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PromptForge-350k: A Large-Scale Dataset and Contrastive Framework for Prompt-Based AI Image Forgery Localization

arXiv:2603.29386v1 Announce Type: cross Abstract: The rapid democratization of prompt-based AI image editing has recently exacerbated the risks associated with malicious content fabrication and misinformation. However, forgery localization methods targeting these emerging editing techniques remain significantly under-explored. To bridge this gap, we first introduce a fully automated mask annotating framework that leverages keypoint alignment and semantic space similarity to generate precise ground-truth masks for edited regions. Based on this framework, we construct PromptForge-350k, a large-scale forgery localization dataset covering four state-of-the-art prompt-based AI image editing models, thereby mitigating the data scarcity in this domain. Furthermore, we propose ICL-Net, an effective forgery localization network featuring a triple-stream backbone and intra-image contrastive learning. This design enables the model to capture highly robust and generalizable forensic features. Extensive experiments demonstrate that our method achieves an IoU of 62.5% on PromptForge-350k, outperforming SOTA methods by 5.1%. Additionally, it exhibits strong robustness against common degradations with an IoU drop of less than 1%, and shows promising generalization capabilities on unseen editing models, achieving an average IoU of 41.5%.
  • βœ‡Omics In Lung
  • Tumorigenesis and Tumor Microenvironment in Lung Cancer Puneet Dhillon Β· Moshe Carroll Β· Haiying Cheng
    Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.ABSTRACTLung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic i
     

Tumorigenesis and Tumor Microenvironment in Lung Cancer

28 March 2026 at 18:00

Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.

ABSTRACT

Lung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic injury from tobacco smoke, airway disease, and treatment itself remodels local tissue programs that can either support antitumor immunity or promote immune exclusion, fibrosis, and metastatic seeding. Here, we analyze recent evidence linking lung tumorigenesis to TME ecology across histologies, with emphasis on CAF heterogeneity, spatial organization of immune niches, and the distinct microenvironments that govern organ-specific metastasis (including brain metastasis). We also evaluate emerging therapeutic strategies that aim to target or reprogram the TME, including perioperative immune checkpoint blockade, combined immunotherapy-radiotherapy approaches, and pathways such as IL-6 and TGF-Ξ² that coordinate immune suppression and stromal remodeling. Finally, we outline key gaps and potential future directions, such as longitudinal and spatial multi-omics, better biomarkers of stromal state, and trial designs that account for dynamic microenvironmental adaptation.

PMID:41899399 | PMC:PMC13025777 | DOI:10.3390/cimb48030247

Motion Dreamer: Boundary Conditional Motion Reasoning for Physically Coherent Video Generation

arXiv:2412.00547v4 Announce Type: replace-cross Abstract: Recent advances in video generation have shown promise for generating future scenarios, critical for planning and control in autonomous driving and embodied intelligence. However, real-world applications demand more than visually plausible predictions; they require reasoning about object motions based on explicitly defined boundary conditions, such as initial scene image and partial object motion. We term this capability Boundary Conditional Motion Reasoning. Current approaches either neglect explicit user-defined motion constraints, producing physically inconsistent motions, or conversely demand complete motion inputs, which are rarely available in practice. Here we introduce Motion Dreamer, a two-stage framework that explicitly separates motion reasoning from visual synthesis, addressing these limitations. Our approach introduces instance flow, a sparse-to-dense motion representation enabling effective integration of partial user-defined motions, and the motion inpainting strategy to robustly enable reasoning motions of other objects. Extensive experiments demonstrate that Motion Dreamer significantly outperforms existing methods, achieving superior motion plausibility and visual realism, thus bridging the gap towards practical boundary conditional motion reasoning. Our webpage is available: https://envision-research.github.io/MotionDreamer/.

ObjChangeVR: Object State Change Reasoning from Continuous Egocentric Views in VR Environments

arXiv:2603.06648v1 Announce Type: cross Abstract: Recent advances in multimodal large language models (MLLMs) offer a promising approach for natural language-based scene change queries in virtual reality (VR). Prior work on applying MLLMs for object state understanding has focused on egocentric videos that capture the camera wearer's interactions with objects. However, object state changes may occur in the background without direct user interaction, lacking explicit motion cues and making them difficult to detect. Moreover, no benchmark exists for evaluating this challenging scenario. To address these challenges, we introduce ObjChangeVR-Dataset, specifically for benchmarking the question-answering task of object state change. We also propose ObjChangeVR, a framework that combines viewpoint-aware and temporal-based retrieval to identify relevant frames, along with cross-view reasoning that reconciles inconsistent evidence from multiple viewpoints. Extensive experiments demonstrate that ObjChangeVR significantly outperforms baseline approaches across multiple MLLMs.

Making Slow Thinking Faster: Compressing LLM Chain-of-Thought via Step Entropy

arXiv:2508.03346v2 Announce Type: replace Abstract: Large Language Models (LLMs) using Chain-of-Thought (CoT) prompting excel at complex reasoning but generate verbose thought processes with considerable redundancy, leading to increased inference costs and reduced efficiency. We introduce a novel CoT compression framework based on step entropy, a metric that quantifies \emph{the informational contribution of individual reasoning steps} to identify redundancy. Through theoretical analysis and extensive empirical validation on mathematical reasoning benchmarks, we demonstrate that steps with low entropy are indeed highly redundant. Our experiments reveal that an astonishing 80\% of low-entropy intermediate steps can be pruned with minor degradation in the final answer accuracy across DeepSeek-R1-7B, 14B and Qwen3-8B. This finding sharply contrasts with random or high-entropy pruning, which severely impairs reasoning performance. Building on this, we propose a novel two-stage training strategy combining Supervised Fine-Tuning (SFT) and Group Relative Policy Optimization (GRPO) reinforcement learning. This approach enables LLMs to autonomously learn to generate compressed COTs during inference by strategically incorporating [SKIP] tokens. Our method significantly improves LLM inference efficiency while preserving accuracy, paving the way for more scalable LLM deployments and a better understanding of their internal reasoning. The code and data are released in https://github.com/staymylove/COT_Compresstion_via_Step_entropy.
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