Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Grounded Token Initialization for New Vocabulary in LMs for Generative Recommendation
arXiv:2604.02324v1 Announce Type: cross Abstract: Language models (LMs) are increasingly extended with new learnable vocabulary tokens for domain-specific tasks, such as Semantic-ID tokens in generative recommendation. The standard practice initializes these new tokens as the mean of existing vocabulary embeddings, then relies on supervised fine-tuning to learn their representations. We present a systematic analysis of this strategy: through spectral and geometric diagnostics, we show that mean
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cs.AI, q-bio.NC updates on arXiv.org
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AI Co-Scientist for Ranking: Discovering Novel Search Ranking Models alongside LLM-based AI Agents with Cloud Computing Access
arXiv:2603.22376v1 Announce Type: cross Abstract: Recent advances in AI agents for software engineering and scientific discovery have demonstrated remarkable capabilities, yet their application to developing novel ranking models in commercial search engines remains unexplored. In this paper, we present an AI Co-Scientist framework that automates the full search ranking research pipeline: from idea generation to code implementation and GPU training job scheduling with expert in the loop. Our app
AI Co-Scientist for Ranking: Discovering Novel Search Ranking Models alongside LLM-based AI Agents with Cloud Computing Access
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Omics in Gastric
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Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer
Gastric Cancer. 2026 Mar 13. doi: 10.1007/s10120-026-01718-x. Online ahead of print.ABSTRACTBACKGROUND: 5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.METHODS: We integrated clinical specimen analysis, in vitro
Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer
Gastric Cancer. 2026 Mar 13. doi: 10.1007/s10120-026-01718-x. Online ahead of print.
ABSTRACT
BACKGROUND: 5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.
METHODS: We integrated clinical specimen analysis, in vitro and in vivo functional assays, multi-omics profiling, and molecular docking to delineate the role of the mitochondrial oxidoreductase OXNAD1 in mediating 5-FU resistance in gastric cancer, and to assess the therapeutic potential of the natural polyphenol resveratrol as a chemosensitizing agent.
RESULTS: OXNAD1 was found to be significantly overexpressed in gastric cancer tissues and cell lines, correlating with unfavorable prognosis and enhanced 5-FU resistance. Mechanistically, OXNAD1 directly bound to and suppressed the ferroptosis driver PTGS2, thereby attenuating lipid peroxidation and mitochondrial damage, ultimately restraining ferroptosis and promoting drug resistance. Notably, resveratrol disrupted the OXNAD1-PTGS2 interaction by directly binding OXNAD1, reinstating ferroptotic activity, markedly enhancing the cytotoxic effect of 5-FU in resistant cells, and potentiating the antitumor efficacy of 5-FU in xenograft models.
CONCLUSION: The OXNAD1-PTGS2 axis constitutes a critical metabolic-cell death cross-regulatory pathway underlying 5-FU resistance in gastric cancer. Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance.
PMID:41824193 | DOI:10.1007/s10120-026-01718-x
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cs.AI, q-bio.NC updates on arXiv.org
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CoCo: Code as CoT for Text-to-Image Preview and Rare Concept Generation
arXiv:2603.08652v1 Announce Type: new Abstract: Recent advancements in Unified Multimodal Models (UMMs) have significantly advanced text-to-image (T2I) generation, particularly through the integration of Chain-of-Thought (CoT) reasoning. However, existing CoT-based T2I methods largely rely on abstract natural-language planning, which lacks the precision required for complex spatial layouts, structured visual elements, and dense textual content. In this work, we propose CoCo (Code-as-CoT), a cod
CoCo: Code as CoT for Text-to-Image Preview and Rare Concept Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Language in the Flow of Time: Time-Series-Paired Texts Weaved into a Unified Temporal Narrative
arXiv:2502.08942v3 Announce Type: replace-cross Abstract: While many advances in time series models focus exclusively on numerical data, research on multimodal time series, particularly those involving contextual textual information, remains in its infancy. With recent progress in large language models and time series learning, we revisit the integration of paired texts with time series through the Platonic Representation Hypothesis, which posits that representations of different modalities con
Language in the Flow of Time: Time-Series-Paired Texts Weaved into a Unified Temporal Narrative
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cs.AI, q-bio.NC updates on arXiv.org
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NutriOrion: A Hierarchical Multi-Agent Framework for Personalized Nutrition Intervention Grounded in Clinical Guidelines
arXiv:2602.18650v1 Announce Type: cross Abstract: Personalized nutrition intervention for patients with multimorbidity is critical for improving health outcomes, yet remains challenging because it requires the simultaneous integration of heterogeneous clinical conditions, medications, and dietary guidelines. Single-agent large language models (LLMs) often suffer from context overload and attention dilution when processing such high-dimensional patient profiles. We introduce NutriOrion, a hierar
NutriOrion: A Hierarchical Multi-Agent Framework for Personalized Nutrition Intervention Grounded in Clinical Guidelines
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cs.AI, q-bio.NC updates on arXiv.org
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Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction
Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
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cs.AI, q-bio.NC updates on arXiv.org
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Virne: A Comprehensive Benchmark for RL-based Network Resource Allocation in NFV
arXiv:2507.19234v2 Announce Type: replace-cross Abstract: Resource allocation (RA) is critical to efficient service deployment in Network Function Virtualization (NFV), a transformative networking paradigm. Recently, deep Reinforcement Learning (RL)-based methods have been showing promising potential to address this complexity. However, the lack of a systematic benchmarking framework and thorough analysis hinders the exploration of emerging networks and the development of more robust algorithms