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Journal of Medical Internet Research
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Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial
Background: Social media intervention may enhance HIV prevention among men who have sex with men, but the effect of this intervention in resource-limited settings remains unclear. Objective: This randomized controlled trial evaluated whether a social media intervention grounded in the information-motivation-behavioral skills (IMB) model could be beneficial for HIV prevention among men who have sex with men in resource-limited settings. Methods: Participants were recruited in Nanning, China, betw
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cs.AI, q-bio.NC updates on arXiv.org
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VitaTouch: Property-Aware Vision-Tactile-Language Model for Robotic Quality Inspection in Manufacturing
arXiv:2604.03322v1 Announce Type: cross Abstract: Quality inspection in smart manufacturing requires identifying intrinsic material and surface properties beyond visible geometry, yet vision-only methods remain vulnerable to occlusion and reflection. We propose VitaTouch, a property-aware vision-tactile-language model for material-property inference and natural-language attribute description. VitaTouch uses modality-specific encoders and a dual Q-Former to extract language-relevant visual and t
VitaTouch: Property-Aware Vision-Tactile-Language Model for Robotic Quality Inspection in Manufacturing
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cs.AI, q-bio.NC updates on arXiv.org
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CoopGuard: Stateful Cooperative Agents Safeguarding LLMs Against Evolving Multi-Round Attacks
arXiv:2604.04060v1 Announce Type: cross Abstract: As Large Language Models (LLMs) are increasingly deployed in complex applications, their vulnerability to adversarial attacks raises urgent safety concerns, especially those evolving over multi-round interactions. Existing defenses are largely reactive and struggle to adapt as adversaries refine strategies across rounds. In this work, we propose CoopGuard , a stateful multi-round LLM defense framework based on cooperative agents that maintains a
CoopGuard: Stateful Cooperative Agents Safeguarding LLMs Against Evolving Multi-Round Attacks
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cs.AI, q-bio.NC updates on arXiv.org
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
arXiv:2502.13388v3 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a ke
Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
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cs.AI, q-bio.NC updates on arXiv.org
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ReFlow: Self-correction Motion Learning for Dynamic Scene Reconstruction
arXiv:2604.01561v1 Announce Type: cross Abstract: We present ReFlow, a unified framework for monocular dynamic scene reconstruction that learns 3D motion in a novel self-correction manner from raw video. Existing methods often suffer from incomplete scene initialization for dynamic regions, leading to unstable reconstruction and motion estimation, which often resorts to external dense motion guidance such as pre-computed optical flow to further stabilize and constrain the reconstruction of dyna
ReFlow: Self-correction Motion Learning for Dynamic Scene Reconstruction
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cs.AI, q-bio.NC updates on arXiv.org
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
arXiv:2502.13388v2 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a ke
Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
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cs.AI, q-bio.NC updates on arXiv.org
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Generation Is Compression: Zero-Shot Video Coding via Stochastic Rectified Flow
arXiv:2603.26571v2 Announce Type: replace-cross Abstract: Recent advances in generative modeling have enabled perceptual video compression at ultra-low bitrates, yet existing methods predominantly treat the generative model as a refinement or reconstruction module attached to a separately designed codec backbone. We propose \emph{Generative Video Codebook Codec} (GVCC), a zero-shot framework that turns a pretrained video generative model into the codec itself: the transmitted bitstream directly
Generation Is Compression: Zero-Shot Video Coding via Stochastic Rectified Flow
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Cell
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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
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Cell
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Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
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cs.AI, q-bio.NC updates on arXiv.org
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PSPA-Bench: A Personalized Benchmark for Smartphone GUI Agent
arXiv:2603.29318v1 Announce Type: new Abstract: Smartphone GUI agents execute tasks by operating directly on app interfaces, offering a path to broad capability without deep system integration. However, real-world smartphone use is highly personalized: users adopt diverse workflows and preferences, challenging agents to deliver customized assistance rather than generic solutions. Existing GUI agent benchmarks cannot adequately capture this personalization dimension due to sparse user-specific d
PSPA-Bench: A Personalized Benchmark for Smartphone GUI Agent
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cs.AI, q-bio.NC updates on arXiv.org
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FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
arXiv:2603.29557v1 Announce Type: new Abstract: Scientific idea generation (SIG) is critical to AI-driven autonomous research, yet existing approaches are often constrained by a static retrieval-then-generation paradigm, leading to homogeneous and insufficiently divergent ideas. In this work, we propose FlowPIE, a tightly coupled retrieval-generation framework that treats literature exploration and idea generation as a co-evolving process. FlowPIE expands literature trajectories via a flow-guid
FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
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cs.AI, q-bio.NC updates on arXiv.org
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iPoster: Content-Aware Layout Generation for Interactive Poster Design via Graph-Enhanced Diffusion Models
arXiv:2603.29469v1 Announce Type: cross Abstract: We present iPoster, an interactive layout generation framework that empowers users to guide content-aware poster layout design by specifying flexible constraints. iPoster enables users to specify partial intentions within the intention module, such as element categories, sizes, positions, or coarse initial drafts. Then, the generation module instantly generates refined, context-sensitive layouts that faithfully respect these constraints. iPoster
iPoster: Content-Aware Layout Generation for Interactive Poster Design via Graph-Enhanced Diffusion Models
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cs.AI, q-bio.NC updates on arXiv.org
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Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Samplin
Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
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Nature - Issue - nature.com science feeds
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Gene regulatory landscape dissected by single-cell four-omics sequencing
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-zCombining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.
