Madelyn Olson discusses the evolution of Valkey's data structures, moving away from "textbook" pointer-chasing HashMaps to more cache-aware designs. She explains the implementation of "Swedish" tables to maximize memory density. She shares insights on systems intuition, memory prefetching, and the rigorous testing needed for mission-critical caches.

In a move that will grow its oncology pipeline, Gilead Sciences is spending more than $3 billion to buy the German biotech Tubulis, the companies said Tuesday.

The deal includes an upfront payment of $3.15 billion and up to $1.85 billion more if certain milestones are reached. It also highlights both the therapeutic and commercial promise of antibody-drug conjugates, the next-generation chemotherapy treatments that the privately held Tubulis is developing.

Gilead’s latest move comes just months after it said it would acquire Arcellx in a deal worth $7.8 billion. The two companies had already been working together on a multiple myeloma CAR-T therapy that could be approved later this year. Gilead last month also announced that it was buying Ouro Therapeutics, which is focused on drugs for autoimmune disease, for up to $2.18 billion.

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This article walks you through the Go implementation of Bloom filters to optimize the performance of a recommender. It cover the architectural view, Bloom filter mechanics, Go integration, parameter tuning, and practical lessons learned from making it work under production constraints.

An abdominal aortic aneurysm is a life-threatening vascular condition with limited treatment options. 

Now, researchers from the University of Michigan Frankel Cardiovascular Center have identified a driving force behind the condition, opening up a potential target for new therapies. Their paper uncovering the causal link between triglycerides and abdominal aortic aneurysms won the STAT Madness 2026 popular vote. 

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WASHINGTON — The Food and Drug Administration used the president’s budget to propose policies aimed at encouraging domestic development and manufacturing of drugs.  

FDA Commissioner Marty Makary has said the agency needs “giant, big ideas” to counter China’s dominance in early-stage clinical development of drugs. Among the FDA’s ideas are proposals to make it easier to run early-stage trials in the U.S. and to hand an advantage to U.S.-based generics manufacturers.

The Trump administration has been using a variety of policy levers to try and bring drug manufacturing to the U.S. For example, many of the brand drugmakers that struck deals to lower U.S. prices also promised to increase domestic manufacturing, under the threat of tariffs.

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Anthropic's Claude Code CLI had its full TypeScript source exposed after a source map file was accidentally included in version 2.1.88 of its npm package. The 512,000-line codebase was archived to GitHub within hours. Anthropic called it a packaging error caused by human error. The leak revealed unreleased features, internal model codenames, and multi-agent orchestration architecture.

Designed to manage concurrent agents running in containers across local and remote compute, Scion is an experimental orchestration testbed that enables developers to run groups of specialized agents with isolated identities, credentials, and shared workspaces.

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Today’s the day

By law, the 2027 Medicare Advantage payment regulation must come out today. It will set the tone for how the Trump administration wants to work with the health insurance industry: as the “new sheriff in town” or just another friendly regulator.

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Pinterest Engineering cut Apache Spark out-of-memory failures by 96% using improved observability, configuration tuning, and automatic memory retries. Staged rollout, dashboards, and proactive memory adjustments stabilized data pipelines, reduced manual intervention, and lowered operational overhead across tens of thousands of daily jobs.

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A four-month FDA delay prompted a cash-strapped biotech company to shutter. The White House’s proposed NIH cuts are drawing bipartisan backlash. Peptide hype is outpacing evidence. And more!

The need-to-know this morning

• Neurocrine Biosciences said this morning that it would buy Soleno Therapeutics and its treatment for Prader-Willi syndrome for $2.9 billion. Neurocrine is paying $53 a share for Soleno, a 34% premium to its closing price on Thursday.
  

A four-month FDA delay derailed a small biotech. Is it a sign of the times?

FDA delays can happen. For large drugmakers, they can be frustrating; for small drugmakers, they can be existential.

Continue to STAT+ to read the full story…

How can you focus in a sea of results from a large regression test suite? This article describes a stochastic approach that relies on some degree of redundancy in your CI regression test set. This approach does not guarantee you will catch every bug every time, but it gives you your best bet of not missing the subtle signatures of all the bugs uncovered by your CI regression test suite runs.

A 600-run benchmark by Ruby committer Yusuke Endoh tested Claude Code across 13 languages, implementing a simplified Git. Ruby, Python, and JavaScript were the fastest and cheapest, at $0.36- $0.39 per run. Statistically typed languages cost 1.4-2.6x more. Adding type checkers to dynamic languages imposed 1.6-3.2x slowdowns. Full dataset available on GitHub.

This week's Java roundup for March 30th, 2026, features news highlighting: the GA release of TornadoVM 4.0 and Google ADK for Java 1.0; first release candidates of Grails and Gradle; maintenance releases of Micronaut, Apache Tomcart and Apache Log4j; and an update on Jakarta EE 12.

Anthropic introduces a three-agent harness separating planning, generation, and evaluation to improve long-running autonomous AI workflows for frontend and full-stack development. Industry commentary highlights structured approaches, iterative evaluation, and practical methods to maintain coherence and quality over multi-hour AI coding sessions.

TigerFS is a new experimental filesystem that mounts a database as a directory and stores files directly in PostgreSQL. The open source project exposes database data through a standard filesystem interface, allowing developers and AI agents to interact with it using common Unix tools such as ls, cat, find, and grep, rather than via APIs or SDKs.

Swift 6.3 advances Swift cross-platform story with official Android support, improves significantly C interoperability through the new @c attribute, and continues extending embedded programming support. It also strengthens the ecosystem with a unified build system direction and gives developers more low-level performance control.

Module Federation 2.0, an open-source micro-frontend mechanism introduced with webpack 5, offers significant updates including dynamic TypeScript type hints, decoupled runtime layers, and Node.js support. It enhances compatibility across various bundlers and frameworks. Key features include a Side Effect Scanner and easier integration for remote modules, addressing previous adoption challenges.

The article discusses the challenges faced during a migration from a relational database to NoSQL, focusing on the importance of database sequences for unique identifiers. It outlines the development of a new sequence service using DynamoDB and a two-tier caching architecture.

GitHub has launched a continuous AI-powered workflow to manage accessibility feedback at scale. Using GitHub Actions, Copilot, and Models APIs, the system centralizes reports, analyzes WCAG compliance, and automates triage while maintaining human validation. Teams now resolve feedback faster, improving inclusion and cross-functional collaboration.

On March 31, 2026, two versions of the Axios library were compromised and found to contain a Remote Access Trojan. The malicious packages were published through a hijacked maintainer account. The Axios team is investigating how the breach occurred and has deprecated the affected versions. Security experts emphasize the need for better dependency management.