architecture that reformulates discrete recursive reasoning into continuous Neural Ordinary and Stochastic Differential Equations (NODEs/NSDEs). By explicitly enforcing the convergence of the latent phase point to a stable equilibrium state and mitigating feature collapse with a hyperspherical repulsion loss, the CMM provides a mathematically grounded and highly stable reasoning engine. On the Sudoku-Extreme benchmark, a 5M-parameter CMM achieves a state-of-the-art accuracy of 93.7 %, outperforming the 27M-parameter HRM (55.0 %) and 5M-parameter TRM (87.4 %). Remarkably, even when aggressively compressed to an ultra-tiny footprint of just 0.26M parameters, the CMM retains robust predictive power, achieving 85.4 % on Sudoku-Extreme and 82.2 % on the Maze benchmark. These results establish a new frontier for extreme parameter efficiency, proving that mathematically rigorous latent dynamics can effectively replace brute-force scaling in artificial reasoning.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7

Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10170-x

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

npj Digital Medicine, Published online: 25 March 2026; doi:10.1038/s41746-026-02559-9

WiseMind: a knowledge-guided multi-agent framework for accurate and empathetic psychiatric diagnosis

Nature, Published online: 25 March 2026; doi:10.1038/d41586-026-00378-2

Two studies report the oldest dog genomes ever to be sequenced, representing leaps in scientists’ understanding of the animal’s origins.

Oncogenesis, Published online: 18 March 2026; doi:10.1038/s41389-026-00610-8

Correction: LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation

arXiv:2603.12758v1 Announce Type: cross Abstract: Reliable multi-object tracking (MOT) is essential for robotic systems operating in complex and dynamic environments. Despite recent advances in detection and association, online MOT methods remain vulnerable to identity switches caused by frequent occlusions and object overlap, where incorrect associations can propagate over time and degrade tracking reliability. We present a lightweight post-association correction framework (FC-Track) for online MOT that explicitly targets overlap-induced mismatches during inference. The proposed method suppresses unreliable appearance updates under high-overlap conditions using an Intersection over Area (IoA)-based filtering strategy, and locally corrects detection-to-tracklet mismatches through appearance similarity comparison within overlapped tracklet pairs. By preventing short-term mismatches from propagating, our framework effectively mitigates long-term identity switches without resorting to global optimization or re-identification. The framework operates online without global optimization or re-identification, making it suitable for real-time robotic applications. We achieve 81.73 MOTA, 82.81 IDF1, and 66.95 HOTA on the MOT17 test set with a running speed of 5.7 FPS, and 77.52 MOTA, 80.90 IDF1, and 65.67 HOTA on the MOT20 test set with a running speed of 0.6 FPS. Specifically, our framework FC-Track produces only 29.55% long-term identity switches, which is substantially lower than existing online trackers. Meanwhile, our framework maintains state-of-the-art performance on the MOT20 benchmark.

arXiv:2603.13056v1 Announce Type: cross Abstract: Continuous emotion recognition in terms of valence and arousal under in-the-wild (ITW) conditions remains a challenging problem due to large variations in appearance, head pose, illumination, occlusions, and subject-specific patterns of affective expression. We present a multimodal method for valence-arousal estimation ITW. Our method combines three complementary modalities: face, behavior, and audio. The face modality relies on GRADA-based frame-level embeddings and Transformer-based temporal regression. We use Qwen3-VL-4B-Instruct to extract behavior-relevant information from video segments, while Mamba is used to model temporal dynamics across segments. The audio modality relies on WavLM-Large with attention-statistics pooling and includes a cross-modal filtering stage to reduce the influence of unreliable or non-speech segments. To fuse modalities, we explore two fusion strategies: a Directed Cross-Modal Mixture-of-Experts Fusion Strategy that learns interactions between modalities with adaptive weighting, and a Reliability-Aware Audio-Visual Fusion Strategy that combines visual features at the frame-level while using audio as complementary context. The results are reported on the Aff-Wild2 dataset following the 10th Affective Behavior Analysis in-the-Wild (ABAW) challenge protocol. Experiments demonstrate that the proposed multimodal fusion strategy achieves a Concordance Correlation Coefficient (CCC) of 0.658 on the Aff-Wild2 development set.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-w

Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8

Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Background: Mammography screening uptake in Singapore remains below 40% despite campaigns and subsidies. Natural language processing (NLP) can extract nuanced attitudes from free text that fixed response options miss, revealing latent factors influencing breast cancer (BC) screening behavior. Objective: This study characterized women’s attitudes toward mammography using mixed methods data, examined associations between BC awareness and screening willingness, and identified barriers and facilitators through NLP of free-text responses. Methods: We conducted a cross-sectional study within the multicenter cohort in Singapore (October 2021-December 2023). In total, 4169 women aged 35‐59 years (median 48, IQR 43‐54) were recruited via convenience sampling (3 hospitals and 2 polyclinics). Participants completed online structured questionnaires on demographics and screening history, then a BC education quiz with feedback. Participants answering >80% correctly were classified as “BC-aware.” Posteducation, participants reported screening willingness (motivated or neutral) with optional free-text explanations. Logistic regression models (adjusted for study site, age, ethnicity, marital status, housing, and education) examined the associations with willingness. For 3819 English-language respondents, biterm topic modeling identified themes and sentiment analysis quantified emotional tone. Statistical significance: =.05. Results: Overall, 79% (3287/4169) were BC-aware, and 94% (3908/4169) reported increased motivation posteducation. BC-aware women had higher screening motivation than BC-unaware women (adjusted odds ratio [aOR] 2.88, 95% CI 2.19‐3.80;

