Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Background: Telemedicine has expanded rapidly in recent years, with particularly pronounced growth following the COVID-19 pandemic. By improving access to care and offering greater flexibility in service delivery, it has become an important component of health care. Although the benefits of telemedicine for patients are well documented, its effects on physician job satisfaction remain insufficiently understood. Given the importance of job satisfaction for workforce stability, physician well-being, and quality of care, further examination of how telemedicine affects physician job satisfaction is warranted. Objective: This study aims to examine the association between telemedicine adoption and physician job satisfaction and to assess whether the physician-patient relationship mediates this association. Methods: A cross-sectional survey was conducted among health care professionals in Xi’an, China. Data were collected between November 7 and December 8, 2023, via an online questionnaire administered using the REDCap (Research Electronic Data Capture; Vanderbilt University) platform. A total of 12,052 physicians were included in the analysis. Physician job satisfaction was measured using a validated 6-point Likert scale. Telemedicine adoption was assessed through self-report. A partial proportional odds model was used to examine the association between telemedicine adoption and job satisfaction, adjusting for a comprehensive set of potential confounders. Additionally, the Karlson-Holm-Breen (KHB) decomposition method was used to explore the mediating role of physician-patient relationship quality in this association. Results: Among 12,052 surveyed physicians, 1642 (13.62%) reported adopting telemedicine, whereas 10,410 (86.38%) did not. After adjusting for demographic characteristics, work-related factors, psychological factors, and physician-patient relationship, telemedicine adoption was significantly associated with higher job satisfaction (odds ratio [OR] 1.17, 95% CI 1.05‐1.30). Findings were robust across multiple sensitivity analyses. Subgroup analyses indicated that the association did not vary across physician subgroups, and no significant interaction effects were observed. Mediation analysis revealed a total effect of telemedicine on job satisfaction of 0.33 (95% CI 0.17‐0.50), with an indirect effect of 0.10 (95% CI 0.07‐0.13) through improved physician-patient relationships, accounting for 30.30% of the total effect. Conclusions: These findings suggest that telemedicine adoption is positively associated with physician job satisfaction, partially mediated by the physician-patient relationship. Policies should promote telemedicine adoption while prioritizing platform designs that support effective physician-patient interactions to enhance provider well-being and care outcomes.

arXiv:2602.02050v3 Announce Type: replace Abstract: Tool-using agents based on Large Language Models (LLMs) excel in tasks such as mathematical reasoning and multi-hop question answering. However, in long trajectories, agents often trigger excessive and low-quality tool calls, increasing latency and degrading inference performance, making managing tool-use behavior challenging. In this work, we conduct entropy-based pilot experiments and observe a strong positive correlation between entropy reduction and high-quality tool calls. Building on this finding, we propose using entropy reduction as a supervisory signal and design two reward strategies to address the differing needs of optimizing tool-use behavior. Sparse outcome rewards provide coarse, trajectory-level guidance to improve efficiency, while dense process rewards offer fine-grained supervision to enhance performance. Experiments across diverse domains show that both reward designs improve tool-use behavior: the former reduces tool calls by 72.07% compared to the average of baselines, while the latter improves performance by 22.27%. These results position entropy reduction as a key mechanism for enhancing tool-use behavior, enabling agents to be more adaptive in real-world applications.

arXiv:2602.07023v2 Announce Type: replace-cross Abstract: Recent works have increasingly applied Large Language Models (LLMs) as agents in financial stock market simulations to test if micro-level behaviors aggregate into macro-level phenomena. However, a crucial question arises: Do LLM agents' behaviors align with real market participants? This alignment is key to the validity of simulation results. To explore this, we select a financial stock market scenario to test behavioral consistency. Investors are typically classified as fundamental or technical traders, but most simulations fix strategies at initialization, failing to reflect real-world trading dynamics. In this work, we assess whether agents' strategy switching aligns with financial theory, providing a framework for this evaluation. We operationalize four behavioral-finance drivers-loss aversion, herding, wealth differentiation, and price misalignment-as personality traits set via prompting and stored long-term. In year-long simulations, agents process daily price-volume data, trade under a designated style, and reassess their strategy every 10 trading days. We introduce four alignment metrics and use Mann-Whitney U tests to compare agents' style-switching behavior with financial theory. Our results show that recent LLMs' switching behavior is only partially consistent with behavioral-finance theories, highlighting the need for further refinement in aligning agent behavior with financial theory.

