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cs.AI, q-bio.NC updates on arXiv.org
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Grokking From Abstraction to Intelligence
arXiv:2603.29262v1 Announce Type: new Abstract: Grokking in modular arithmetic has established itself as the quintessential fruit fly experiment, serving as a critical domain for investigating the mechanistic origins of model generalization. Despite its significance, existing research remains narrowly focused on specific local circuits or optimization tuning, largely overlooking the global structural evolution that fundamentally drives this phenomenon. We propose that grokking originates from a
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cs.AI, q-bio.NC updates on arXiv.org
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Spontaneous Functional Differentiation in Large Language Models: A Brain-Like Intelligence Economy
arXiv:2603.29735v1 Announce Type: new Abstract: The evolution of intelligence in artificial systems provides a unique opportunity to identify universal computational principles. Here we show that large language models spontaneously develop synergistic cores where information integration exceeds individual parts remarkably similar to the human brain. Using Integrated Information Decomposition across multiple architectures we find that middle layers exhibit synergistic processing while early and
Spontaneous Functional Differentiation in Large Language Models: A Brain-Like Intelligence Economy
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cs.AI, q-bio.NC updates on arXiv.org
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ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation
arXiv:2603.29902v1 Announce Type: new Abstract: Interleaved text-and-image generation represents a significant frontier for Multimodal Large Language Models (MLLMs), offering a more intuitive way to convey complex information. Current paradigms rely on either image generation or retrieval augmentation, yet they typically treat the two as mutually exclusive paths, failing to unify factuality with creativity. We argue that the next milestone in this field is Agentic Tool Planning, where the model
ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation
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cs.AI, q-bio.NC updates on arXiv.org
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LLM-Meta-SR: In-Context Learning for Evolving Selection Operators in Symbolic Regression
arXiv:2505.18602v3 Announce Type: replace-cross Abstract: Large language models (LLMs) have revolutionized algorithm development, yet their application in symbolic regression, where algorithms automatically discover symbolic expressions from data, remains limited. In this paper, we propose a meta-learning framework that enables LLMs to automatically design selection operators for evolutionary symbolic regression algorithms. We first identify two key limitations in existing LLM-based algorithm e
LLM-Meta-SR: In-Context Learning for Evolving Selection Operators in Symbolic Regression
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cs.AI, q-bio.NC updates on arXiv.org
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Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Samplin
Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
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Omics in Gastric
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Integrated transcriptomic and proteomic analyses elucidate the stress tolerance network of <em>Saccharomyces boulardii</em> under gastrointestinal challenge
Food Funct. 2026 Mar 31. doi: 10.1039/d5fo04958j. Online ahead of print.ABSTRACTThe probiotic yeast Saccharomyces boulardii is renowned for its clinical efficacy, which is intrinsically linked to its exceptional ability to survive the harsh gastrointestinal (GI) environment. However, a comprehensive understanding of the molecular mechanisms and regulatory pathways underlying the stress tolerance of S. boulardii remains limited. This study employed an integrated transcriptomic and proteomic appro
Integrated transcriptomic and proteomic analyses elucidate the stress tolerance network of <em>Saccharomyces boulardii</em> under gastrointestinal challenge
Food Funct. 2026 Mar 31. doi: 10.1039/d5fo04958j. Online ahead of print.
ABSTRACT
The probiotic yeast Saccharomyces boulardii is renowned for its clinical efficacy, which is intrinsically linked to its exceptional ability to survive the harsh gastrointestinal (GI) environment. However, a comprehensive understanding of the molecular mechanisms and regulatory pathways underlying the stress tolerance of S. boulardii remains limited. This study employed an integrated transcriptomic and proteomic approach to systematically map the dynamic responses of S. boulardii to simulated GI transit. Our analysis revealed that the intestinal phase posed a significantly greater challenge than the gastric phase, triggering extensive molecular reprogramming. A core adaptive strategy was the marked upregulation of the central carbon metabolism, particularly glycolysis, as evidenced by the concerted overexpression of key enzymes at both transcriptional and translational levels, indicating a heightened demand for energy to fuel stress defence mechanisms. Furthermore, significant enrichment was observed in the pathways related to nitrogen and fatty acid metabolism. Integration of the multi-omics datasets highlighted the complexity of the regulatory response, with frequent discordance between mRNA and protein abundance underscoring the importance of post-transcriptional regulation. This study provides a detailed molecular profile of the stress tolerance network in S. boulardii, elucidating the strategic metabolic rewiring and multi-layered regulation that underpin its probiotic resilience. The findings offer valuable insights and a foundational resource for the future development of enhanced probiotic therapies.
