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cs.AI, q-bio.NC updates on arXiv.org
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Design Principles for the Construction of a Benchmark Evaluating Security Operation Capabilities of Multi-agent AI Systems
arXiv:2603.28998v1 Announce Type: cross Abstract: As Large Language Models (LLMs) and multi-agent AI systems are demonstrating increasing potential in cybersecurity operations, organizations, policymakers, model providers, and researchers in the AI and cybersecurity communities are interested in quantifying the capabilities of such AI systems to achieve more autonomous SOCs (security operation centers) and reduce manual effort. In particular, the AI and cybersecurity communities have recently d
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cs.AI, q-bio.NC updates on arXiv.org
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Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
arXiv:2603.25158v3 Announce Type: replace Abstract: Equipping Large Language Model (LLM) agents with domain-specific skills is critical for tackling complex tasks. Yet, manual authoring creates a severe scalability bottleneck. Conversely, automated skill generation often yields fragile or fragmented results because it either relies on shallow parametric knowledge or sequentially overfits to non-generalizable trajectory-local lessons. To overcome this, we introduce Trace2Skill, a framework that
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes
Gut. 2026 Feb 9;75(3):576-587. doi: 10.1136/gutjnl-2025-337506.ABSTRACTBACKGROUND: Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).OBJECTIVE: To evaluate this approach for predicting advanced fibrosis and liver-related events (LREs) in patients with type 2 diabete
Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes
Gut. 2026 Feb 9;75(3):576-587. doi: 10.1136/gutjnl-2025-337506.
ABSTRACT
BACKGROUND: Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).
OBJECTIVE: To evaluate this approach for predicting advanced fibrosis and liver-related events (LREs) in patients with type 2 diabetes (T2D).
DESIGN: A prospective liver biopsy cohort of T2D patients with histologically confirmed MASLD from seven centres in China was used to assess diagnostic performance for advanced fibrosis. The international VCTE-Prognosis cohort, including T2D patients with MASLD who underwent VCTE at 16 centres in the USA, Europe and Asia, with longitudinal follow-up, was used to assess LREs, defined as hepatic decompensation or hepatocellular carcinoma.
RESULTS: 4781 participants were included. In the liver biopsy cohort (n=352; 22.2% with advanced fibrosis), applying LSM thresholds of <8 kPa and >12 kPa after FIB-4 classified patients into 63.4% low-risk, 9.4% intermediate-risk and 27.3% high-risk, with a correct classification rate of 71%. In the VCTE-Prognosis cohort (n=4429; median follow-up 51.3 (IQR 27.4-70.7) months), 140 (3.2%) patients developed LREs (110 (2.5%) with hepatic decompensation and 59 (1.3%) with hepatocellular carcinoma). The two-step approach classified 72.6%, 6.8% and 20.6% of patients into low-risk, intermediate-risk and high-risk groups, with corresponding 5-year cumulative LRE incidences of 0.7%, 0.9% and 11.8%. Refining classification of intermediate FIB-4 patients using LSM <10 kPa (low-risk) and >15 kPa (high-risk) reduced the intermediate-risk group to 5.6% while preserving predictive accuracy.
CONCLUSION: The non-invasive two-step approach of FIB-4 followed by LSM effectively stratifies MASLD-related advanced fibrosis and LREs risk in T2D. Applying LSM cut-offs of 10 and 15 kPa further optimises risk stratification for future LREs.
PMID:41911049 | DOI:10.1136/gutjnl-2025-337506
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cs.AI, q-bio.NC updates on arXiv.org
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UAV-DETR: DETR for Anti-Drone Target Detection
arXiv:2603.22841v1 Announce Type: cross Abstract: Drone detection is pivotal in numerous security and counter-UAV applications. However, existing deep learning-based methods typically struggle to balance robust feature representation with computational efficiency. This challenge is particularly acute when detecting miniature drones against complex backgrounds under severe environmental interference. To address these issues, we introduce UAV-DETR, a novel framework that integrates a small-target
UAV-DETR: DETR for Anti-Drone Target Detection
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cs.AI, q-bio.NC updates on arXiv.org
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3DCity-LLM: Empowering Multi-modality Large Language Models for 3D City-scale Perception and Understanding
arXiv:2603.23447v1 Announce Type: cross Abstract: While multi-modality large language models excel in object-centric or indoor scenarios, scaling them to 3D city-scale environments remains a formidable challenge. To bridge this gap, we propose 3DCity-LLM, a unified framework designed for 3D city-scale vision-language perception and understanding. 3DCity-LLM employs a coarse-to-fine feature encoding strategy comprising three parallel branches for target object, inter-object relationship, and glo
3DCity-LLM: Empowering Multi-modality Large Language Models for 3D City-scale Perception and Understanding
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Omics In Lung
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Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells
World J Oncol. 2026 Mar 5;17(2):247-255. doi: 10.14740/wjon2689. eCollection 2026 Apr.ABSTRACTBACKGROUND: We aimed to evaluate the potential association between genetically predicted vanin-2 (VNN2) expression and lung adenocarcinoma (LUAD) risk, and to explore the immune cell subtype that may underlie this relationship.METHODS: We integrated whole-blood expression quantitative trait loci (eQTL) data from eQTLGen, plasma protein quantitative trait loci (pQTL) data from deCODE, and LUAD genome-wid
Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells
World J Oncol. 2026 Mar 5;17(2):247-255. doi: 10.14740/wjon2689. eCollection 2026 Apr.
