Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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PAR$^2$-RAG: Planned Active Retrieval and Reasoning for Multi-Hop Question Answering
arXiv:2603.29085v1 Announce Type: new Abstract: Large language models (LLMs) remain brittle on multi-hop question answering (MHQA), where answering requires combining evidence across documents through retrieval and reasoning. Iterative retrieval systems can fail by locking onto an early low-recall trajectory and amplifying downstream errors, while planning-only approaches may produce static query sets that cannot adapt when intermediate evidence changes. We propose \textbf{Planned Active Retrie
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cs.AI, q-bio.NC updates on arXiv.org
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PSPA-Bench: A Personalized Benchmark for Smartphone GUI Agent
arXiv:2603.29318v1 Announce Type: new Abstract: Smartphone GUI agents execute tasks by operating directly on app interfaces, offering a path to broad capability without deep system integration. However, real-world smartphone use is highly personalized: users adopt diverse workflows and preferences, challenging agents to deliver customized assistance rather than generic solutions. Existing GUI agent benchmarks cannot adequately capture this personalization dimension due to sparse user-specific d
PSPA-Bench: A Personalized Benchmark for Smartphone GUI Agent
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cs.AI, q-bio.NC updates on arXiv.org
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Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data
Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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RAAP: Retrieval-Augmented Affordance Prediction with Cross-Image Action Alignment
arXiv:2603.29419v1 Announce Type: cross Abstract: Understanding object affordances is essential for enabling robots to perform purposeful and fine-grained interactions in diverse and unstructured environments. However, existing approaches either rely on retrieval, which is fragile due to sparsity and coverage gaps, or on large-scale models, which frequently mislocalize contact points and mispredict post-contact actions when applied to unseen categories, thereby hindering robust generalization.
RAAP: Retrieval-Augmented Affordance Prediction with Cross-Image Action Alignment
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cs.AI, q-bio.NC updates on arXiv.org
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An Empirical Study of Multi-Agent Collaboration for Automated Research
arXiv:2603.29632v1 Announce Type: cross Abstract: As AI agents evolve, the community is rapidly shifting from single Large Language Models (LLMs) to Multi-Agent Systems (MAS) to overcome cognitive bottlenecks in automated research. However, the optimal multi-agent coordination framework for these autonomous agents remains largely unexplored. In this paper, we present a systematic empirical study investigating the comparative efficacy of distinct multi-agent structures for automated machine lear
An Empirical Study of Multi-Agent Collaboration for Automated Research
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cs.AI, q-bio.NC updates on arXiv.org
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A Semi-amortized Lifted Learning-to-Optimize Masked (SALLO-M) Transformer Model for Scalable and Generalizable Beamforming
arXiv:2510.13077v3 Announce Type: replace-cross Abstract: We develop an unsupervised deep learning framework for real-time scalable and generalizable downlink beamforming in multi-user multiple-input single-output (MU-MISO) systems. The proposed semi-amortized lifted learning-to-optimize (SALLO) framework employs a multi-layer Transformer to iteratively refine an auxiliary variable and the beamformer solution, with a few projected gradient ascent steps at each layer. A key feature of our SALLO
A Semi-amortized Lifted Learning-to-Optimize Masked (SALLO-M) Transformer Model for Scalable and Generalizable Beamforming
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(Multiomics OR Omics) AND (Pancreatic)
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Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma
Cell Rep Med. 2026 Mar 30:102708. doi: 10.1016/j.xcrm.2026.102708. Online ahead of print.ABSTRACTIntratumor heterogeneity (ITH) undermines transcriptome-based stratification in intrahepatic cholangiocarcinoma (iCCA). Here, we integrate multi-omics data from multi-region, single-region, and single-cell RNA sequencing cohorts to systematically characterize gene expression ITH. We uncover that immune and stromal heterogeneity are primary drivers of ITH, leading to misclassification of a median 27.8
Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma
Cell Rep Med. 2026 Mar 30:102708. doi: 10.1016/j.xcrm.2026.102708. Online ahead of print.
