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cs.AI, q-bio.NC updates on arXiv.org
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AeroTherm-GPT: A Verification-Centered LLM Framework for Thermal Protection System Engineering Workflows
arXiv:2604.01738v1 Announce Type: new Abstract: Integrating Large Language Models (LLMs) into hypersonic thermal protection system (TPS) design is bottlenecked by cascading constraint violations when generating executable simulation artifacts. General-purpose LLMs, treating generation as single-pass text completion, fail to satisfy the sequential, multi-gate constraints inherent in safety-critical engineering workflows. To address this, we propose AeroTherm-GPT, the first TPS-specialized LLM Ag
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cs.AI, q-bio.NC updates on arXiv.org
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No Attacker Needed: Unintentional Cross-User Contamination in Shared-State LLM Agents
arXiv:2604.01350v1 Announce Type: cross Abstract: LLM-based agents increasingly operate across repeated sessions, maintaining task states to ensure continuity. In many deployments, a single agent serves multiple users within a team or organization, reusing a shared knowledge layer across user identities. This shared persistence expands the failure surface: information that is locally valid for one user can silently degrade another user's outcome when the agent reapplies it without regard for sc
No Attacker Needed: Unintentional Cross-User Contamination in Shared-State LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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PRISM: Robust VLM Alignment with Principled Reasoning for Integrated Safety in Multimodality
arXiv:2508.18649v2 Announce Type: replace-cross Abstract: Safeguarding vision-language models (VLMs) is a critical challenge, as existing methods often suffer from over-defense, which harms utility, or rely on shallow alignment, failing to detect complex threats that require deep reasoning. To this end, we introduc PRISM (Principled Reasoning for Integrated Safety in Multimodality), a System 2-like framework that aligns VLMs through a structured four-stage reasoning process explicitly designed
PRISM: Robust VLM Alignment with Principled Reasoning for Integrated Safety in Multimodality
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cs.AI, q-bio.NC updates on arXiv.org
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When Only the Final Text Survives: Implicit Execution Tracing for Multi-Agent Attribution
arXiv:2603.17445v3 Announce Type: replace Abstract: When a multi-agent system produces an incorrect or harmful answer, who is accountable if execution logs and agent identifiers are unavailable? In practice, generated content is often detached from its execution environment due to privacy or system boundaries, leaving the final text as the only auditable artifact. Existing attribution methods rely on full execution traces and thus become ineffective in such metadata-deprived settings. We propos
When Only the Final Text Survives: Implicit Execution Tracing for Multi-Agent Attribution
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Omics in Hepatocellular
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Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation
Molecules. 2026 Mar 16;31(6):997. doi: 10.3390/molecules31060997.ABSTRACTCONTEXT: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that mediates the ubiquitination of cell cycle regulators. Curcumol, a sesquiterpene natural product, has been reported to regulate SKP2-mediated ubiquitination degradation to overcome drug resistance in cancer cells. However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mecha
Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation
Molecules. 2026 Mar 16;31(6):997. doi: 10.3390/molecules31060997.
ABSTRACT
CONTEXT: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that mediates the ubiquitination of cell cycle regulators. Curcumol, a sesquiterpene natural product, has been reported to regulate SKP2-mediated ubiquitination degradation to overcome drug resistance in cancer cells. However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mechanisms are still unclear.
OBJECTIVE: To investigate the role of SKP2 in curcumol-induced cell cycle arrest and its underlying mechanisms.
MATERIALS AND METHODS: Transcriptomic and proteomic analyses were used to screen the ubiquitination-related factors in curcumol treated hepatocellular carcinoma cells. Lentiviral overexpression, co-immunoprecipitation assays, ubiquitination analysis, and cell-line-derived xenograft (CDX) models were used to dissect the role and mechanisms of the identified ubiquitination-related factor in the cell cycle arrest effect of curcucmol.