ABSTRACT
BACKGROUND: We aimed to evaluate the potential association between genetically predicted vanin-2 (VNN2) expression and lung adenocarcinoma (LUAD) risk, and to explore the immune cell subtype that may underlie this relationship.
METHODS: We integrated whole-blood expression quantitative trait loci (eQTL) data from eQTLGen, plasma protein quantitative trait loci (pQTL) data from deCODE, and LUAD genome-wide association study (GWAS) data from European-ancestry cohorts, together with differential expression analysis using GEPIA2, to identify candidate genes for subsequent single-cell eQTL (sc-eQTL) Mendelian randomization (MR) analysis. For the sc-eQTL analysis, VNN2-associated eQTLs from 14 immune cell types profiled in the OneK1K single-cell eQTL resource were tested for associations with LUAD risk.
RESULTS: Bulk-level MR analysis showed that genetically predicted increases in VNN2 expression and protein levels were significantly associated with a reduced risk of LUAD (eQTL-MR: odds ratio (OR) = 0.964, 95% confidence interval (95% CI), 0.934-0.995; P = 0.024; pQTL-MR: OR = 0.946, 95% CI, 0.921-0.970; P = 2.87 × 10-5). Transcriptomic analyses confirmed significant downregulation of VNN2 in LUAD tumors compared with normal lung tissues. sc-eQTL MR identified the strongest association in resting natural killer (rNK) cells (OR = 0.896, 95% CI, 0.829-0.967; P = 0.005).
CONCLUSIONS: Multi-omics and sc-eQTL MR analyses indicated that genetically predicted increases in VNN2 expression were associated with a reduced risk of LUAD, with the most pronounced effect observed in rNK cells. These findings suggest a potential cell type-specific role of VNN2 in LUAD susceptibility and warrant further studies to validate its biological relevance and clinical implications.
PMID:41822323 | PMC:PMC12978397 | DOI:10.14740/wjon2689
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Oncogenesis - nature.com science feeds
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Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Oncogenesis, Published online: 11 March 2026; doi:10.1038/s41389-026-00605-5Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Oncogenesis, Published online: 11 March 2026; doi:10.1038/s41389-026-00605-5
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma-
cs.AI, q-bio.NC updates on arXiv.org
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CoCo: Code as CoT for Text-to-Image Preview and Rare Concept Generation
arXiv:2603.08652v1 Announce Type: new Abstract: Recent advancements in Unified Multimodal Models (UMMs) have significantly advanced text-to-image (T2I) generation, particularly through the integration of Chain-of-Thought (CoT) reasoning. However, existing CoT-based T2I methods largely rely on abstract natural-language planning, which lacks the precision required for complex spatial layouts, structured visual elements, and dense textual content. In this work, we propose CoCo (Code-as-CoT), a cod
CoCo: Code as CoT for Text-to-Image Preview and Rare Concept Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Improved Constrained Generation by Bridging Pretrained Generative Models
arXiv:2603.06742v1 Announce Type: cross Abstract: Constrained generative modeling is fundamental to applications such as robotic control and autonomous driving, where models must respect physical laws and safety-critical constraints. In real-world settings, these constraints rarely take the form of simple linear inequalities, but instead complex feasible regions that resemble road maps or other structured spatial domains. We propose a constrained generation framework that generates samples dire
Improved Constrained Generation by Bridging Pretrained Generative Models
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cs.AI, q-bio.NC updates on arXiv.org
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iGVLM: Dynamic Instruction-Guided Vision Encoding for Question-Aware Multimodal Understanding
arXiv:2603.02748v2 Announce Type: replace-cross Abstract: Despite the success of Large Vision--Language Models (LVLMs), most existing architectures suffer from a representation bottleneck: they rely on static, instruction-agnostic vision encoders whose visual representations are utilized in an invariant manner across different textual tasks. This rigidity hinders fine-grained reasoning where task-specific visual cues are critical. To address this issue, we propose iGVLM, a general framework for
iGVLM: Dynamic Instruction-Guided Vision Encoding for Question-Aware Multimodal Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
arXiv:2603.02767v3 Announce Type: replace-cross Abstract: Image-text contrastive pretraining has become a dominant paradigm for visual representation learning, yet existing methods often yield representations that remain partially organized by modality. We propose ITO, a framework addressing this limitation through two synergistic mechanisms. Multimodal multiple alignment enriches supervision by mining diverse image-text correspondences, while a lightweight training-time multimodal fusion modul
ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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Separators in Enhancing Autoregressive Pretraining for Vision Mamba
arXiv:2603.03806v1 Announce Type: cross Abstract: The state space model Mamba has recently emerged as a promising paradigm in computer vision, attracting significant attention due to its efficient processing of long sequence tasks. Mamba's inherent causal mechanism renders it particularly suitable for autoregressive pretraining. However, current autoregressive pretraining methods are constrained to short sequence tasks, failing to fully exploit Mamba's prowess in handling extended sequences. To
