Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Uncertainty as a Planning Signal: Multi-Turn Decision Making for Goal-Oriented Conversation
arXiv:2604.03924v1 Announce Type: cross Abstract: Goal-oriented conversational systems require making sequential decisions under uncertainty about the user's intent, where the algorithm must balance information acquisition and target commitment over multiple turns. Existing approaches address this challenge from different perspectives: structured methods enable multi-step planning but rely on predefined schemas, while LLM-based approaches support flexible interactions but lack long-horizon deci
-
Omics In Lung
-
Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages
Pathogens. 2026 Feb 27;15(3):254. doi: 10.3390/pathogens15030254.ABSTRACTPulmonary tuberculosis (TB) remains a major global health challenge. The molecular and metabolic responses of monocyte-derived macrophages (MDMs), which are critical for host defense against Mycobacterium tuberculosis (Mtb), are not fully characterized. A murine pulmonary TB model was established by intravenous injection of BALB/c mice with the attenuated Mtb strain H37Ra; controls received saline. After 8 weeks, lung MDMs
Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages
Pathogens. 2026 Feb 27;15(3):254. doi: 10.3390/pathogens15030254.
ABSTRACT
Pulmonary tuberculosis (TB) remains a major global health challenge. The molecular and metabolic responses of monocyte-derived macrophages (MDMs), which are critical for host defense against Mycobacterium tuberculosis (Mtb), are not fully characterized. A murine pulmonary TB model was established by intravenous injection of BALB/c mice with the attenuated Mtb strain H37Ra; controls received saline. After 8 weeks, lung MDMs were isolated for integrated transcriptomic and untargeted metabolomic profiling. Transcriptomic analysis identified 3970 differentially expressed genes (DEGs) in infected MDMs, including upregulated Ptpn1, Dgat2, and Alox5ap and downregulated Cyld, Zfp61, and Mapk11. Metabolomic profiling revealed 113 differentially accumulated metabolites (DAMs). Taurocholic acid and linoleic acid were identified as potential diagnostic biomarkers, both achieving an area under the curve (AUC) of 1.0 in ROC analysis. Integrated omics analysis showed a positive correlation between linoleic acid levels and the expression of Tbxas1, Acaa1b, and Acox1, implicating lipid metabolic pathways in the host response to TB. This multi-omics study delineates key molecular and metabolic alterations in lung MDMs during TB infection. The identified metabolites, taurocholic acid and linoleic acid, show promise as biomarkers, while dysregulated linoleic acid metabolism represents a potential target for novel diagnostic and therapeutic strategies against TB.
PMID:41901707 | PMC:PMC13029415 | DOI:10.3390/pathogens15030254
-
cs.AI, q-bio.NC updates on arXiv.org
-
Set-Valued Prediction for Large Language Models with Feasibility-Aware Coverage Guarantees
arXiv:2603.22966v1 Announce Type: cross Abstract: Large language models (LLMs) inherently operate over a large generation space, yet conventional usage typically reports the most likely generation (MLG) as a point prediction, which underestimates the model's capability: although the top-ranked response can be incorrect, valid answers may still exist within the broader output space and can potentially be discovered through repeated sampling. This observation motivates moving from point predictio
Set-Valued Prediction for Large Language Models with Feasibility-Aware Coverage Guarantees
-
cs.AI, q-bio.NC updates on arXiv.org
-
Retrieval-Augmented Generation with Covariate Time Series
arXiv:2603.04951v2 Announce Type: replace Abstract: While RAG has greatly enhanced LLMs, extending this paradigm to Time-Series Foundation Models (TSFMs) remains a challenge. This is exemplified in the Predictive Maintenance of the Pressure Regulating and Shut-Off Valve (PRSOV), a high-stakes industrial scenario characterized by (1) data scarcity, (2) short transient sequences, and (3) covariate coupled dynamics. Unfortunately, existing time-series RAG approaches predominantly rely on generated
Retrieval-Augmented Generation with Covariate Time Series
-
Nature - Issue - nature.com science feeds
-
Functional hierarchy of the human neocortex across the lifespan
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10219-xfMRI data from individuals of a wide range of ages (from a few days to 100 years old) are used to map the key organizational axes of functional connectivity in the human cortex throughout the lifespan.
Functional hierarchy of the human neocortex across the lifespan
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10219-x
fMRI data from individuals of a wide range of ages (from a few days to 100 years old) are used to map the key organizational axes of functional connectivity in the human cortex throughout the lifespan.-
cs.AI, q-bio.NC updates on arXiv.org
-
An Embedding-based Approach to Inconsistency-tolerant Reasoning with Inconsistent Ontologies
arXiv:2304.01664v3 Announce Type: replace Abstract: Inconsistency handling is an important issue in knowledge management. Especially in ontology engineering, logical inconsistencies may occur during ontology construction. A natural way to reason with an inconsistent ontology is to utilize the maximal consistent subsets of the ontology. However, previous studies on selecting maximum consistent subsets have rarely considered the semantics of the axioms, which may result in irrational inference. I
An Embedding-based Approach to Inconsistency-tolerant Reasoning with Inconsistent Ontologies
-
cs.AI, q-bio.NC updates on arXiv.org
-
Proximity-Based Multi-Turn Optimization: Practical Credit Assignment for LLM Agent Training
arXiv:2602.19225v1 Announce Type: new Abstract: Multi-turn LLM agents are becoming pivotal to production systems, spanning customer service automation, e-commerce assistance, and interactive task management, where accurately distinguishing high-value informative signals from stochastic noise is critical for sample-efficient training. In real-world scenarios, a failure in a trivial task may reflect random instability, whereas success in a high-difficulty task signifies a genuine capability break
Proximity-Based Multi-Turn Optimization: Practical Credit Assignment for LLM Agent Training
-
cs.AI, q-bio.NC updates on arXiv.org
-
How to Allocate, How to Learn? Dynamic Rollout Allocation and Advantage Modulation for Policy Optimization
arXiv:2602.19208v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) has proven effective for Large Language Model (LLM) reasoning, yet current methods face key challenges in resource allocation and policy optimization dynamics: (i) uniform rollout allocation ignores gradient variance heterogeneity across problems, and (ii) the softmax policy structure causes gradient attenuation for high-confidence correct actions, while excessive gradient updates may destabi
How to Allocate, How to Learn? Dynamic Rollout Allocation and Advantage Modulation for Policy Optimization
-
cs.AI, q-bio.NC updates on arXiv.org
-
VideoMind: A Chain-of-LoRA Agent for Temporal-Grounded Video Reasoning
arXiv:2503.13444v3 Announce Type: replace-cross Abstract: Videos, with their unique temporal dimension, demand precise grounded understanding, where answers are directly linked to visual, interpretable evidence. Despite significant breakthroughs in text-based reasoning with large language models, multi-modal reasoning - especially for videos - remains limited. In this work, we fill this gap by introducing VideoMind, a novel video-language agent for temporal-grounded video reasoning. Our method