arXiv:2603.08267v1 Announce Type: new Abstract: Bias in financial language models constitutes a major obstacle to their adoption in real-world applications. Detecting such bias is challenging, as it requires identifying inputs whose predictions change when varying properties unrelated to the decision, such as demographic attributes. Existing approaches typically rely on exhaustive mutation and pairwise prediction analysis over large corpora, which is effective but computationally expensive-particularly for large language models and can become impractical in continuous retraining and releasing processes. Aiming at reducing this cost, we conduct a large-scale study of bias in five financial language models, examining similarities in their bias tendencies across protected attributes and exploring cross-model-guided bias detection to identify bias-revealing inputs earlier. Our study uses approximately 17k real financial news sentences, mutated to construct over 125k original-mutant pairs. Results show that all models exhibit bias under both atomic (0.58\%-6.05\%) and intersectional (0.75\%-5.97\%) settings. Moreover, we observe consistent patterns in bias-revealing inputs across models, enabling substantial reuse and cost reduction in bias detection. For example, up to 73\% of FinMA's biased behaviours can be uncovered using only 20\% of the input pairs when guided by properties derived from DistilRoBERTa outputs.

arXiv:2603.08448v1 Announce Type: cross Abstract: Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p

arXiv:2603.08709v1 Announce Type: cross Abstract: Diffusion models degrade images through noise, and reversing this process reveals an information hierarchy across timesteps. Scale-space theory exhibits a similar hierarchy via low-pass filtering. We formalize this connection and show that highly noisy diffusion states contain no more information than small, downsampled images - raising the question of why they must be processed at full resolution. To address this, we fuse scale spaces into the diffusion process by formulating a family of diffusion models with generalized linear degradations and practical implementations. Using downsampling as the degradation yields our proposed Scale Space Diffusion. To support Scale Space Diffusion, we introduce Flexi-UNet, a UNet variant that performs resolution-preserving and resolution-increasing denoising using only the necessary parts of the network. We evaluate our framework on CelebA and ImageNet and analyze its scaling behavior across resolutions and network depths. Our project website ( https://prateksha.github.io/projects/scale-space-diffusion/ ) is available publicly.

arXiv:2010.01388v2 Announce Type: replace-cross Abstract: Moments when a time series changes its behavior are called change points. Occurrence of change point implies that the state of the system is altered and its timely detection might help to prevent unwanted consequences. In this paper, we present two change-point detection approaches based on neural networks and online learning. These algorithms demonstrate linear computational complexity and are suitable for change-point detection in large time series. We compare them with the best known algorithms on various synthetic and real world data sets. Experiments show that the proposed methods outperform known approaches. We also prove the convergence of the algorithms to the optimal solutions and describe conditions rendering current approach more powerful than offline one.

arXiv:2510.04602v3 Announce Type: replace-cross Abstract: Wasserstein barycenters provide a principled approach for aggregating probability measures, while preserving the geometry of their ambient space. Existing discrete methods are not scalable as they assume access to the complete set of samples from the input measures. Meanwhile, neural network approaches do scale well, but rely on complex optimization problems and cannot easily incorporate label information. We address these limitations through gradient flows in the space of probability measures. Through time discretization, we achieve a scalable algorithm that i) relies on mini-batch optimal transport, ii) accepts modular regularization through task-aware functions, and iii) seamlessly integrates supervised information into the ground-cost. We empirically validate our approach on domain adaptation benchmarks that span computer vision, neuroscience, and chemical engineering. Our method establishes a new state-of-the-art barycenter solver, with labeled barycenters consistently outperforming unlabeled ones.

arXiv:2602.00086v3 Announce Type: replace-cross Abstract: This paper addresses stock price movement prediction by leveraging LLM-based news sentiment analysis. Earlier works have largely focused on proposing and assessing sentiment analysis models and stock movement prediction methods, however, separately. Although promising results have been achieved, a clear and in-depth understanding of the benefit of the news sentiment to this task, as well as a comprehensive assessment of different architecture types in this context, is still lacking. Herein, we conduct an evaluation study that compares 3 different LLMs, namely, DeBERTa, RoBERTa and FinBERT, for sentiment-driven stock prediction. Our results suggest that DeBERTa outperforms the other two models with an accuracy of 75% and that an ensemble model that combines the three models can increase the accuracy to about 80%. Also, we see that sentiment news features can benefit (slightly) some stock market prediction models, i.e., LSTM-, PatchTST- and tPatchGNN-based classifiers and PatchTST- and TimesNet-based regression tasks models.