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cs.AI, q-bio.NC updates on arXiv.org
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PromptForge-350k: A Large-Scale Dataset and Contrastive Framework for Prompt-Based AI Image Forgery Localization
arXiv:2603.29386v1 Announce Type: cross Abstract: The rapid democratization of prompt-based AI image editing has recently exacerbated the risks associated with malicious content fabrication and misinformation. However, forgery localization methods targeting these emerging editing techniques remain significantly under-explored. To bridge this gap, we first introduce a fully automated mask annotating framework that leverages keypoint alignment and semantic space similarity to generate precise gro
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Omics In Lung
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Tumorigenesis and Tumor Microenvironment in Lung Cancer
Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.ABSTRACTLung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic i
Tumorigenesis and Tumor Microenvironment in Lung Cancer
Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.
ABSTRACT
Lung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic injury from tobacco smoke, airway disease, and treatment itself remodels local tissue programs that can either support antitumor immunity or promote immune exclusion, fibrosis, and metastatic seeding. Here, we analyze recent evidence linking lung tumorigenesis to TME ecology across histologies, with emphasis on CAF heterogeneity, spatial organization of immune niches, and the distinct microenvironments that govern organ-specific metastasis (including brain metastasis). We also evaluate emerging therapeutic strategies that aim to target or reprogram the TME, including perioperative immune checkpoint blockade, combined immunotherapy-radiotherapy approaches, and pathways such as IL-6 and TGF-Ξ² that coordinate immune suppression and stromal remodeling. Finally, we outline key gaps and potential future directions, such as longitudinal and spatial multi-omics, better biomarkers of stromal state, and trial designs that account for dynamic microenvironmental adaptation.
PMID:41899399 | PMC:PMC13025777 | DOI:10.3390/cimb48030247
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cs.AI, q-bio.NC updates on arXiv.org
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Motion Dreamer: Boundary Conditional Motion Reasoning for Physically Coherent Video Generation
arXiv:2412.00547v4 Announce Type: replace-cross Abstract: Recent advances in video generation have shown promise for generating future scenarios, critical for planning and control in autonomous driving and embodied intelligence. However, real-world applications demand more than visually plausible predictions; they require reasoning about object motions based on explicitly defined boundary conditions, such as initial scene image and partial object motion. We term this capability Boundary Conditi
Motion Dreamer: Boundary Conditional Motion Reasoning for Physically Coherent Video Generation
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cs.AI, q-bio.NC updates on arXiv.org
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ObjChangeVR: Object State Change Reasoning from Continuous Egocentric Views in VR Environments
arXiv:2603.06648v1 Announce Type: cross Abstract: Recent advances in multimodal large language models (MLLMs) offer a promising approach for natural language-based scene change queries in virtual reality (VR). Prior work on applying MLLMs for object state understanding has focused on egocentric videos that capture the camera wearer's interactions with objects. However, object state changes may occur in the background without direct user interaction, lacking explicit motion cues and making them
ObjChangeVR: Object State Change Reasoning from Continuous Egocentric Views in VR Environments
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cs.AI, q-bio.NC updates on arXiv.org
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Making Slow Thinking Faster: Compressing LLM Chain-of-Thought via Step Entropy
arXiv:2508.03346v2 Announce Type: replace Abstract: Large Language Models (LLMs) using Chain-of-Thought (CoT) prompting excel at complex reasoning but generate verbose thought processes with considerable redundancy, leading to increased inference costs and reduced efficiency. We introduce a novel CoT compression framework based on step entropy, a metric that quantifies \emph{the informational contribution of individual reasoning steps} to identify redundancy. Through theoretical analysis and ex