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cs.AI, q-bio.NC updates on arXiv.org
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DIAL: Decoupling Intent and Action via Latent World Modeling for End-to-End VLA
arXiv:2603.29844v1 Announce Type: cross Abstract: The development of Vision-Language-Action (VLA) models has been significantly accelerated by pre-trained Vision-Language Models (VLMs). However, most existing end-to-end VLAs treat the VLM primarily as a multimodal encoder, directly mapping vision-language features to low-level actions. This paradigm underutilizes the VLM's potential in high-level decision making and introduces training instability, frequently degrading its rich semantic represe
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Omics in Hepatocellular
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Hepatotoxicity Prediction and Multi-omics Reveal Mitochondrial and Lipid Metabolic Dysregulation in PM<sub>2.5</sub>-Induced Liver Fibrosis
Environ Health (Wash). 2025 Nov 14;4(3):513-521. doi: 10.1021/envhealth.5c00401. eCollection 2026 Mar 20.ABSTRACTProlonged exposure to fine particulate matter (PM2.5) has been linked to chronic liver injury and cancer. However, an alternative risk assessment method to prospective longitudinal studies of exposome-metabolome interactions for liver inflammation-associated hepatocellular carcinoma (HCC) is lacking. This study investigates the risk of long-term real-world PM2.5 exposure in hepatocarc
Hepatotoxicity Prediction and Multi-omics Reveal Mitochondrial and Lipid Metabolic Dysregulation in PM<sub>2.5</sub>-Induced Liver Fibrosis
Environ Health (Wash). 2025 Nov 14;4(3):513-521. doi: 10.1021/envhealth.5c00401. eCollection 2026 Mar 20.
ABSTRACT
Prolonged exposure to fine particulate matter (PM2.5) has been linked to chronic liver injury and cancer. However, an alternative risk assessment method to prospective longitudinal studies of exposome-metabolome interactions for liver inflammation-associated hepatocellular carcinoma (HCC) is lacking. This study investigates the risk of long-term real-world PM2.5 exposure in hepatocarcinogenesis through machine learning techniques. Shotgun mass spectrometry (MS) imaging data were acquired from mouse models across a continuum of fibrosis, cirrhosis, and HCC for training a multiclass classification model to identify "No Risk", "Cancer Risk", and "Cancer". Direct infusion-MS data from PM2.5-exposed mouse livers were analyzed to classify risk. By integrating data-driven and knowledge-based approaches, 14 disease progression biomarkers were identified for modeling. Our results suggest that chronic real-world PM2.5 exposure can induce liver fibrosis, presenting cancer risk. Incorporating metabolomics, lipidomics, and transcriptomics, we propose PM2.5 exposure induces mitochondrial dysfunction, activates AMPK signaling, and increases ceramide accumulation, potentially mediating insulin resistance that contributes to nonalcoholic fatty liver disease and HCC progression. This work represents a significant advancement in assessing hepatotoxicity of environmental toxicants by reducing reliance on traditional animal testing methods. It also underscores the potential of emerging technologies in transforming our understanding of PM2.5 exposure, paving the way for targeted interventions.
PMID:41883379 | PMC:PMC13010293 | DOI:10.1021/envhealth.5c00401
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Nature - Issue - nature.com science feeds
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Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Nature, Published online: 24 March 2026; doi:10.1038/s41586-026-10403-zAuthor Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Nature, Published online: 24 March 2026; doi:10.1038/s41586-026-10403-z
Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis-
cs.AI, q-bio.NC updates on arXiv.org
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AOI: Turning Failed Trajectories into Training Signals for Autonomous Cloud Diagnosis
arXiv:2603.03378v1 Announce Type: cross Abstract: Large language model (LLM) agents offer a promising data-driven approach to automating Site Reliability Engineering (SRE), yet their enterprise deployment is constrained by three challenges: restricted access to proprietary data, unsafe action execution under permission-governed environments, and the inability of closed systems to improve from failures. We present AOI (Autonomous Operations Intelligence), a trainable multi-agent framework formul
AOI: Turning Failed Trajectories into Training Signals for Autonomous Cloud Diagnosis
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cs.AI, q-bio.NC updates on arXiv.org
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Chat-Based Support Alone May Not Be Enough: Comparing Conversational and Embedded LLM Feedback for Mathematical Proof Learning
arXiv:2602.18807v1 Announce Type: cross Abstract: We evaluate GPTutor, an LLM-powered tutoring system for an undergraduate discrete mathematics course. It integrates two LLM-supported tools: a structured proof-review tool that provides embedded feedback on students' written proof attempts, and a chatbot for math questions. In a staggered-access study with 148 students, earlier access was associated with higher homework performance during the interval when only the experimental group could use t
Chat-Based Support Alone May Not Be Enough: Comparing Conversational and Embedded LLM Feedback for Mathematical Proof Learning
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cs.AI, q-bio.NC updates on arXiv.org
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To Reason or Not to: Selective Chain-of-Thought in Medical Question Answering
arXiv:2602.20130v1 Announce Type: cross Abstract: Objective: To improve the efficiency of medical question answering (MedQA) with large language models (LLMs) by avoiding unnecessary reasoning while maintaining accuracy. Methods: We propose Selective Chain-of-Thought (Selective CoT), an inference-time strategy that first predicts whether a question requires reasoning and generates a rationale only when needed. Two open-source LLMs (Llama-3.1-8B and Qwen-2.5-7B) were evaluated on four biomedic
To Reason or Not to: Selective Chain-of-Thought in Medical Question Answering
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cs.AI, q-bio.NC updates on arXiv.org
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Emotion-LLaMAv2 and MMEVerse: A New Framework and Benchmark for Multimodal Emotion Understanding
arXiv:2601.16449v2 Announce Type: replace-cross Abstract: Understanding human emotions from multimodal signals poses a significant challenge in affective computing and human-robot interaction. While multimodal large language models (MLLMs) have excelled in general vision-language tasks, their capabilities in emotional reasoning remain limited. The field currently suffers from a scarcity of large-scale datasets with high-quality, descriptive emotion annotations and lacks standardized benchmarks
Emotion-LLaMAv2 and MMEVerse: A New Framework and Benchmark for Multimodal Emotion Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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ALOE: Action-Level Off-Policy Evaluation for Vision-Language-Action Model Post-Training
arXiv:2602.12691v2 Announce Type: replace-cross Abstract: We study how to improve large foundation vision-language-action (VLA) systems through online reinforcement learning (RL) in real-world settings. Central to this process is the value function, which provides learning signals to guide VLA learning from experience. In practice, the value function is estimated from trajectory fragments collected from different data sources, including historical policies and intermittent human interventions.