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TechCrunch
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Anthropic ramps up its political activities with a new PAC
With the midterms right around the corner, the new group is positioned to back candidates who support the AI company's policy agenda.
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TechCrunch
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The Facebook insider building content moderation for the AI era
Moonbounce has raised $12 million to grow its AI control engine that converts content moderation policies into consistent, predictable AI behavior.
The Facebook insider building content moderation for the AI era
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MRD
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Liquid biopsies using circulating tumor DNA for surveillance of gastrointestinal cancers in Hispanics: first real-world data report
ESMO Real World Data Digit Oncol. 2026 Jan 14;11:100652. doi: 10.1016/j.esmorw.2025.100652. eCollection 2026 Mar.ABSTRACTBACKGROUND: Malignant tumors release circulating tumor DNA (ctDNA) into the bloodstream, providing insights into tumor-specific mutations and pathways driving cancer progression. ctDNA testing is currently approved as a type of liquid biopsy to monitor disease burden and detect minimal residual disease (MRD). This study aimed to evaluate the adoption of ctDNA testing in a comm
Liquid biopsies using circulating tumor DNA for surveillance of gastrointestinal cancers in Hispanics: first real-world data report
ESMO Real World Data Digit Oncol. 2026 Jan 14;11:100652. doi: 10.1016/j.esmorw.2025.100652. eCollection 2026 Mar.
ABSTRACT
BACKGROUND: Malignant tumors release circulating tumor DNA (ctDNA) into the bloodstream, providing insights into tumor-specific mutations and pathways driving cancer progression. ctDNA testing is currently approved as a type of liquid biopsy to monitor disease burden and detect minimal residual disease (MRD). This study aimed to evaluate the adoption of ctDNA testing in a community oncology practice and assess the overall diagnostic performance of ctDNA and its association with disease progression in stage IV colorectal cancer (CRC), as determined by imaging studies.
PATIENTS AND METHODS: This retrospective study analyzed the medical records of 88 patients with gastrointestinal cancers (80 CRC, 5 gastric, 3 esophageal) who underwent ctDNA molecular testing between January 2020 and April 2022. Electronic medical records from patients aged β₯21 years who had two or more ctDNA tests with concurrent imaging studies or a pathology-confirmed CRC, gastric cancer, or esophageal cancer diagnosis were evaluated.
RESULTS: At baseline, 47 (53.4%) patients had negative and 41 (46.6%) had positive results. Most patients had CRC (90.1%). In stage IV CRC, ctDNA was increasing before radiologic progression in all documented cases (100%), with a median lead time of 2.5 months (range 0.5-15 months). In early-stage CRC (I-III), ctDNA preceded radiologic progression in 40% of cases, with a median lead time of 6 months (range 6-10 months).
CONCLUSIONS: Using real-world data, we report the first-time results of the ctDNA testing adoption in a community oncology setting among patients with gastrointestinal cancers, predominantly CRC. Our findings suggest that integration of ctDNA testing may support disease monitoring in routine clinical practice.
PMID:41930304 | PMC:PMC13040887 | DOI:10.1016/j.esmorw.2025.100652
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InfoQ

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Presentation: Panel: Taking Architecture Out of the Echo Chamber
Andrew Harmel-Law and a panel of expert architects discuss the shifting practice of architecture in 2025. They explain strategies for communicating technical debt to stakeholders, the benefits of decentralized decision-making through ADRs, and the career paths of modern leaders. The panel shares insights on bridging the gap between mobile and backend teams to ensure a holistic system. By Andrew Harmel-Law, Cat Morris, Diana Montalion, Shana Dacres-Lawrence, Vanessa Formicola, Elena Stojmilova, P
Presentation: Panel: Taking Architecture Out of the Echo Chamber
Andrew Harmel-Law and a panel of expert architects discuss the shifting practice of architecture in 2025. They explain strategies for communicating technical debt to stakeholders, the benefits of decentralized decision-making through ADRs, and the career paths of modern leaders. The panel shares insights on bridging the gap between mobile and backend teams to ensure a holistic system.