ABSTRACT
Intratumor heterogeneity (ITH) undermines transcriptome-based stratification in intrahepatic cholangiocarcinoma (iCCA). Here, we integrate multi-omics data from multi-region, single-region, and single-cell RNA sequencing cohorts to systematically characterize gene expression ITH. We uncover that immune and stromal heterogeneity are primary drivers of ITH, leading to misclassification of a median 27.8% of tumors by existing subtyping systems. To overcome this, we identify a low-intratumor-heterogeneity/high-intertumor-variability (LIHV) gene set and develop an ITH-insensitive classification system defining five subgroups: inflammatory (SI), metabolic (SII), atypical (SIII-1), immune-silent (SIII-2), and neurodegenerative (SIII-3). These subgroups exhibit distinct clinical outcomes, molecular features, immune landscapes, and therapeutic vulnerabilities. GPRC5A and VTCN1 serve as robust immunohistochemical biomarkers for SI and SIII tumors, while serum CEA and CA19-9 identify inflammatory iCCA. Therapeutically, HSP90 inhibition synergizes with anti-PD1 in inflammatory iCCA, whereas combined anti-PD1 and anti-TIM3 suppresses neurodegenerative iCCA. Collectively, our study provides a robust molecular framework and actionable therapeutic strategies for iCCA.
PMID:41916296 | DOI:10.1016/j.xcrm.2026.102708
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npj Digital Medicine
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A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease-
MRD
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Liquid Biopsies in HNSCC: Current Landscape and Emerging Opportunities in the Era of HPV Stratification
Int J Mol Sci. 2026 Mar 20;27(6):2847. doi: 10.3390/ijms27062847.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is biologically and clinically dichotomous according to HPV status, a distinction that fundamentally dictates the design, implementation, and interpretation of liquid biopsy strategies. Conventional anatomical imaging lacks sufficient sensitivity for minimal residual disease (MRD) detection, contributing significantly to treatment failure and suboptimal clinical outcomes. This r
Liquid Biopsies in HNSCC: Current Landscape and Emerging Opportunities in the Era of HPV Stratification
Int J Mol Sci. 2026 Mar 20;27(6):2847. doi: 10.3390/ijms27062847.
ABSTRACT
Head and neck squamous cell carcinoma (HNSCC) is biologically and clinically dichotomous according to HPV status, a distinction that fundamentally dictates the design, implementation, and interpretation of liquid biopsy strategies. Conventional anatomical imaging lacks sufficient sensitivity for minimal residual disease (MRD) detection, contributing significantly to treatment failure and suboptimal clinical outcomes. This review provides a critical, evidence-based synthesis of the three principal circulating analytes, circulating tumor DNA (ctDNA), exosomes, and circulating tumor cells (CTCs), and their evolving roles in real-time, non-invasive molecular monitoring. Critically, the clinical readiness of these analytes differs substantially: while ctDNA, particularly HPV-related ctDNA, is approaching clinical validation for MRD detection and recurrence surveillance in HPV-positive HNSCC, exosomes and CTCs remain investigational tools hindered by ongoing technical challenges including lack of standardized assays, limited reproducibility across platforms, and insufficient prospective validation. We review how the presence of a clonal, virally derived DNA target in HPV-positive HNSCC contrasts with the heterogeneous somatic mutational landscape of HPV-negative tumors, necessitating divergent analytical platforms and yielding distinct clinical utility profiles for MRD detection and recurrence surveillance. We further outline a pragmatic translational pathway focused on assay standardization, particularly for exosomes and CTCs where this foundational work is most urgently needed, integration of complementary multimodal liquid biopsy approaches, and rigorously designed prospective interventional clinical trials to establish clinical utility. Collectively, these efforts aim to transition HNSCC management from reactive, anatomy-based surveillance to proactive, molecularly guided precision oncology, with the potential to improve therapeutic decision-making and patient outcomes.