PMID:41914832 | DOI:10.1039/d5fo04958j
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Integrated transcriptomic and proteomic analyses elucidate the stress tolerance network of <em>Saccharomyces boulardii</em> under gastrointestinal challenge
Food Funct. 2026 Mar 31. doi: 10.1039/d5fo04958j. Online ahead of print.ABSTRACTThe probiotic yeast Saccharomyces boulardii is renowned for its clinical efficacy, which is intrinsically linked to its exceptional ability to survive the harsh gastrointestinal (GI) environment. However, a comprehensive understanding of the molecular mechanisms and regulatory pathways underlying the stress tolerance of S. boulardii remains limited. This study employed an integrated transcriptomic and proteomic appro
Integrated transcriptomic and proteomic analyses elucidate the stress tolerance network of <em>Saccharomyces boulardii</em> under gastrointestinal challenge
Food Funct. 2026 Mar 31. doi: 10.1039/d5fo04958j. Online ahead of print.
ABSTRACT
The probiotic yeast Saccharomyces boulardii is renowned for its clinical efficacy, which is intrinsically linked to its exceptional ability to survive the harsh gastrointestinal (GI) environment. However, a comprehensive understanding of the molecular mechanisms and regulatory pathways underlying the stress tolerance of S. boulardii remains limited. This study employed an integrated transcriptomic and proteomic approach to systematically map the dynamic responses of S. boulardii to simulated GI transit. Our analysis revealed that the intestinal phase posed a significantly greater challenge than the gastric phase, triggering extensive molecular reprogramming. A core adaptive strategy was the marked upregulation of the central carbon metabolism, particularly glycolysis, as evidenced by the concerted overexpression of key enzymes at both transcriptional and translational levels, indicating a heightened demand for energy to fuel stress defence mechanisms. Furthermore, significant enrichment was observed in the pathways related to nitrogen and fatty acid metabolism. Integration of the multi-omics datasets highlighted the complexity of the regulatory response, with frequent discordance between mRNA and protein abundance underscoring the importance of post-transcriptional regulation. This study provides a detailed molecular profile of the stress tolerance network in S. boulardii, elucidating the strategic metabolic rewiring and multi-layered regulation that underpin its probiotic resilience. The findings offer valuable insights and a foundational resource for the future development of enhanced probiotic therapies.
PMID:41914832 | DOI:10.1039/d5fo04958j
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cs.AI, q-bio.NC updates on arXiv.org
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Toward Faithful Segmentation Attribution via Benchmarking and Dual-Evidence Fusion
arXiv:2603.22624v1 Announce Type: cross Abstract: Attribution maps for semantic segmentation are almost always judged by visual plausibility. Yet looking convincing does not guarantee that the highlighted pixels actually drive the model's prediction, nor that attribution credit stays within the target region. These questions require a dedicated evaluation protocol. We introduce a reproducible benchmark that tests intervention-based faithfulness, off-target leakage, perturbation robustness, and
Toward Faithful Segmentation Attribution via Benchmarking and Dual-Evidence Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
arXiv:2603.23064v2 Announce Type: cross Abstract: We identify a critical security vulnerability in mainstream Claw personal AI agents: untrusted content encountered during heartbeat-driven background execution can silently pollute agent memory and subsequently influence user-facing behavior without the user's awareness. This vulnerability arises from an architectural design shared across the Claw ecosystem: heartbeat background execution runs in the same session as user-facing conversation, so
Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
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cs.AI, q-bio.NC updates on arXiv.org
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Generalizable Heuristic Generation Through LLMs with Meta-Optimization
arXiv:2505.20881v2 Announce Type: replace-cross Abstract: Heuristic design with large language models (LLMs) has emerged as a promising approach for tackling combinatorial optimization problems (COPs). However, existing approaches often rely on manually predefined evolutionary computation (EC) heuristic-optimizers and single-task training schemes, which may constrain the exploration of diverse heuristic algorithms and hinder the generalization of the resulting heuristics. To address these issue
Generalizable Heuristic Generation Through LLMs with Meta-Optimization
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Cell Death Discovery nature.com science feeds
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Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models
Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03045-7Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models
Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models
Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03045-7
Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis
Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.ABSTRACTPURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analy
NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis
Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.
ABSTRACT
PURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.
METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Cancer Cell Line Encyclopedia (CCLE), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), CellMiner, and GeneMANIA databases, we investigated the role of NUP85 across various tumors. Correlations between NUP85 expression and pathological stage, histological grade, survival, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), drug resistance, DNA methylation, copy number variation (CNV), and single-cell expression were analyzed. Gene functional enrichment analysis was conducted to explore NUP85-associated pathways. Molecular biology experiments including Western blotting, flow cytometry, trans-well migration, and invasion assays were performed to validate NUP85's oncogenic role in lung adenocarcinoma (LUAD) and oral squamous cell carcinoma (OSCC) cell lines.
RESULTS: Our findings reveal up-regulated expression of NUP85 in most tumor tissues, with significant correlations observed with pathological stage, survival, immune infiltration, TMB, MSI, drug resistance, DNA methylation, and CNV. Molecular biology experiments confirm NUP85's tumor-promoting role in LUAD and OSCC cell lines. Single-cell sequencing data suggest elevated NUP85 expression primarily in proliferative T cells (Tprolif).