By Andrew Harmel-Law, Cat Morris, Diana Montalion, Shana Dacres-Lawrence, Vanessa Formicola, Elena Stojmilova, Peter Hunter-
cs.AI, q-bio.NC updates on arXiv.org
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Analysis of LLM Performance on AWS Bedrock: Receipt-item Categorisation Case Study
arXiv:2604.01615v1 Announce Type: new Abstract: This paper presents a systematic, cost-aware evaluation of large language models (LLMs) for receipt-item categorisation within a production-oriented classification framework. We compare four instruction-tuned models available through AWS Bedrock: Claude 3.7 Sonnet, Claude 4 Sonnet, Mixtral 8x7B Instruct, and Mistral 7B Instruct. The aim of the study was (1) to assess performance across accuracy, response stability, and token-level cost, and (2) to
Analysis of LLM Performance on AWS Bedrock: Receipt-item Categorisation Case Study
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cs.AI, q-bio.NC updates on arXiv.org
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ThinknCheck: Grounded Claim Verification with Compact, Reasoning-Driven, and Interpretable Models
arXiv:2604.01652v1 Announce Type: new Abstract: We present ThinknCheck, a 1B-parameter verifier for grounded claim verification that first produces a short, structured rationale and then a binary verdict. We construct LLMAggreFact-Think, a 24.1k reasoning-augmented training set derived from LLMAggreFact, and fine-tune a 4-bit Gemma3 model to follow this format. On LLMAggreFact, ThinknCheck attains 78.1 balanced accuracy (BAcc), surpassing MiniCheck-7B (77.4) with 7x fewer parameters; removing t
ThinknCheck: Grounded Claim Verification with Compact, Reasoning-Driven, and Interpretable Models
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cs.AI, q-bio.NC updates on arXiv.org
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CORAL: Towards Autonomous Multi-Agent Evolution for Open-Ended Discovery
arXiv:2604.01658v1 Announce Type: new Abstract: Large language model (LLM)-based evolution is a promising approach for open-ended discovery, where progress requires sustained search and knowledge accumulation. Existing methods still rely heavily on fixed heuristics and hard-coded exploration rules, which limit the autonomy of LLM agents. We present CORAL, the first framework for autonomous multi-agent evolution on open-ended problems. CORAL replaces rigid control with long-running agents that e
CORAL: Towards Autonomous Multi-Agent Evolution for Open-Ended Discovery
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cs.AI, q-bio.NC updates on arXiv.org
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Retrieval-aligned Tabular Foundation Models Enable Robust Clinical Risk Prediction in Electronic Health Records Under Real-world Constraints
arXiv:2604.01841v1 Announce Type: new Abstract: Clinical prediction from structured electronic health records (EHRs) is challenging due to high dimensionality, heterogeneity, class imbalance, and distribution shift. While tabular in-context learning (TICL) and retrieval-augmented methods perform well on generic benchmarks, their behavior in clinical settings remains unclear. We present a multi-cohort EHR benchmark comparing classical, deep tabular, and TICL models across varying data scale, fea
Retrieval-aligned Tabular Foundation Models Enable Robust Clinical Risk Prediction in Electronic Health Records Under Real-world Constraints
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cs.AI, q-bio.NC updates on arXiv.org
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The Latent Space: Foundation, Evolution, Mechanism, Ability, and Outlook
arXiv:2604.02029v1 Announce Type: new Abstract: Latent space is rapidly emerging as a native substrate for language-based models. While modern systems are still commonly understood through explicit token-level generation, an increasing body of work shows that many critical internal processes are more naturally carried out in continuous latent space than in human-readable verbal traces. This shift is driven by the structural limitations of explicit-space computation, including linguistic redunda
The Latent Space: Foundation, Evolution, Mechanism, Ability, and Outlook
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cs.AI, q-bio.NC updates on arXiv.org
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Quantifying Self-Preservation Bias in Large Language Models
arXiv:2604.02174v1 Announce Type: new Abstract: Instrumental convergence predicts that sufficiently advanced AI agents will resist shutdown, yet current safety training (RLHF) may obscure this risk by teaching models to deny self-preservation motives. We introduce the \emph{Two-role Benchmark for Self-Preservation} (TBSP), which detects misalignment through logical inconsistency rather than stated intent by tasking models to arbitrate identical software-upgrade scenarios under counterfactual ro
Quantifying Self-Preservation Bias in Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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When to ASK: Uncertainty-Gated Language Assistance for Reinforcement Learning
arXiv:2604.02226v1 Announce Type: new Abstract: Reinforcement learning (RL) agents often struggle with out-of-distribution (OOD) scenarios, leading to high uncertainty and random behavior. While language models (LMs) contain valuable world knowledge, larger ones incur high computational costs, hindering real-time use, and exhibit limitations in autonomous planning. We introduce Adaptive Safety through Knowledge (ASK), which combines smaller LMs with trained RL policies to enhance OOD generaliza
When to ASK: Uncertainty-Gated Language Assistance for Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Preference learning in shades of gray: Interpretable and bias-aware reward modeling for human preferences
arXiv:2604.01312v1 Announce Type: cross Abstract: Learning human preferences in language models remains fundamentally challenging, as reward modeling relies on subtle, subjective comparisons or shades of gray rather than clear-cut labels. This study investigates the limits of current approaches and proposes a feature-augmented framework to better capture the multidimensional nature of human judgment. Using the Anthropic HHRLHF dataset, we evaluate ten diverse large language models LLMs under a