Separators in Enhancing Autoregressive Pretraining for Vision Mamba
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cs.AI, q-bio.NC updates on arXiv.org
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ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
arXiv:2603.02767v2 Announce Type: replace-cross Abstract: Image-text contrastive pretraining has become a dominant paradigm for visual representation learning, yet existing methods often yield representations that remain partially organized by modality. We propose ITO, a framework addressing this limitation through two synergistic mechanisms. Multimodal multiple alignment enriches supervision by mining diverse image-text correspondences, while a lightweight training-time multimodal fusion modul
ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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iGVLM: Dynamic Instruction-Guided Vision Encoding for Question-Aware Multimodal Understanding
arXiv:2603.02748v1 Announce Type: cross Abstract: Despite the success of Large Vision--Language Models (LVLMs), most existing architectures suffer from a representation bottleneck: they rely on static, instruction-agnostic vision encoders whose visual representations are utilized in an invariant manner across different textual tasks. This rigidity hinders fine-grained reasoning where task-specific visual cues are critical. To address this issue, we propose iGVLM, a general framework for instruc
iGVLM: Dynamic Instruction-Guided Vision Encoding for Question-Aware Multimodal Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
arXiv:2603.02767v1 Announce Type: cross Abstract: Image-text contrastive pretraining has become a dominant paradigm for visual representation learning, yet existing methods often yield representations that remain partially organized by modality. We propose ITO, a framework addressing this limitation through two synergistic mechanisms. Multimodal multiple alignment enriches supervision by mining diverse image-text correspondences, while a lightweight training-time multimodal fusion module enforc
ITO: Images and Texts as One via Synergizing Multiple Alignment and Training-Time Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
arXiv:2602.19326v1 Announce Type: cross Abstract: As cities evolve over time, challenges such as traffic congestion and functional imbalance increasingly necessitate urban renewal through efficient modification of existing plans, rather than complete re-planning. In practice, even minor urban changes require substantial manual effort to redraw geospatial layouts, slowing the iterative planning and decision-making procedure. Motivated by recent advances in agentic systems and multimodal reasonin
City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
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cs.AI, q-bio.NC updates on arXiv.org
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Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction
Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
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cs.AI, q-bio.NC updates on arXiv.org
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Hierarchical Audio-Visual-Proprioceptive Fusion for Precise Robotic Manipulation
arXiv:2602.13640v1 Announce Type: cross Abstract: Existing robotic manipulation methods primarily rely on visual and proprioceptive observations, which may struggle to infer contact-related interaction states in partially observable real-world environments. Acoustic cues, by contrast, naturally encode rich interaction dynamics during contact, yet remain underexploited in current multimodal fusion literature. Most multimodal fusion approaches implicitly assume homogeneous roles across modalities
Hierarchical Audio-Visual-Proprioceptive Fusion for Precise Robotic Manipulation
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cs.AI, q-bio.NC updates on arXiv.org
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From SFT to RL: Demystifying the Post-Training Pipeline for LLM-based Vulnerability Detection
arXiv:2602.14012v1 Announce Type: cross Abstract: The integration of LLMs into vulnerability detection (VD) has shifted the field toward interpretable and context-aware analysis. While post-training methods have shown promise in general coding tasks, their systematic application to VD remains underexplored. In this paper, we present the first comprehensive investigation into the post-training pipeline for LLM-based VD, spanning from cold-start SFT to off-policy preference optimization and on-po
From SFT to RL: Demystifying the Post-Training Pipeline for LLM-based Vulnerability Detection
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cs.AI, q-bio.NC updates on arXiv.org
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Dataforge: Agentic Platform for Autonomous Data Engineering
arXiv:2511.06185v2 Announce Type: replace Abstract: The growing demand for artificial intelligence (AI) applications in materials discovery, molecular modeling, and climate science has made data preparation a critical but labor-intensive bottleneck. Raw data from diverse sources must be cleaned, normalized, and transformed to become AI-ready, where effective feature transformation and selection are essential for robust learning. We present Dataforge, an LLM-powered agentic data engineering plat