arXiv:2603.12290v1 Announce Type: cross Abstract: Scholarly web is a vast network of knowledge connected by citations. However, this system is increasingly compromised by miscitation, where references do not support or even contradict the claims they are cited for. Current miscitation detection methods, which primarily rely on semantic similarity or network anomalies, struggle to capture the nuanced relationship between a citation's context and its place in the wider network. While large language models (LLMs) offer powerful capabilities in semantic reasoning for this task, their deployment is hindered by hallucination risks and high computational costs. In this work, we introduce LLM-Augmented Graph Learning-based Miscitation Detector (LAGMiD), a novel framework that leverages LLMs for deep semantic reasoning over citation graphs and distills this knowledge into graph neural networks (GNNs) for efficient and scalable miscitation detection. Specifically, LAGMiD introduces an evidence-chain reasoning mechanism, which uses chain-of-thought prompting, to perform multi-hop citation tracing and assess semantic fidelity. To reduce LLM inference costs, we design a knowledge distillation method aligning GNN embeddings with intermediate LLM reasoning states. A collaborative learning strategy further routes complex cases to the LLM while optimizing the GNN for structure-based generalization. Experiments on three real-world benchmarks show that LAGMiD achieves state-of-the-art miscitation detection with significantly reduced inference cost.

Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9

A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.

arXiv:2603.08034v1 Announce Type: cross Abstract: Emotion recognition in real-world environments is hindered by partial occlusions, missing modalities, and severe class imbalance. To address these issues, particularly for the Affective Behavior Analysis in-the-wild (ABAW) Expression challenge, we propose a multimodal framework that dynamically fuses visual and audio representations. Our approach uses a dual-branch Transformer architecture featuring a safe cross-attention mechanism and a modality dropout strategy. This design allows the network to rely on audio-based predictions when visual cues are absent. To mitigate the long-tail distribution of the Aff-Wild2 dataset, we apply focal loss optimization, combined with a sliding-window soft voting strategy to capture dynamic emotional transitions and reduce frame-level classification jitter. Experiments demonstrate that our framework effectively handles missing modalities and complex spatiotemporal dependencies, achieving an accuracy of 60.79% and an F1-score of 0.5029 on the Aff-Wild2 validation set.

arXiv:2509.15237v2 Announce Type: replace Abstract: Industrial workflows demand adaptive and trustworthy assistance that can operate under limited computing, connectivity, and strict privacy constraints. In this work, we present MICA (Multi-Agent Industrial Coordination Assistant), a perception-grounded and speech-interactive system that delivers real-time guidance for assembly, troubleshooting, part queries, and maintenance. MICA coordinates five role-specialized language agents, audited by a safety checker, to ensure accurate and compliant support. To achieve robust step understanding, we introduce Adaptive Step Fusion (ASF), which dynamically blends expert reasoning with online adaptation from natural speech feedback. Furthermore, we establish a new multi-agent coordination benchmark across representative task categories and propose evaluation metrics tailored to industrial assistance, enabling systematic comparison of different coordination topologies. Our experiments demonstrate that MICA consistently improves task success, reliability, and responsiveness over baseline structures, while remaining deployable on practical offline hardware. Together, these contributions highlight MICA as a step toward deployable, privacy-preserving multi-agent assistants for dynamic factory environments. The source code will be made publicly available at https://github.com/Kratos-Wen/MICA.

arXiv:2602.14010v1 Announce Type: cross Abstract: Pathology foundation models (PFMs) have enabled robust generalization in computational pathology through large-scale datasets and expansive architectures, but their substantial computational cost, particularly for gigapixel whole slide images, limits clinical accessibility and scalability. Here, we present LitePath, a deployment-friendly foundational framework designed to mitigate model over-parameterization and patch level redundancy. LitePath integrates LiteFM, a compact model distilled from three large PFMs (Virchow2, H-Optimus-1 and UNI2) using 190 million patches, and the Adaptive Patch Selector (APS), a lightweight component for task-specific patch selection. The framework reduces model parameters by 28x and lowers FLOPs by 403.5x relative to Virchow2, enabling deployment on low-power edge hardware such as the NVIDIA Jetson Orin Nano Super. On this device, LitePath processes 208 slides per hour, 104.5x faster than Virchow2, and consumes 0.36 kWh per 3,000 slides, 171x lower than Virchow2 on an RTX3090 GPU. We validated accuracy using 37 cohorts across four organs and 26 tasks (26 internal, 9 external, and 2 prospective), comprising 15,672 slides from 9,808 patients disjoint from the pretraining data. LitePath ranks second among 19 evaluated models and outperforms larger models including H-Optimus-1, mSTAR, UNI2 and GPFM, while retaining 99.71% of the AUC of Virchow2 on average. To quantify the balance between accuracy and efficiency, we propose the Deployability Score (D-Score), defined as the weighted geometric mean of normalized AUC and normalized FLOP, where LitePath achieves the highest value, surpassing Virchow2 by 10.64%. These results demonstrate that LitePath enables rapid, cost-effective and energy-efficient pathology image analysis on accessible hardware while maintaining accuracy comparable to state-of-the-art PFMs and reducing the carbon footprint of AI deployment.