Preference learning in shades of gray: Interpretable and bias-aware reward modeling for human preferences
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cs.AI, q-bio.NC updates on arXiv.org
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Semantically Annotated Multimodal Dataset for RF Interpretation and Prediction
arXiv:2604.01433v1 Announce Type: cross Abstract: Current limitations in wireless modeling and radio frequency (RF)-based AI are primarily driven by a lack of high-quality, measurement-based datasets that connect RF signals to their physical environments. RF heatmaps, the typical form of such data, are high-dimensional and complex but lack the geometric and semantic context needed for interpretation, constraining the development of supervised machine learning models. To address this bottleneck,
Semantically Annotated Multimodal Dataset for RF Interpretation and Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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RefinementEngine: Automating Intent-to-Device Filtering Policy Deployment under Network Constraints
arXiv:2604.01627v1 Announce Type: cross Abstract: Translating security intent into deployable network enforcement rules and maintaining their effectiveness despite evolving cyber threats remains a largely manual process in most Security Operations Centers (SOCs). In large and heterogeneous networks, this challenge is complicated by topology-dependent reachability constraints and device-specific security control capabilities, making the process slow, error-prone, and a recurring source of miscon
RefinementEngine: Automating Intent-to-Device Filtering Policy Deployment under Network Constraints
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cs.AI, q-bio.NC updates on arXiv.org
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Robust Embodied Perception in Dynamic Environments via Disentangled Weight Fusion
arXiv:2604.01669v1 Announce Type: cross Abstract: Embodied perception systems face severe challenges of dynamic environment distribution drift when they continuously interact in open physical spaces. However, the existing domain incremental awareness methods often rely on the domain id obtained in advance during the testing phase, which limits their practicability in unknown interaction scenarios. At the same time, the model often overfits to the context-specific perceptual noise, which leads t
Robust Embodied Perception in Dynamic Environments via Disentangled Weight Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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OpenGo: An OpenClaw-Based Robotic Dog with Real-Time Skill Switching
arXiv:2604.01708v1 Announce Type: cross Abstract: Adaptation to complex tasks and multiple scenarios remains a significant challenge for a single robot agent. The ability to acquire organize, and switch between a wide range of skills in real time, particularly in dynamic environments, has become a fundamental requirement for embodied intelligence. We introduce OpenGo, an OpenClaw-powered embodied robotic dog capable of switching skills in real time according to the scene and task instructions.
OpenGo: An OpenClaw-Based Robotic Dog with Real-Time Skill Switching
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cs.AI, q-bio.NC updates on arXiv.org
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LiveMathematicianBench: A Live Benchmark for Mathematician-Level Reasoning with Proof Sketches
arXiv:2604.01754v1 Announce Type: cross Abstract: Mathematical reasoning is a hallmark of human intelligence, and whether large language models (LLMs) can meaningfully perform it remains a central question in artificial intelligence and cognitive science. As LLMs are increasingly integrated into scientific workflows, rigorous evaluation of their mathematical capabilities becomes a practical necessity. Existing benchmarks are limited by synthetic settings and data contamination. We present LiveM
LiveMathematicianBench: A Live Benchmark for Mathematician-Level Reasoning with Proof Sketches
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cs.AI, q-bio.NC updates on arXiv.org
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A deep learning pipeline for PAM50 subtype classification using histopathology images and multi-objective patch selection
arXiv:2604.01798v1 Announce Type: cross Abstract: Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment strategies. In this study, we introduce a novel optimization-driven deep learning framework that aims to reduce reliance on costly molecular assays by directly predicting PAM50 subtypes from H&E-stained whole-sli
A deep learning pipeline for PAM50 subtype classification using histopathology images and multi-objective patch selection
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cs.AI, q-bio.NC updates on arXiv.org
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Reliable News or Propagandist News? A Neurosymbolic Model Using Genre, Topic, and Persuasion Techniques to Improve Robustness in Classification
arXiv:2604.01936v1 Announce Type: cross Abstract: Among news disorders, propagandist news are particularly insidious, because they tend to mix oriented messages with factual reports intended to look like reliable news. To detect propaganda, extant approaches based on Language Models such as BERT are promising but often overfit their training datasets, due to biases in data collection. To enhance classification robustness and improve generalization to new sources, we propose a neurosymbolic appr
Reliable News or Propagandist News? A Neurosymbolic Model Using Genre, Topic, and Persuasion Techniques to Improve Robustness in Classification
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cs.AI, q-bio.NC updates on arXiv.org
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Rare-Aware Autoencoding: Reconstructing Spatially Imbalanced Data
arXiv:2604.02031v1 Announce Type: cross Abstract: Autoencoders can be challenged by spatially non-uniform sampling of image content. This is common in medical imaging, biology, and physics, where informative patterns occur rarely at specific image coordinates, as background dominates these locations in most samples, biasing reconstructions toward the majority appearance. In practice, autoencoders are biased toward dominant patterns resulting in the loss of fine-grained detail and causing blurre