CONCLUSION: NUP85 emerges as a potential tumor marker associated with tumor immunity and poor prognosis. These insights offer avenues for the development of novel therapeutic targets and anti-neoplastic drugs.
PMID:41869435 | PMC:PMC13005628 | DOI:10.2147/ITT.S541852
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cs.AI, q-bio.NC updates on arXiv.org
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Towards AI Search Paradigm
arXiv:2506.17188v2 Announce Type: replace-cross Abstract: In this paper, we introduce the AI Search Paradigm, a comprehensive blueprint for next-generation search systems capable of emulating human information processing and decision-making. The paradigm employs a modular architecture of four LLM-powered agents (Master, Planner, Executor and Writer) that dynamically adapt to the full spectrum of information needs, from simple factual queries to complex multi-stage reasoning tasks. These agents
Towards AI Search Paradigm
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cs.AI, q-bio.NC updates on arXiv.org
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SvfEye: A Semantic-Visual Fusion Framework with Multi-Scale Visual Context for Multimodal Reasoning
arXiv:2603.00171v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) often struggle to accurately perceive fine-grained visual details, especially when targets are tiny or visually subtle. This challenge can be addressed through semantic-visual information fusion, which integrates global image context with fine-grained local evidence for multi-scale visual understanding. Recently, a paradigm termed "Thinking with Images" has emerged, enabling models to acquire high
SvfEye: A Semantic-Visual Fusion Framework with Multi-Scale Visual Context for Multimodal Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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A Simple "Motivation" Can Enhance Reinforcement Finetuning of Large Reasoning Models
arXiv:2506.18485v3 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards~(RLVR) has emerged as a powerful learn-to-reason paradigm for large reasoning models to tackle complex tasks. However, the current RLVR paradigm is still not efficient enough, as it works in a trial-and-error manner. To perform better, the model needs to explore the reward space by numerously generating responses and learn from fragmented reward signals, blind to the overall reward patterns.
A Simple "Motivation" Can Enhance Reinforcement Finetuning of Large Reasoning Models
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cs.AI, q-bio.NC updates on arXiv.org
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Video-EM: Event-Centric Episodic Memory for Long-Form Video Understanding
arXiv:2508.09486v2 Announce Type: replace-cross Abstract: Video Large Language Models (Video-LLMs) have shown strong video understanding, yet their application to long-form videos remains constrained by limited context windows. A common workaround is to compress long videos into a handful of representative frames via retrieval or summarization. However, most existing pipelines score frames in isolation, implicitly assuming that frame-level saliency is sufficient for downstream reasoning. This o
Video-EM: Event-Centric Episodic Memory for Long-Form Video Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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LMMRec: LLM-driven Motivation-aware Multimodal Recommendation
arXiv:2602.05474v3 Announce Type: replace-cross Abstract: Motivation-based recommendation systems uncover user behavior drivers. Motivation modeling, crucial for decision-making and content preference, explains recommendation generation. Existing methods often treat motivation as latent variables from interaction data, neglecting heterogeneous information like review text. In multimodal motivation fusion, two challenges arise: 1) achieving stable cross-modal alignment amid noise, and 2) identif
LMMRec: LLM-driven Motivation-aware Multimodal Recommendation
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Generalized Multimodal Homography Estimation
arXiv:2603.03956v1 Announce Type: cross Abstract: Supervised and unsupervised homography estimation methods depend on image pairs tailored to specific modalities to achieve high accuracy. However, their performance deteriorates substantially when applied to unseen modalities. To address this issue, we propose a training data synthesis method that generates unaligned image pairs with ground-truth offsets from a single input image. Our approach renders the image pairs with diverse textures and co
Towards Generalized Multimodal Homography Estimation
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cs.AI, q-bio.NC updates on arXiv.org
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TrustMH-Bench: A Comprehensive Benchmark for Evaluating the Trustworthiness of Large Language Models in Mental Health
arXiv:2603.03047v1 Announce Type: cross Abstract: While Large Language Models (LLMs) demonstrate significant potential in providing accessible mental health support, their practical deployment raises critical trustworthiness concerns due to the domains high-stakes and safety-sensitive nature. Existing evaluation paradigms for general-purpose LLMs fail to capture mental health-specific requirements, highlighting an urgent need to prioritize and enhance their trustworthiness. To address this, we
TrustMH-Bench: A Comprehensive Benchmark for Evaluating the Trustworthiness of Large Language Models in Mental Health
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cs.AI, q-bio.NC updates on arXiv.org
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STCast: Adaptive Boundary Alignment for Global and Regional Weather Forecasting
arXiv:2509.25210v2 Announce Type: replace-cross Abstract: To gain finer regional forecasts, many works have explored the regional integration from the global atmosphere, e.g., by solving boundary equations in physics-based methods or cropping regions from global forecasts in data-driven methods. However, the effectiveness of these methods is often constrained by static and imprecise regional boundaries, resulting in poor generalization ability. To address this issue, we propose Spatial-Temporal