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cs.AI, q-bio.NC updates on arXiv.org
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Learning to Generate Formally Verifiable Step-by-Step Logic Reasoning via Structured Formal Intermediaries
arXiv:2603.29500v1 Announce Type: new Abstract: Large language models (LLMs) have recently demonstrated impressive performance on complex, multi-step reasoning tasks, especially when post-trained with outcome-rewarded reinforcement learning Guo et al. 2025. However, it has been observed that outcome rewards often overlook flawed intermediate steps, leading to unreliable reasoning steps even when final answers are correct. To address this unreliable reasoning, we propose PRoSFI (Process Reward o
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cs.AI, q-bio.NC updates on arXiv.org
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DF-ACBlurGAN: Structure-Aware Conditional Generation of Internally Repeated Patterns for Biomaterial Microtopography Design
arXiv:2603.28776v1 Announce Type: cross Abstract: Learning to generate images with internally repeated and periodic structures poses a fundamental challenge for machine learning and computer vision models, which are typically optimised for local texture statistics and semantic realism rather than global structural consistency. This limitation is particularly pronounced in applications requiring strict control over repetition scale, spacing, and boundary coherence, such as microtopographical bio
DF-ACBlurGAN: Structure-Aware Conditional Generation of Internally Repeated Patterns for Biomaterial Microtopography Design
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Omics In Lung
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Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications
Front Immunol. 2026 Mar 13;17:1770348. doi: 10.3389/fimmu.2026.1770348. eCollection 2026.ABSTRACTInterstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory failure, which impacts quality of life and can even be life-threatening. This review identified genetic susceptibility, environmental factors, and immun
Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications
Front Immunol. 2026 Mar 13;17:1770348. doi: 10.3389/fimmu.2026.1770348. eCollection 2026.
ABSTRACT
Interstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory failure, which impacts quality of life and can even be life-threatening. This review identified genetic susceptibility, environmental factors, and immune dysregulation as key contributors to the etiology and pathogenesis of RA-ILD. We highlight that autoantibodies, adaptive immune abnormalities, and tertiary lymphoid organ formation significantly drive pulmonary inflammation and fibrosis, while pro-inflammatory cytokines and epithelial-mesenchymal transition (EMT) further contribute to lung tissue injury. Current treatment options, including glucocorticoids, immunosuppressants, and antifibrotic agents such as nintedanib and pirfenidone, are often limited by substantial side effects. Additionally, emerging therapies like JAK inhibitors, CAR-T cells, and the upcoming phosphodiesterase-4B inhibitor, nerandomilast, show promise, but no curative treatment exists to date. Future research could focus on multi-omics technologies and conducting multicenter clinical trials to establish therapeutic targets and advance precision medicine for RA-ILD.
PMID:41909710 | PMC:PMC13021622 | DOI:10.3389/fimmu.2026.1770348
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cs.AI, q-bio.NC updates on arXiv.org
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Reasoning over Semantic IDs Enhances Generative Recommendation
arXiv:2603.23183v1 Announce Type: cross Abstract: Recent advances in generative recommendation have leveraged pretrained LLMs by formulating sequential recommendation as autoregressive generation over a unified token space comprising language tokens and itemic identifiers, where each item is represented by a compact sequence of discrete tokens, namely Semantic IDs (SIDs). This SID-based formulation enables efficient decoding over large-scale item corpora and provides a natural interface for LLM
Reasoning over Semantic IDs Enhances Generative Recommendation
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cs.AI, q-bio.NC updates on arXiv.org
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Efficient Reasoning with Balanced Thinking
arXiv:2603.12372v1 Announce Type: new Abstract: Large Reasoning Models (LRMs) have shown remarkable reasoning capabilities, yet they often suffer from overthinking, expending redundant computational steps on simple problems, or underthinking, failing to explore sufficient reasoning paths despite inherent capabilities. These issues lead to inefficiencies and potential inaccuracies, limiting practical deployment in resource-constrained settings. Existing methods to mitigate overthinking, such as
Efficient Reasoning with Balanced Thinking
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cs.AI, q-bio.NC updates on arXiv.org
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CCMamba: Topologically-Informed Selective State-Space Networks on Combinatorial Complexes for Higher-Order Graph Learning