RESULTS: Curcumol modulated the expression of CDK4, CDK6, Cyclin D1, p27 and SKP2. SKP2 was one candidate target of curcumol selected by multi-omics. Overexpressed SKP2 partially reversed curcumol-induced growth inhibition and G1-phase arrest. The increased expression of p27 induced by curcumol was attenuated by overexpressed SKP2. Curcumol impaired the interaction between SKP2 and p27, and led to the ubiquitination and degradation of p27. In vivo, curcumol effectively reduced tumor growth, and its antitumor effect was significantly mitigated by SKP2 overexpression.
DISCUSSION AND CONCLUSIONS: Curcumol reduced SKP2 expression, weakened the interaction between SKP2 and p27, inhibited degradation of p27, and then induced G1 phase cell-cycle arrest in SK-Hep-1 cells.
PMID:41900096 | PMC:PMC13029316 | DOI:10.3390/molecules31060997
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Audit: A Security Analysis System for LLM Agent Applications
arXiv:2603.22853v1 Announce Type: cross Abstract: What should a developer inspect before deploying an LLM agent: the model, the tool code, the deployment configuration, or all three? In practice, many security failures in agent systems arise not from model weights alone, but from the surrounding software stack: tool functions that pass untrusted inputs to dangerous operations, exposed credentials in deployment artifacts, and over-privileged Model Context Protocol (MCP) configurations. We pres
Agent Audit: A Security Analysis System for LLM Agent Applications
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cs.AI, q-bio.NC updates on arXiv.org
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GameVerse: Can Vision-Language Models Learn from Video-based Reflection?
arXiv:2603.06656v1 Announce Type: cross Abstract: Human gameplay is a visually grounded interaction loop in which players act, reflect on failures, and watch tutorials to refine strategies. Can Vision-Language Models (VLMs) also learn from video-based reflection? We present GameVerse, a comprehensive video game benchmark that enables a reflective visual interaction loop. Moving beyond traditional fire-and-forget evaluations, it uses a novel reflect-and-retry paradigm to assess how VLMs internal
GameVerse: Can Vision-Language Models Learn from Video-based Reflection?
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cs.AI, q-bio.NC updates on arXiv.org
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Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation
arXiv:2603.03864v1 Announce Type: new Abstract: While EEG features differentiate Major Depressive Disorder (MDD) from healthy controls (HC), their clinical utility as biomarkers depends on a monotonic trajectory across the disease spectrum, from the acute (AC) phase to the maintenance (MA) phase and finally to the healthy baseline. However, the progression of the MA phase remains poorly understood in traditional marker analysis. Analyzing EEG data from 74 individuals (24 AC, 23 MA, and 27 HC),
Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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Doxing via the Lens: Revealing Location-related Privacy Leakage on Multi-modal Large Reasoning Models
arXiv:2504.19373v5 Announce Type: replace-cross Abstract: Recent advances in multi-modal large reasoning models (MLRMs) have shown significant ability to interpret complex visual content. While these models enable impressive reasoning capabilities, they also introduce novel and underexplored privacy risks. In this paper, we identify a novel category of privacy leakage in MLRMs: Adversaries can infer sensitive geolocation information, such as a user's home address or neighborhood, from user-gene
Doxing via the Lens: Revealing Location-related Privacy Leakage on Multi-modal Large Reasoning Models
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cs.AI, q-bio.NC updates on arXiv.org
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MapReduce LoRA: Advancing the Pareto Front in Multi-Preference Optimization for Generative Models
arXiv:2511.20629v4 Announce Type: replace-cross Abstract: Reinforcement learning from human feedback (RLHF) with reward models has advanced alignment of generative models to human aesthetic and perceptual preferences. However, jointly optimizing multiple rewards often incurs an alignment tax, improving one dimension while degrading others. To address this, we introduce two complementary methods: MapReduce LoRA and Reward-aware Token Embedding (RaTE). MapReduce LoRA trains preference-specific Lo