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Received β€” 14 March 2026 ⏭

Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer

βœ‡Omics in Gastric
By: Jinzhou Wang Β· Bishuang Xu Β· Xiaohan Lin Β· Biyu Chen Β· Xiaoyan Liu Β· Wei Wu
13 March 2026 at 18:00

Gastric Cancer. 2026 Mar 13. doi: 10.1007/s10120-026-01718-x. Online ahead of print.

ABSTRACT

BACKGROUND: 5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.

METHODS: We integrated clinical specimen analysis, in vitro and in vivo functional assays, multi-omics profiling, and molecular docking to delineate the role of the mitochondrial oxidoreductase OXNAD1 in mediating 5-FU resistance in gastric cancer, and to assess the therapeutic potential of the natural polyphenol resveratrol as a chemosensitizing agent.

RESULTS: OXNAD1 was found to be significantly overexpressed in gastric cancer tissues and cell lines, correlating with unfavorable prognosis and enhanced 5-FU resistance. Mechanistically, OXNAD1 directly bound to and suppressed the ferroptosis driver PTGS2, thereby attenuating lipid peroxidation and mitochondrial damage, ultimately restraining ferroptosis and promoting drug resistance. Notably, resveratrol disrupted the OXNAD1-PTGS2 interaction by directly binding OXNAD1, reinstating ferroptotic activity, markedly enhancing the cytotoxic effect of 5-FU in resistant cells, and potentiating the antitumor efficacy of 5-FU in xenograft models.

CONCLUSION: The OXNAD1-PTGS2 axis constitutes a critical metabolic-cell death cross-regulatory pathway underlying 5-FU resistance in gastric cancer. Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance.

PMID:41824193 | DOI:10.1007/s10120-026-01718-x

Received β€” 5 March 2026 ⏭

CoDAR: Continuous Diffusion Language Models are More Powerful Than You Think

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Junzhe Shen Β· Jieru Zhao Β· Ziwei He Β· Zhouhan Lin
4 March 2026 at 13:00
arXiv:2603.02547v1 Announce Type: cross Abstract: We study why continuous diffusion language models (DLMs) have lagged behind discrete diffusion approaches despite their appealing continuous generative dynamics. Under a controlled token--recovery study, we identify token rounding, the final projection from denoised embeddings to tokens, as a primary bottleneck. Building on these insights, we propose CoDAR (Continuous Diffusion with Contextual AutoRegressive Decoder), a two--stage framework that keeps diffusion entirely continuous in an embedding space while learning a strong, context--conditional discretizer: an autoregressive Transformer decoder that cross--attends to the denoised embedding sequence and performs contextualized rounding to tokens. Experiments on LM1B and OpenWebText demonstrate that CoDAR substantially improves generation quality over latent diffusion and becomes competitive with strong discrete DLMs, while exposing a simple decoder--temperature knob to navigate the fluency--diversity trade off.
Received β€” 17 February 2026 ⏭

AnchorWeave: World-Consistent Video Generation with Retrieved Local Spatial Memories

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Zun Wang Β· Han Lin Β· Jaehong Yoon Β· Jaemin Cho Β· Yue Zhang Β· Mohit Bansal
17 February 2026 at 13:00
arXiv:2602.14941v1 Announce Type: cross Abstract: Maintaining spatial world consistency over long horizons remains a central challenge for camera-controllable video generation. Existing memory-based approaches often condition generation on globally reconstructed 3D scenes by rendering anchor videos from the reconstructed geometry in the history. However, reconstructing a global 3D scene from multiple views inevitably introduces cross-view misalignment, as pose and depth estimation errors cause the same surfaces to be reconstructed at slightly different 3D locations across views. When fused, these inconsistencies accumulate into noisy geometry that contaminates the conditioning signals and degrades generation quality. We introduce AnchorWeave, a memory-augmented video generation framework that replaces a single misaligned global memory with multiple clean local geometric memories and learns to reconcile their cross-view inconsistencies. To this end, AnchorWeave performs coverage-driven local memory retrieval aligned with the target trajectory and integrates the selected local memories through a multi-anchor weaving controller during generation. Extensive experiments demonstrate that AnchorWeave significantly improves long-term scene consistency while maintaining strong visual quality, with ablation and analysis studies further validating the effectiveness of local geometric conditioning, multi-anchor control, and coverage-driven retrieval.
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