arXiv:2601.20518v2 Announce Type: replace-cross Abstract: Topological deep learning has emerged as a powerful paradigm for modeling higher-order relational structures beyond pairwise interactions that standard graph neural networks fail to capture. While combinatorial complexes (CCs) offer a unified topological foundation for the higher-order graph learning, existing topological deep learning methods rely heavily on local message passing and attention mechanisms. These suffer from quadratic com
CCMamba: Topologically-Informed Selective State-Space Networks on Combinatorial Complexes for Higher-Order Graph Learning
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cs.AI, q-bio.NC updates on arXiv.org
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UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
arXiv:2603.08117v1 Announce Type: new Abstract: Recent advancements in LLM-based information-seeking agents have achieved record-breaking performance on established benchmarks. However, these agents remain heavily reliant on search-engine-indexed knowledge, leaving a critical blind spot: Unindexed Information Seeking (UIS). This paper identifies and explores the UIS problem, where vital information is not captured by search engine crawlers, such as overlooked content, dynamic webpages, and embe
UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
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cs.AI, q-bio.NC updates on arXiv.org
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Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
arXiv:2602.13810v2 Announce Type: replace-cross Abstract: Learning expressive and efficient policy functions is a promising direction in reinforcement learning (RL). While flow-based policies have recently proven effective in modeling complex action distributions with a fast deterministic sampling process, they still face a trade-off between expressiveness and computational burden, which is typically controlled by the number of flow steps. In this work, we propose mean velocity policy (MVP), a
Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
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Nature Cancer
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CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off
Nature Cancer, Published online: 05 March 2026; doi:10.1038/s43018-026-01135-0Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.
CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off
Nature Cancer, Published online: 05 March 2026; doi:10.1038/s43018-026-01135-0
Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.-
cs.AI, q-bio.NC updates on arXiv.org
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Towards Self-Robust LLMs: Intrinsic Prompt Noise Resistance via CoIPO
arXiv:2603.03314v1 Announce Type: cross Abstract: Large language models (LLMs) have demonstrated remarkable and steadily improving performance across a wide range of tasks. However, LLM performance may be highly sensitive to prompt variations especially in scenarios with limited openness or strict output formatting requirements, indicating insufficient robustness. In real-world applications, user prompts provided to LLMs often contain imperfections, which may undermine the quality of the model'
Towards Self-Robust LLMs: Intrinsic Prompt Noise Resistance via CoIPO
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Generalized Multimodal Homography Estimation
arXiv:2603.03956v1 Announce Type: cross Abstract: Supervised and unsupervised homography estimation methods depend on image pairs tailored to specific modalities to achieve high accuracy. However, their performance deteriorates substantially when applied to unseen modalities. To address this issue, we propose a training data synthesis method that generates unaligned image pairs with ground-truth offsets from a single input image. Our approach renders the image pairs with diverse textures and co
Towards Generalized Multimodal Homography Estimation
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cs.AI, q-bio.NC updates on arXiv.org
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TFWaveFormer: Temporal-Frequency Collaborative Multi-level Wavelet Transformer for Dynamic Link Prediction
arXiv:2603.03963v1 Announce Type: cross Abstract: Dynamic link prediction plays a crucial role in diverse applications including social network analysis, communication forecasting, and financial modeling. While recent Transformer-based approaches have demonstrated promising results in temporal graph learning, their performance remains limited when capturing complex multi-scale temporal dynamics. In this paper, we propose TFWaveFormer, a novel Transformer architecture that integrates temporal-fr
TFWaveFormer: Temporal-Frequency Collaborative Multi-level Wavelet Transformer for Dynamic Link Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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RANGER: Sparsely-Gated Mixture-of-Experts with Adaptive Retrieval Re-ranking for Pathology Report Generation
