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Enhancing AI-Based Tropical Cyclone Track and Intensity Forecasting via Systematic Bias Correction

arXiv:2603.22314v1 Announce Type: cross Abstract: Tropical cyclones (TCs) pose severe threats to life, infrastructure, and economies in tropical and subtropical regions, underscoring the critical need for accurate and timely forecasts of both track and intensity. Recent advances in AI-based weather forecasting have shown promise in improving TC track forecasts. However, these systems are typically trained on coarse-resolution reanalysis data (e.g., ERA5 at 0.25 degree), which constrains predicted TC positions to a fixed grid and introduces significant discretization errors. Moreover, intensity forecasting remains limited especially for strong TCs by the smoothing effect of coarse meteorological fields and the use of regression losses that bias predictions toward conditional means. To address these limitations, we propose BaguanCyclone, a novel, unified framework that integrates two key innovations: (1) a probabilistic center refinement module that models the continuous spatial distribution of TC centers, enabling finer track precision; and (2) a region-aware intensity forecasting module that leverages high-resolution internal representations within dynamically defined sub-grid zones around the TC core to better capture localized extremes. Evaluated on the global IBTrACS dataset across six major TC basins, our system consistently outperforms both operational numerical weather prediction (NWP) models and most AI-based baselines, delivering a substantial enhancement in forecast accuracy. Remarkably, BaguanCyclone excels in navigating meteorological complexities, consistently delivering accurate forecasts for re-intensification, sweeping arcs, twin cyclones, and meandering events. Our code is available at https://github.com/DAMO-DI-ML/Baguan-cyclone.

Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy

11 March 2026 at 18:00

Genes Immun. 2026 Mar 10. doi: 10.1038/s41435-026-00382-6. Online ahead of print.

ABSTRACT

The prognosis for hepatocellular carcinoma remains grim. Combining radiotherapy with immune checkpoint blockade (ICB) has shown potential to enhance therapeutic outcomes, yet there is a pressing need for further advancements. Our previous research demonstrated that this combined approach suppresses ALKBH5 gene expression and increases m6A modification levels in hepatocellular carcinoma tissues. High-throughput sequencing and detailed molecular analysis revealed that inhibiting ALKBH5 amplifies CIITA m6A modifications post-therapy. This modulation triggers MHC II molecule expression in tumors, facilitating the presentation of tumor-associated antigens to CD4 + T lymphocytes and the recruitment of CD8 + T cells for an anti-tumor immune response. Building on these findings, we engineered a CIITA vector with a specific site mutation to confirm that the regulation of CIITA by the combined radiotherapy and immunotherapy is mediated through m6A methylation. Consequently, we established a comprehensive network involving ALKBH5, CIITA, MHC II, and CD4+ and CD8 + T cells. To elucidate the role and underlying molecular mechanisms of this combined therapy in reshaping the tumor immune microenvironment for hepatocellular carcinoma, we employed multi-omics approaches across in vitro, animal model, and clinical multi-dimensional studies, offering novel insights for enhancing treatment efficacy.

PMID:41807814 | DOI:10.1038/s41435-026-00382-6

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