Gene regulatory landscape dissected by single-cell four-omics sequencing
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z
Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.-
Omics in Gastric
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Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Aging Dis. 2026 Mar 19. doi: 10.14336/AD.2025.1571. Online ahead of print.ABSTRACTGastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide, with poor prognosis for advanced-stage patients. Therefore, in-depth exploration of the mechanisms underlying GC initiation and progression, as well as the development of novel therapeutic strategies, is of crucial importance. Cellular senescence is a stable cell cycle arrest program that plays a dual role in GC. It exe
Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Aging Dis. 2026 Mar 19. doi: 10.14336/AD.2025.1571. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide, with poor prognosis for advanced-stage patients. Therefore, in-depth exploration of the mechanisms underlying GC initiation and progression, as well as the development of novel therapeutic strategies, is of crucial importance. Cellular senescence is a stable cell cycle arrest program that plays a dual role in GC. It exerts tumor-suppressive effects via growth arrest but also promotes tumor progression and immune evasion by remodeling the tumor microenvironment (TME) through senescence-associated secretory phenotype (SASP). This review comprehensively elucidates the molecular mechanisms of cellular senescence in GC and the core regulatory networks involving gene regulation, epigenetic modifications, metabolic reprogramming, and cell cycle arrest. Additionally, the review highlights how senescent cells foster an immunosuppressive microenvironment via SASP, forming a self-reinforcing feed-forward loop. Regarding therapeutic strategies, we summarize potential approaches targeting cellular senescence, including senescence induction, senescent cell clearance, SASP modulation, and multi-target synergistic therapy by integrating epigenetic regulation, metabolic intervention, and immune microenvironment modulation. Despite progress, numerous challenges remain. Future studies should leverage multi-omics technologies, novel models' development, and large-scale clinical trials to advance the clinical translation of GC cellular senescence research, providing new insights for improving prognosis.
PMID:41910653 | DOI:10.14336/AD.2025.1571
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cs.AI, q-bio.NC updates on arXiv.org
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WIST: Web-Grounded Iterative Self-Play Tree for Domain-Targeted Reasoning Improvement
arXiv:2603.22352v1 Announce Type: cross Abstract: Recent progress in reinforcement learning with verifiable rewards (RLVR) offers a practical path to self-improvement of language models, but existing methods face a key trade-off: endogenous self-play can drift over iterations, while corpus-grounded approaches rely on curated data environments. We present \textbf{WIST}, a \textbf{W}eb-grounded \textbf{I}terative \textbf{S}elf-play \textbf{T}ree framework for domain-targeted reasoning improvement
WIST: Web-Grounded Iterative Self-Play Tree for Domain-Targeted Reasoning Improvement
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cs.AI, q-bio.NC updates on arXiv.org
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Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation
arXiv:2603.12793v1 Announce Type: cross Abstract: A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly optimize within a shared feature space. In this work, we present Cheers, a unified multimodal model that decouples patch-level details from semantic representations, thereby stabilizing semantics for multimod
Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation
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cs.AI, q-bio.NC updates on arXiv.org
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LatentChem: From Textual CoT to Latent Thinking in Chemical Reasoning
arXiv:2602.07075v4 Announce Type: replace-cross Abstract: Chemical large language models (LLMs) predominantly rely on explicit Chain-of-Thought (CoT) in natural language to perform complex reasoning. However, chemical reasoning is inherently continuous and structural, and forcing it into discrete linguistic tokens introduces a fundamental representation mismatch that constrains both efficiency and performance. We introduce LatentChem, a latent reasoning interface that decouples chemical computa
LatentChem: From Textual CoT to Latent Thinking in Chemical Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Evo: Autoregressive-Diffusion Large Language Models with Evolving Balance
arXiv:2603.06617v1 Announce Type: cross Abstract: We introduce \textbf{Evo}, a duality latent trajectory model that bridges autoregressive (AR) and diffusion-based language generation within a continuous evolutionary generative framework. Rather than treating AR decoding and diffusion generation as separate paradigms, Evo reconceptualizes text generation as a latent flow: each token is associated with a vector-valued embedding that evolves over a progression variable $t_i \in [0, 1]$, indicatin
Evo: Autoregressive-Diffusion Large Language Models with Evolving Balance
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cs.AI, q-bio.NC updates on arXiv.org
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SketchGraphNet: A Memory-Efficient Hybrid Graph Transformer for Large-Scale Sketch Corpora Recognition
arXiv:2603.07521v1 Announce Type: cross Abstract: This work investigates large-scale sketch recognition from a graph-native perspective, where free-hand sketches are directly modeled as structured graphs rather than raster images or stroke sequences. We propose SketchGraphNet, a hybrid graph neural architecture that integrates local message passing with a memory-efficient global attention mechanism, without relying on auxiliary positional or structural encodings. To support systematic evaluatio