arXiv:2603.04348v1 Announce Type: cross Abstract: Pathology report generation remains a relatively under-explored downstream task, primarily due to the gigapixel scale and complex morphological heterogeneity of Whole Slide Images (WSIs). Existing pathology report generation frameworks typically employ transformer architectures, relying on a homogeneous decoder architecture and static knowledge retrieval integration. Such architectures limit generative specialization and may introduce noisy exte
RANGER: Sparsely-Gated Mixture-of-Experts with Adaptive Retrieval Re-ranking for Pathology Report Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Semantic-level Backdoor Attack against Text-to-Image Diffusion Models
arXiv:2602.04898v2 Announce Type: replace-cross Abstract: Text-to-image (T2I) diffusion models are widely adopted for their strong generative capabilities, yet remain vulnerable to backdoor attacks. Existing attacks typically rely on fixed textual triggers and single-entity backdoor targets, making them highly susceptible to enumeration-based input defenses and attention-consistency detection. In this work, we propose Semantic-level Backdoor Attack (SemBD), which implants backdoors at the repre
Semantic-level Backdoor Attack against Text-to-Image Diffusion Models
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cs.AI, q-bio.NC updates on arXiv.org
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Spatio-Temporal Graphical Counterfactuals: An Overview
arXiv:2407.01875v3 Announce Type: replace Abstract: Counterfactual thinking is a crucial yet challenging topic for artificial intelligence to learn knowledge from data and ultimately improve performance for new scenarios. Many research works, including the Potential Outcome Model (POM) and the Structural Causal Model (SCM), have been proposed to address this. However, their modeling, theoretical foundations, and application approaches often differ. Moreover, there is a lack of graphical approac
Spatio-Temporal Graphical Counterfactuals: An Overview
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cs.AI, q-bio.NC updates on arXiv.org
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MemOCR: Layout-Aware Visual Memory for Efficient Long-Horizon Reasoning
arXiv:2601.21468v3 Announce Type: replace Abstract: Long-horizon agentic reasoning necessitates effectively compressing growing interaction histories into a limited context window. Most existing memory systems serialize history as text, where token-level cost is uniform and scales linearly with length, often spending scarce budget on low-value details. To this end, we introduce MemOCR, a multimodal memory agent that improves long-horizon reasoning under tight context budgets by allocating memor
MemOCR: Layout-Aware Visual Memory for Efficient Long-Horizon Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Look Back to Reason Forward: Revisitable Memory for Long-Context LLM Agents
arXiv:2509.23040v4 Announce Type: replace-cross Abstract: Large language models face challenges in long-context question answering, where key evidence of a query may be dispersed across millions of tokens. Existing works equip large language models with a memory buffer that is dynamically updated via a linear document scan, also known as the "memorize while reading" methods. While this approach scales efficiently, it suffers from pruning of latent evidence, information loss through overwriting,
Look Back to Reason Forward: Revisitable Memory for Long-Context LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Transport and Merge: Cross-Architecture Merging for Large Language Models
arXiv:2602.05495v2 Announce Type: replace-cross Abstract: Large language models (LLMs) achieve strong capabilities by scaling model capacity and training data, yet many real-world deployments rely on smaller models trained or adapted from low-resource data. This gap motivates the need for mechanisms to transfer knowledge from large, high-resource models to smaller, low-resource targets. While model merging provides an effective transfer mechanism, most existing approaches assume architecture-co
Transport and Merge: Cross-Architecture Merging for Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
arXiv:2602.13810v1 Announce Type: cross Abstract: Learning expressive and efficient policy functions is a promising direction in reinforcement learning (RL). While flow-based policies have recently proven effective in modeling complex action distributions with a fast deterministic sampling process, they still face a trade-off between expressiveness and computational burden, which is typically controlled by the number of flow steps. In this work, we propose mean velocity policy (MVP), a new gene
Mean Flow Policy with Instantaneous Velocity Constraint for One-step Action Generation
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cs.AI, q-bio.NC updates on arXiv.org
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On the Learning Dynamics of RLVR at the Edge of Competence
arXiv:2602.14872v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has been a main driver of recent breakthroughs in large reasoning models. Yet it remains a mystery how rewards based solely on final outcomes can help overcome the long-horizon barrier to extended reasoning. To understand this, we develop a theory of the training dynamics of RL for transformers on compositional reasoning tasks. Our theory characterizes how the effectiveness of RLVR is governe