PMID:41898706 | PMC:PMC13027142 | DOI:10.3390/ijms27062847
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Omics in Gastric
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Advances in Spatial Multi-Omics in Gastric Cancer
Cells. 2026 Mar 17;15(6):535. doi: 10.3390/cells15060535.ABSTRACTGastric cancer (GC) remains a major global health burden, with its unfavorable prognosis primarily driven by extensive tumor heterogeneity. Traditional bulk omics, while informative, are inherently limited by the averaging effect of diverse cell populations and fail to capture the critical spatial molecular disparities within the tumor and its microenvironment (TME). Single-cell omics can capture cellular heterogeneity but lack spa
Advances in Spatial Multi-Omics in Gastric Cancer
Cells. 2026 Mar 17;15(6):535. doi: 10.3390/cells15060535.
ABSTRACT
Gastric cancer (GC) remains a major global health burden, with its unfavorable prognosis primarily driven by extensive tumor heterogeneity. Traditional bulk omics, while informative, are inherently limited by the averaging effect of diverse cell populations and fail to capture the critical spatial molecular disparities within the tumor and its microenvironment (TME). Single-cell omics can capture cellular heterogeneity but lack spatial context. Therefore, there is an urgent clinical need for spatial multi-omics to provide a high-definition dissection of GC heterogeneity and to optimize therapeutic efficacy. This review first outlines briefly the evolution of spatial technologies, including transcriptomics, proteomics, metabolomics, genomics and epigenomics, and their transformative applications in GC research. We further explore how these platforms refine molecular classification beyond traditional models, identify next-generation biomarkers, and decode the intricate cellular interactions governing immune evasion and metastasis. Next, we highlight the pivotal role of spatial profiling in unravelling the multidimensional mechanisms of resistance to chemotherapy, targeted therapy and immunotherapy. Finally, we address current technical bottlenecks and discuss prospects for clinical translation.
PMID:41892326 | PMC:PMC13025482 | DOI:10.3390/cells15060535
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cs.AI, q-bio.NC updates on arXiv.org
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Chain-of-Authorization: Internalizing Authorization into Large Language Models via Reasoning Trajectories
arXiv:2603.22869v1 Announce Type: new Abstract: Large Language Models (LLMs) have become core cognitive components in modern artificial intelligence (AI) systems, combining internal knowledge with external context to perform complex tasks. However, LLMs typically treat all accessible data indiscriminately, lacking inherent awareness of knowledge ownership and access boundaries. This deficiency heightens risks of sensitive data leakage and adversarial manipulation, potentially enabling unauthori
Chain-of-Authorization: Internalizing Authorization into Large Language Models via Reasoning Trajectories
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cs.AI, q-bio.NC updates on arXiv.org
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Planning over MAPF Agent Dependencies via Multi-Dependency PIBT
arXiv:2603.23405v1 Announce Type: cross Abstract: Modern Multi-Agent Path Finding (MAPF) algorithms must plan for hundreds to thousands of agents in congested environments within a second, requiring highly efficient algorithms. Priority Inheritance with Backtracking (PIBT) is a popular algorithm capable of effectively planning in such situations. However, PIBT is constrained by its rule-based planning procedure and lacks generality because it restricts its search to paths that conflict with at
Planning over MAPF Agent Dependencies via Multi-Dependency PIBT
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cs.AI, q-bio.NC updates on arXiv.org
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BIRD-INTERACT: Re-imagining Text-to-SQL Evaluation for Large Language Models via Lens of Dynamic Interactions
arXiv:2510.05318v3 Announce Type: replace Abstract: Large language models (LLMs) have demonstrated remarkable performance on single-turn text-to-SQL tasks, but real-world database applications predominantly require multi-turn interactions to handle ambiguous queries, execution errors, and evolving user requirements. Existing multi-turn benchmarks fall short by treating conversation histories as static context or limiting evaluation to read-only operations, failing to reflect production-grade da
BIRD-INTERACT: Re-imagining Text-to-SQL Evaluation for Large Language Models via Lens of Dynamic Interactions
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cs.AI, q-bio.NC updates on arXiv.org
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Obscure but Effective: Classical Chinese Jailbreak Prompt Optimization via Bio-Inspired Search
arXiv:2602.22983v3 Announce Type: replace Abstract: As Large Language Models (LLMs) are increasingly used, their security risks have drawn increasing attention. Existing research reveals that LLMs are highly susceptible to jailbreak attacks, with effectiveness varying across language contexts. This paper investigates the role of classical Chinese in jailbreak attacks. Owing to its conciseness and obscurity, classical Chinese can partially bypass existing safety constraints, exposing notable vul
Obscure but Effective: Classical Chinese Jailbreak Prompt Optimization via Bio-Inspired Search
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cs.AI, q-bio.NC updates on arXiv.org
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From Context to Intent: Reasoning-Guided Function-Level Code Completion
arXiv:2508.09537v2 Announce Type: replace-cross Abstract: The growing capabilities of Large Language Models (LLMs) have led to their widespread adoption for function completion within code repositories. Recent studies on such tasks show promising results when explicit instructions, often in the form of docstrings, are available to guide the completion. However, in real-world scenarios, clear docstrings are frequently absent. Under such conditions, LLMs typically fail to produce accurate complet
From Context to Intent: Reasoning-Guided Function-Level Code Completion
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cs.AI, q-bio.NC updates on arXiv.org
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Schr\"odinger's Navigator: Imagining an Ensemble of Futures for Zero-Shot Object Navigation
arXiv:2512.21201v2 Announce Type: replace-cross Abstract: Zero-shot object navigation (ZSON) requires robots to locate target objects in unseen environments without task-specific fine-tuning or pre-built maps, a capability crucial for service and household robotics. Existing methods perform well in simulation but struggle in realistic, cluttered environments where heavy occlusions and latent hazards make large portions of the scene unobserved. These approaches typically act on a single inferred
Schr\"odinger's Navigator: Imagining an Ensemble of Futures for Zero-Shot Object Navigation
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cs.AI, q-bio.NC updates on arXiv.org
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Synthetic Data Generation for Brain-Computer Interfaces: Overview, Benchmarking, and Future Directions
arXiv:2603.12296v1 Announce Type: cross Abstract: Deep learning has achieved transformative performance across diverse domains, largely driven by the large-scale, high-quality training data. In contrast, the development of brain-computer interfaces (BCIs) is fundamentally constrained by the limited, heterogeneous, and privacy-sensitive neural recordings. Generating synthetic yet physiologically plausible brain signals has therefore emerged as a compelling way to mitigate data scarcity and enhan
Synthetic Data Generation for Brain-Computer Interfaces: Overview, Benchmarking, and Future Directions
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cs.AI, q-bio.NC updates on arXiv.org
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Seeing Eye to Eye: Enabling Cognitive Alignment Through Shared First-Person Perspective in Human-AI Collaboration
arXiv:2603.12701v1 Announce Type: cross Abstract: Despite advances in multimodal AI, current vision-based assistants often remain inefficient in collaborative tasks. We identify two key gulfs: a communication gulf, where users must translate rich parallel intentions into verbal commands due to the channel mismatch , and an understanding gulf, where AI struggles to interpret subtle embodied cues. To address these, we propose Eye2Eye, a framework that leverages first-person perspective as a chann
Seeing Eye to Eye: Enabling Cognitive Alignment Through Shared First-Person Perspective in Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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A prior information informed learning architecture for flying trajectory prediction
arXiv:2603.06863v1 Announce Type: cross Abstract: Trajectory prediction for flying objects is critical in domains ranging from sports analytics to aerospace. However, traditional methods struggle with complex physical modeling, computational inefficiencies, and high hardware demands, often neglecting critical trajectory events like landing points. This paper introduces a novel, hardware-efficient trajectory prediction framework that integrates environmental priors with a Dual-Transformer-Cascad
A prior information informed learning architecture for flying trajectory prediction
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cs.AI, q-bio.NC updates on arXiv.org
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InterReal: A Unified Physics-Based Imitation Framework for Learning Human-Object Interaction Skills
arXiv:2603.07516v1 Announce Type: cross Abstract: Interaction is one of the core abilities of humanoid robots. However, most existing frameworks focus on non-interactive whole-body control, which limits their practical applicability. In this work, we develop InterReal, a unified physics-based imitation learning framework for Real-world human-object Interaction (HOI) control. InterReal enables humanoid robots to track HOI reference motions, facilitating the learning of fine-grained interactive s